ILV5_YEAST - dbPTM
ILV5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ILV5_YEAST
UniProt AC P06168
Protein Name Ketol-acid reductoisomerase, mitochondrial
Gene Name ILV5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 395
Subcellular Localization Mitochondrion.
Protein Description
Protein Sequence MLRTQAARLICNSRVITAKRTFALATRAAAYSRPAARFVKPMITTRGLKQINFGGTVETVYERADWPREKLLDYFKNDTFALIGYGSQGYGQGLNLRDNGLNVIIGVRKDGASWKAAIEDGWVPGKNLFTVEDAIKRGSYVMNLLSDAAQSETWPAIKPLLTKGKTLYFSHGFSPVFKDLTHVEPPKDLDVILVAPKGSGRTVRSLFKEGRGINSSYAVWNDVTGKAHEKAQALAVAIGSGYVYQTTFEREVNSDLYGERGCLMGGIHGMFLAQYDVLRENGHSPSEAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPIFKNALKPVFQDLYESTKNGTETKRSLEFNSQPDYREKLEKELDTIRNMEIWKVGKEVRKLRPENQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
70UbiquitinationRADWPREKLLDYFKN
HCCCCHHHHHHHHCC		56.4824961812
70SuccinylationRADWPREKLLDYFKN
HCCCCHHHHHHHHCC		56.4823954790
70AcetylationRADWPREKLLDYFKN
HCCCCHHHHHHHHCC		56.4824489116
76AcetylationEKLLDYFKNDTFALI
HHHHHHHCCCCEEEE		47.9225381059
76UbiquitinationEKLLDYFKNDTFALI
HHHHHHHCCCCEEEE		47.9217644757
79PhosphorylationLDYFKNDTFALIGYG
HHHHCCCCEEEEEEC		21.8728132839
85PhosphorylationDTFALIGYGSQGYGQ
CCEEEEEECCCCCCC		13.4528889911
1092-HydroxyisobutyrylationNVIIGVRKDGASWKA
EEEEEEECCCCCHHH		59.10-
109AcetylationNVIIGVRKDGASWKA
EEEEEEECCCCCHHH		59.1024489116
115SuccinylationRKDGASWKAAIEDGW
ECCCCCHHHHHHCCC		25.9923954790
115AcetylationRKDGASWKAAIEDGW
ECCCCCHHHHHHCCC		25.9924489116
115UbiquitinationRKDGASWKAAIEDGW
ECCCCCHHHHHHCCC		25.9917644757
126AcetylationEDGWVPGKNLFTVED
HCCCCCCCCCEEHHH		44.3924489116
126SuccinylationEDGWVPGKNLFTVED
HCCCCCCCCCEEHHH		44.3923954790
126UbiquitinationEDGWVPGKNLFTVED
HCCCCCCCCCEEHHH		44.3917644757
136SuccinylationFTVEDAIKRGSYVMN
EEHHHHHHHCCHHHH		53.0523954790
136UbiquitinationFTVEDAIKRGSYVMN
EEHHHHHHHCCHHHH		53.0524961812
136AcetylationFTVEDAIKRGSYVMN
EEHHHHHHHCCHHHH		53.0524489116
1362-HydroxyisobutyrylationFTVEDAIKRGSYVMN
EEHHHHHHHCCHHHH		53.05-
139PhosphorylationEDAIKRGSYVMNLLS
HHHHHHCCHHHHHHC		20.7021440633
151PhosphorylationLLSDAAQSETWPAIK
HHCHHHHCCCCCCHH		32.0630377154
153PhosphorylationSDAAQSETWPAIKPL
CHHHHCCCCCCHHHH		41.8325521595
158AcetylationSETWPAIKPLLTKGK
CCCCCCHHHHHCCCC		31.5524489116
158UbiquitinationSETWPAIKPLLTKGK
CCCCCCHHHHHCCCC		31.5517644757
163SuccinylationAIKPLLTKGKTLYFS
CHHHHHCCCCEEEEC		59.3823954790
163AcetylationAIKPLLTKGKTLYFS
CHHHHHCCCCEEEEC		59.3824489116
163UbiquitinationAIKPLLTKGKTLYFS
CHHHHHCCCCEEEEC		59.3817644757
165UbiquitinationKPLLTKGKTLYFSHG
HHHHCCCCEEEECCC		36.5917644757
1652-HydroxyisobutyrylationKPLLTKGKTLYFSHG
HHHHCCCCEEEECCC		36.59-
165AcetylationKPLLTKGKTLYFSHG
HHHHCCCCEEEECCC		36.5924489116
166PhosphorylationPLLTKGKTLYFSHGF
HHHCCCCEEEECCCC		35.0520377248
168PhosphorylationLTKGKTLYFSHGFSP
HCCCCEEEECCCCCC		14.3121440633
170PhosphorylationKGKTLYFSHGFSPVF
CCCEEEECCCCCCCH		14.7821440633
174PhosphorylationLYFSHGFSPVFKDLT
EEECCCCCCCHHCCC		25.4221440633
