| UniProt ID | KC12_YEAST | |
|---|---|---|
| UniProt AC | P23292 | |
| Protein Name | Casein kinase I homolog 2 | |
| Gene Name | YCK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 546 | |
| Subcellular Localization |
Cell membrane Lipid-anchor . |
|
| Protein Description | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.. | |
| Protein Sequence | MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPDYEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNPPNEKSKRHRSKNHQYSSPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRYQLQPDDSHYDEEREASKLDPTSYEAYQQQTQQKYAQQQQKQMQQKSKQFANTGANGQTNKYPYNAQPTANDEQNAKNAAQDRNSNKSSKGFFSKLGCC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSQVQSPLT ------CCCCCCCCE | 38.77 | 22814378 | |
| 2 | Phosphorylation | ------MSQVQSPLT ------CCCCCCCCE | 38.77 | 22369663 | |
| 6 | Phosphorylation | --MSQVQSPLTATNS --CCCCCCCCEECCC | 24.03 | 22369663 | |
| 9 | Phosphorylation | SQVQSPLTATNSGLA CCCCCCCEECCCCCC | 34.52 | 22369663 | |
| 11 | Phosphorylation | VQSPLTATNSGLAVN CCCCCEECCCCCCCC | 25.36 | 22369663 | |
| 13 | Phosphorylation | SPLTATNSGLAVNNN CCCEECCCCCCCCCC | 30.72 | 22369663 | |
| 21 | Phosphorylation | GLAVNNNTMNSQMPN CCCCCCCCCCCCCCC | 21.61 | 22369663 | |
| 24 | Phosphorylation | VNNNTMNSQMPNRSN CCCCCCCCCCCCCCC | 19.62 | 22369663 | |
| 30 | Phosphorylation | NSQMPNRSNVRLVNG CCCCCCCCCEEEECC | 46.44 | 22369663 | |
| 38 | Phosphorylation | NVRLVNGTLPPSLHV CEEEECCCCCCCEEE | 30.78 | 23749301 | |
| 42 | Phosphorylation | VNGTLPPSLHVSSNL ECCCCCCCEEEECCC | 29.21 | 23749301 | |
| 46 | Phosphorylation | LPPSLHVSSNLNHNT CCCCEEEECCCCCCC | 11.63 | 23749301 | |
| 47 | Phosphorylation | PPSLHVSSNLNHNTG CCCEEEECCCCCCCC | 44.22 | 23749301 | |
| 53 | Phosphorylation | SSNLNHNTGNSSASY ECCCCCCCCCCCCCC | 30.14 | 23749301 | |
| 56 | Phosphorylation | LNHNTGNSSASYSGS CCCCCCCCCCCCCCC | 28.73 | 23749301 | |
| 57 | Phosphorylation | NHNTGNSSASYSGSQ CCCCCCCCCCCCCCC | 25.82 | 23749301 | |
| 59 | Phosphorylation | NTGNSSASYSGSQSR CCCCCCCCCCCCCCC | 23.06 | 23749301 | |
| 60 | Phosphorylation | TGNSSASYSGSQSRD CCCCCCCCCCCCCCC | 19.43 | 19779198 | |
| 61 | Phosphorylation | GNSSASYSGSQSRDD CCCCCCCCCCCCCCC | 29.49 | 23749301 | |
| 69 | Phosphorylation | GSQSRDDSTIVGLHY CCCCCCCCEEEEEEE | 25.07 | 22369663 | |
| 70 | Phosphorylation | SQSRDDSTIVGLHYK CCCCCCCEEEEEEEE | 27.03 | 22369663 | |
| 110 | Ubiquitination | AIKFEPRKTEAPQLK EEEECCCCCCCCCCH | 62.52 | 17644757 | |
| 117 | Ubiquitination | KTEAPQLKDEYRTYK CCCCCCCHHHHHHHH | 43.18 | 17644757 | |
| 243 | Phosphorylation | YREKKSLSGTARYMS CCHHCCCCCCCEEEH | 40.98 | 23749301 | |
| 286 | Ubiquitination | QLPWQGLKAPNNKQK CCCCCCCCCCCCHHH | 69.49 | 23749301 | |
| 371 | Phosphorylation | GGRGWDLSINKKPNL CCCCCCEECCCCCCC | 22.95 | 27017623 | |
| 401 | Phosphorylation | HRSKNHQYSSPDHHH HHHCCCCCCCCCHHH | 11.99 | 23749301 | |
| 402 | Phosphorylation | RSKNHQYSSPDHHHH HHCCCCCCCCCHHHH | 28.91 | 24961812 | |
| 403 | Phosphorylation | SKNHQYSSPDHHHHY HCCCCCCCCCHHHHH | 29.43 | 24961812 | |
