SOL2_YEAST - dbPTM
SOL2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOL2_YEAST
UniProt AC P37262
Protein Name 6-phosphogluconolactonase-like protein 2
Gene Name SOL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 315
Subcellular Localization Cytoplasm .
Protein Description May be involved in regulation of tRNA subcellular distribution..
Protein Sequence MTTTVPKIFAFHEFSDVAEAVADHVVHAQDGALAPKNERKHSVPNISMNALDMTREASCKSTASAAEGKSGSSGSGSGSSKPKKEKRFKIALSGGSLIEVLHEGLLKRDDVRWGDWDIYFADERLVPFSSNESNYGCAKRKILDLIDTAKYGTPKVYHIDESLIDDPQECADNYEKVLIRGFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNFQDNLREKLAWVVPVENAPSGPSTRISLTIPVICHSHRVTFVVEGATKAPIIKTIMERPEKGLPSSIVNEGAAGRVSWFVDDDALTDVLVTKKKYKFHQGLSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36AcetylationQDGALAPKNERKHSV
CCCCCCCCCCCCCCC		66.8724489116
42PhosphorylationPKNERKHSVPNISMN
CCCCCCCCCCCCCHH		42.1622369663
47PhosphorylationKHSVPNISMNALDMT
CCCCCCCCHHHHHHH		16.7822890988
54PhosphorylationSMNALDMTREASCKS
CHHHHHHHHHHHCCC		25.6522890988
58PhosphorylationLDMTREASCKSTASA
HHHHHHHHCCCCHHH		19.8222890988
61PhosphorylationTREASCKSTASAAEG
HHHHHCCCCHHHHCC		33.2719823750
62PhosphorylationREASCKSTASAAEGK
HHHHCCCCHHHHCCC		15.3219823750
64PhosphorylationASCKSTASAAEGKSG
HHCCCCHHHHCCCCC		28.2719823750
70PhosphorylationASAAEGKSGSSGSGS
HHHHCCCCCCCCCCC		55.5628889911
72PhosphorylationAAEGKSGSSGSGSGS
HHCCCCCCCCCCCCC		38.3228889911
73PhosphorylationAEGKSGSSGSGSGSS
HCCCCCCCCCCCCCC		40.2728889911
75PhosphorylationGKSGSSGSGSGSSKP
CCCCCCCCCCCCCCC		31.5628889911
77PhosphorylationSGSSGSGSGSSKPKK
CCCCCCCCCCCCCCC		36.8828889911
79PhosphorylationSSGSGSGSSKPKKEK
CCCCCCCCCCCCCCC		36.5628889911
80PhosphorylationSGSGSGSSKPKKEKR
CCCCCCCCCCCCCCC		57.4128889911
139UbiquitinationESNYGCAKRKILDLI
CCCCCHHHHHHHHHH		59.3024961812
148PhosphorylationKILDLIDTAKYGTPK
HHHHHHHHHCCCCCC		20.3224909858
273AcetylationTIMERPEKGLPSSIV
HHHHCCCCCCCHHHC		69.3124489116
308AcetylationLVTKKKYKFHQGLSI
EEECCCCCCCCCCCC		45.2924489116
314PhosphorylationYKFHQGLSI------
CCCCCCCCC------		32.8321440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SOL2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOL2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOL2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP14_YEASTUBP14physical
16554755
VHR2_YEASTVHR2physical
16554755
YL257_YEASTYLR257Wphysical
16554755
SAP30_YEASTSAP30genetic
19061648
FHL1_YEASTFHL1genetic
19061648
CHD1_YEASTCHD1genetic
19061648
KGUA_YEASTGUK1genetic
19269370
PLC1_YEASTPLC1genetic
19269370
FHL1_YEASTFHL1genetic
19269370
BMT2_YEASTBMT2genetic
20093466
RS6A_YEASTRPS6Bgenetic
20093466
RS6B_YEASTRPS6Bgenetic
20093466
ARF1_YEASTARF1genetic
20093466
YJ24_YEASTKCH1genetic
20093466
CTK3_YEASTCTK3genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
MKS1_YEASTMKS1genetic
20093466
CCZ1_YEASTCCZ1genetic
27708008
BMT2_YEASTBMT2genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
CG23_YEASTCLB3genetic
27708008
SGF73_YEASTSGF73genetic
27708008
HPM1_YEASTHPM1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
PUR91_YEASTADE16genetic
27708008
AIM34_YEASTAIM34genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
SOL1_YEASTSOL1genetic
27708008
PSH1_YEASTPSH1genetic
27708008
INO4_YEASTINO4genetic
27708008
ATG40_YEASTYOR152Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOL2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-61; THR-62 ANDSER-64, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-62 AND SER-64, AND MASSSPECTROMETRY.

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