178UbiquitinationHGFSPVFKDLTHVEP
CCCCCCHHCCCCCCC		52.6517644757
178AcetylationHGFSPVFKDLTHVEP
CCCCCCHHCCCCCCC		52.6524489116
187UbiquitinationLTHVEPPKDLDVILV
CCCCCCCCCCEEEEE		80.0117644757
187AcetylationLTHVEPPKDLDVILV
CCCCCCCCCCEEEEE		80.0124489116
187SuccinylationLTHVEPPKDLDVILV
CCCCCCCCCCEEEEE		80.0123954790
197UbiquitinationDVILVAPKGSGRTVR
EEEEEEECCCCHHHH		56.8417644757
197SuccinylationDVILVAPKGSGRTVR
EEEEEEECCCCHHHH		56.8423954790
199PhosphorylationILVAPKGSGRTVRSL
EEEEECCCCHHHHHH		31.0928889911
208AcetylationRTVRSLFKEGRGINS
HHHHHHHHCCCCCCC		65.6324489116
208SuccinylationRTVRSLFKEGRGINS
HHHHHHHHCCCCCCC		65.6323954790
216PhosphorylationEGRGINSSYAVWNDV
CCCCCCCCEEECCCC		16.7827017623
217PhosphorylationGRGINSSYAVWNDVT
CCCCCCCEEECCCCC		12.6628889911
224PhosphorylationYAVWNDVTGKAHEKA
EEECCCCCCCHHHHH		35.5130377154
226AcetylationVWNDVTGKAHEKAQA
ECCCCCCCHHHHHHH		36.8924489116
226SuccinylationVWNDVTGKAHEKAQA
ECCCCCCCHHHHHHH		36.8923954790
2262-HydroxyisobutyrylationVWNDVTGKAHEKAQA
ECCCCCCCHHHHHHH		36.89-
284PhosphorylationVLRENGHSPSEAFNE
HHHHCCCCHHHHHHH		31.3622369663
286PhosphorylationRENGHSPSEAFNETV
HHCCCCHHHHHHHHH		44.5728132839
292PhosphorylationPSEAFNETVEEATQS
HHHHHHHHHHHHHHH		34.0322369663
297PhosphorylationNETVEEATQSLYPLI
HHHHHHHHHHHHHHH		23.2122369663
299PhosphorylationTVEEATQSLYPLIGK
HHHHHHHHHHHHHHH		26.0522369663
301PhosphorylationEEATQSLYPLIGKYG
HHHHHHHHHHHHHHC		10.9722369663
306AcetylationSLYPLIGKYGMDYMY
HHHHHHHHHCHHHHH		31.4725381059
307PhosphorylationLYPLIGKYGMDYMYD
HHHHHHHHCHHHHHH		16.6930377154
311PhosphorylationIGKYGMDYMYDACST
HHHHCHHHHHHHHCH		6.6730377154
313PhosphorylationKYGMDYMYDACSTTA
HHCHHHHHHHHCHHH		8.3130377154
317PhosphorylationDYMYDACSTTARRGA
HHHHHHHCHHHHCCC		30.4321440633
318PhosphorylationYMYDACSTTARRGAL
HHHHHHCHHHHCCCC		25.1028889911
319PhosphorylationMYDACSTTARRGALD
HHHHHCHHHHCCCCC		11.2430377154
332UbiquitinationLDWYPIFKNALKPVF
CCCHHHHHHHHHHHH		41.8717644757
332AcetylationLDWYPIFKNALKPVF
CCCHHHHHHHHHHHH		41.8724489116
336UbiquitinationPIFKNALKPVFQDLY
HHHHHHHHHHHHHHH		36.4017644757
336SuccinylationPIFKNALKPVFQDLY
HHHHHHHHHHHHHHH		36.4023954790
336AcetylationPIFKNALKPVFQDLY
HHHHHHHHHHHHHHH		36.4024489116
343PhosphorylationKPVFQDLYESTKNGT
HHHHHHHHHHCCCCC		19.0022369663
345PhosphorylationVFQDLYESTKNGTET
HHHHHHHHCCCCCCC		30.9922369663
346PhosphorylationFQDLYESTKNGTETK
HHHHHHHCCCCCCCH		19.3122369663
347AcetylationQDLYESTKNGTETKR
HHHHHHCCCCCCCHH		63.7624489116
347SuccinylationQDLYESTKNGTETKR
HHHHHHCCCCCCCHH		63.7623954790
347UbiquitinationQDLYESTKNGTETKR
HHHHHHCCCCCCCHH		63.7624961812
350PhosphorylationYESTKNGTETKRSLE
HHHCCCCCCCHHHHC		50.2928889911
352PhosphorylationSTKNGTETKRSLEFN
HCCCCCCCHHHHCCC		31.4321440633
353AcetylationTKNGTETKRSLEFNS
CCCCCCCHHHHCCCC		33.4825381059
355PhosphorylationNGTETKRSLEFNSQP
CCCCCHHHHCCCCCC		33.5321082442
360PhosphorylationKRSLEFNSQPDYREK
HHHHCCCCCCCHHHH		48.7022369663
367AcetylationSQPDYREKLEKELDT
CCCCHHHHHHHHHHH		53.6124489116