| 410 | Phosphorylation | SPDHHHHYNQQQQQQ CCCHHHHHHHHHHHH | 15.43 | 23749301 | |
| 430 | Ubiquitination | AQAQAQAKVQQQQLQ HHHHHHHHHHHHHHH | 28.61 | 17644757 | |
| 448 | Phosphorylation | AQQQANRYQLQPDDS HHHHHHHHHCCCCCC | 17.24 | 26447709 | |
| 455 | Phosphorylation | YQLQPDDSHYDEERE HHCCCCCCCCCHHHH | 31.18 | 17330950 | |
| 457 | Phosphorylation | LQPDDSHYDEEREAS CCCCCCCCCHHHHHH | 29.06 | 17330950 | |
| 464 | Phosphorylation | YDEEREASKLDPTSY CCHHHHHHHCCCCHH | 29.06 | 28889911 | |
| 465 | Ubiquitination | DEEREASKLDPTSYE CHHHHHHHCCCCHHH | 65.05 | 23749301 | |
| 469 | Phosphorylation | EASKLDPTSYEAYQQ HHHHCCCCHHHHHHH | 43.54 | 28889911 | |
| 470 | Phosphorylation | ASKLDPTSYEAYQQQ HHHCCCCHHHHHHHH | 26.77 | 28889911 | |
| 471 | Phosphorylation | SKLDPTSYEAYQQQT HHCCCCHHHHHHHHH | 13.68 | 21440633 | |
| 474 | Phosphorylation | DPTSYEAYQQQTQQK CCCHHHHHHHHHHHH | 8.56 | 30377154 | |
| 481 | Ubiquitination | YQQQTQQKYAQQQQK HHHHHHHHHHHHHHH | 32.51 | 23749301 | |
| 488 | Ubiquitination | KYAQQQQKQMQQKSK HHHHHHHHHHHHHHH | 43.32 | 23749301 | |
| 493 | Ubiquitination | QQKQMQQKSKQFANT HHHHHHHHHHHHHHC | 42.61 | 22817900 | |
| 495 | Ubiquitination | KQMQQKSKQFANTGA HHHHHHHHHHHHCCC | 57.37 | 23749301 | |
| 508 | Ubiquitination | GANGQTNKYPYNAQP CCCCCCCCCCCCCCC | 51.49 | 23749301 | |
| 516 | Phosphorylation | YPYNAQPTANDEQNA CCCCCCCCCCHHHHH | 26.47 | 28889911 | |
| 524 | Ubiquitination | ANDEQNAKNAAQDRN CCHHHHHHHHHHHHH | 55.45 | 23749301 | |
| 532 | Phosphorylation | NAAQDRNSNKSSKGF HHHHHHHCCCCCCCC | 46.67 | 21440633 | |
| 535 | Phosphorylation | QDRNSNKSSKGFFSK HHHHCCCCCCCCHHH | 41.34 | 21440633 | |
| 536 | Phosphorylation | DRNSNKSSKGFFSKL HHHCCCCCCCCHHHC | 38.11 | 21440633 | |
| 541 | Phosphorylation | KSSKGFFSKLGCC-- CCCCCCHHHCCCC-- | 25.39 | 27214570 | |
| 545 | S-palmitoylation | GFFSKLGCC------ CCHHHCCCC------ | 3.45 | 15105419 | |
| 545 | S-palmitoylation | GFFSKLGCC------ CCHHHCCCC------ | 3.45 | - | |
| 546 | S-palmitoylation | FFSKLGCC------- CHHHCCCC------- | 6.24 | 15105419 | |
| 546 | S-palmitoylation | FFSKLGCC------- CHHHCCCC------- | 6.24 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KC12_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KC12_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KC12_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Palmitoylation | |
| Reference | PubMed |
| "Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 isnecessary and sufficient for plasma membrane targeting."; Babu P., Deschenes R.J., Robinson L.C.; J. Biol. Chem. 279:27138-27147(2004). Cited for: PALMITOYLATION AT CYS-545 AND CYS-546, AND MUTAGENESIS OF CYS-545 ANDCYS-546. | |
| "The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyltransferase."; Roth A.F., Feng Y., Chen L., Davis N.G.; J. Cell Biol. 159:23-28(2002). Cited for: PALMITOYLATION AT CYS-545 AND CYS-546. | |
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, AND MASSSPECTROMETRY. | |