370AcetylationDYREKLEKELDTIRN
CHHHHHHHHHHHHHH		74.2024489116
3702-HydroxyisobutyrylationDYREKLEKELDTIRN
CHHHHHHHHHHHHHH		74.20-
374PhosphorylationKLEKELDTIRNMEIW
HHHHHHHHHHHHHHH		34.1721440633
382SuccinylationIRNMEIWKVGKEVRK
HHHHHHHHHHHHHHH		46.9323954790
382AcetylationIRNMEIWKVGKEVRK
HHHHHHHHHHHHHHH		46.9324489116
389AcetylationKVGKEVRKLRPENQ-
HHHHHHHHHCCCCC-		54.7625381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ILV5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ILV5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ILV5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OXA1_YEASTOXA1genetic
18826960
TIM17_YEASTTIM17genetic
18826960
BCA2_YEASTBAT2genetic
21798060
ILV6_YEASTILV6genetic
21798060
ILV5_YEASTILV5physical
22940862
PYR1_YEASTURA2physical
22940862
CHK1_YEASTCHK1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
ASK10_YEASTASK10genetic
27708008
OPI1_YEASTOPI1genetic
27708008
PMS1_YEASTPMS1genetic
27708008
OPY2_YEASTOPY2genetic
27708008
STU1_YEASTSTU1genetic
27708008
GNA1_YEASTGNA1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
ODPB_YEASTPDB1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
YCP7_YEASTYCR007Cgenetic
27708008
SNT1_YEASTSNT1genetic
27708008
ELO2_YEASTELO2genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
INO2_YEASTINO2genetic
27708008
PLP1_YEASTPLP1genetic
27708008
SWR1_YEASTSWR1genetic
27708008
RV167_YEASTRVS167genetic
27708008
FIT1_YEASTFIT1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
SGF73_YEASTSGF73genetic
27708008
MRM2_YEASTMRM2genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
MAL12_YEASTMAL12genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
SDS3_YEASTSDS3genetic
27708008
SNX4_YEASTSNX4genetic
27708008
MDM35_YEASTMDM35genetic
27708008
TCTP_YEASTTMA19genetic
27708008
SHE2_YEASTSHE2genetic
27708008
AVT3_YEASTAVT3genetic
27708008
PAM17_YEASTPAM17genetic
27708008
POM33_YEASTPOM33genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
HFA1_YEASTHFA1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
HRB1_YEASTHRB1genetic
27708008
YNB0_YEASTYNL010Wgenetic
27708008
ODP2_YEASTLAT1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
KC12_YEASTYCK2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
YOR31_YEASTYOR131Cgenetic
27708008
IES4_YEASTIES4genetic
27708008
PUS7_YEASTPUS7genetic
27708008
PALA_YEASTRIM20genetic
27708008
MUM3_YEASTMUM3genetic
27708008
HAP5_YEASTHAP5genetic
27708008
RAD1_YEASTRAD1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
MGR2_YEASTMGR2genetic
27708008
ISU1_YEASTISU1genetic
27708008
UME1_YEASTUME1genetic
27708008
POC4_YEASTPOC4genetic
27708008
AIM44_YEASTAIM44genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
THP3_YEASTTHP3genetic
27708008
CHMU_YEASTARO7genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ILV5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85; SER-317; THR-318 ANDSER-355, AND MASS SPECTROMETRY.

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