CG23_YEAST - dbPTM
CG23_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CG23_YEAST
UniProt AC P24870
Protein Name G2/mitotic-specific cyclin-3
Gene Name CLB3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 427
Subcellular Localization
Protein Description Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis..
Protein Sequence MHHNSQSLSSGHIRSPEDENVAPIGNLKHRTGSLSHISSAHPRVALSDVTNIVATNSSNNSISKPKVAPIKERLDSAAIIEEERLDANSVAQRKEADHNDLLTDREQEEPVEDDGESEEDEEEDQEPLLLQHYASDTLVWEHAFRTYYRTTLDPNDDDVYDVVMVAELSNEIFEYMRKLEDLYKPNPYYMDKQPELRWSFRSTLIDWIVQVHEKFQLLPETLYLCINIIDRYLCKEVVPVNKFQLVGAASLFIAAKYEEINCPTIKDFVYMSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISKADDYEHDTRTLAKYLLESTIMDHRLVSAQPSWLAAGAYFLSKIILGQNQWSLAHVYYSNYTQEQILPLATIILENCRYASKRHNAIWRKYSSRRYLHSSQIVAKWIALAEHRVERSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MHHNSQSLSSGH
---CCCCCCCCCCCC		19.4530377154
7Phosphorylation-MHHNSQSLSSGHIR
-CCCCCCCCCCCCCC		30.0028889911
10PhosphorylationHNSQSLSSGHIRSPE
CCCCCCCCCCCCCCC		39.4224961812
15PhosphorylationLSSGHIRSPEDENVA
CCCCCCCCCCCCCCC		31.8528889911
31PhosphorylationIGNLKHRTGSLSHIS
CCCCCCCCCCHHHHH		30.7328889911
33PhosphorylationNLKHRTGSLSHISSA
CCCCCCCCHHHHHCC		26.5321082442
50PhosphorylationRVALSDVTNIVATNS
CEEHHHCCEEEEECC		24.9930377154
57PhosphorylationTNIVATNSSNNSISK
CEEEEECCCCCCCCC		30.0428889911
58PhosphorylationNIVATNSSNNSISKP
EEEEECCCCCCCCCC		41.9428889911
61PhosphorylationATNSSNNSISKPKVA
EECCCCCCCCCCCCC		32.2721082442
63PhosphorylationNSSNNSISKPKVAPI
CCCCCCCCCCCCCCH		42.6021082442
89PhosphorylationEERLDANSVAQRKEA
HHHCCHHHHHHHHHC		22.1328889911
103PhosphorylationADHNDLLTDREQEEP
CCCCCCCCHHHCCCC		40.0625704821
323AcetylationHDTRTLAKYLLESTI
CCHHHHHHHHHHHCC		39.2724489116
352UbiquitinationAGAYFLSKIILGQNQ
HHHHHHHHHHHCCCC		35.5917644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCDC20P26309
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseCDH1P53197
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CG23_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CG23_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CKS1_YEASTCKS1physical
10688190
CDK1_YEASTCDC28physical
10206189
CDH1_YEASTCDH1physical
11566880
CDK1_YEASTCDC28physical
7973730
CDK1_YEASTCDC28physical
15200949
CKS1_YEASTCKS1physical
15200949
SIC1_YEASTSIC1physical
15200949
CDC53_YEASTCDC53physical
15200949
CDC4_YEASTCDC4physical
15200949
CDH1_YEASTCDH1physical
15200949
CDC25_YEASTCDC25physical
15200949
ACE2_YEASTACE2physical
15200949
DBF2_YEASTDBF2physical
15200949
MOB1_YEASTMOB1physical
15200949
CBK1_YEASTCBK1physical
15200949
BIK1_YEASTBIK1physical
15200949
MDS3_YEASTMDS3physical
15200949
ACM1_YEASTACM1physical
15200949
CKS1_YEASTCKS1physical
16554755
CDK1_YEASTCDC28physical
16554755
SIC1_YEASTSIC1physical
16554755
RV161_YEASTRVS161genetic
17314980
TAF5_YEASTTAF5genetic
17314980
SPC29_YEASTSPC29physical
11283351
PFD2_YEASTGIM4genetic
19269370
2ABA_YEASTCDC55genetic
19269370
BUB1_YEASTBUB1genetic
19269370
PLMT_YEASTOPI3genetic
19269370
CG22_YEASTCLB2genetic
19269370
BUB3_YEASTBUB3genetic
19581447
MAD2_YEASTMAD2genetic
19581447
ACE2_YEASTACE2physical
20489023
ACM1_YEASTACM1physical
20489023
ADR1_YEASTADR1physical
20489023
BOB1_YEASTBOI1physical
20489023
CDC14_YEASTCDC14physical
20489023
CDC25_YEASTCDC25physical
20489023
CDK1_YEASTCDC28physical
20489023
CKS1_YEASTCKS1physical
20489023
DBF2_YEASTDBF2physical
20489023
GIN4_YEASTGIN4physical
20489023
GLE2_YEASTGLE2physical
20489023
GLN3_YEASTGLN3physical
20489023
MDS3_YEASTMDS3physical
20489023
MPIP_YEASTMIH1physical
20489023
MKS1_YEASTMKS1physical
20489023
NDD1_YEASTNDD1physical
20489023
NET1_YEASTNET1physical
20489023
NU100_YEASTNUP100physical
20489023
NU116_YEASTNUP116physical
20489023
NU159_YEASTNUP159physical
20489023
RPC2_YEASTRET1physical
20489023
RPA2_YEASTRPA135physical
20489023
RPA1_YEASTRPA190physical
20489023
RPAB5_YEASTRPB10physical
20489023
RPAC1_YEASTRPC40physical
20489023
SIC1_YEASTSIC1physical
20489023
TGL5_YEASTTGL5physical
20489023
TOF2_YEASTTOF2physical
20489023
YHJ3_YEASTYHR033Wphysical
20489023
CG22_YEASTCLB2genetic
20581451
CG24_YEASTCLB4genetic
20581451
CG24_YEASTCLB4genetic
20598539
ASE1_YEASTASE1genetic
21558801
PHO2_YEASTPHO2genetic
21127252
PDP2_YEASTPTC6genetic
21127252
CDK1_YEASTCDC28physical
21658602
CG21_YEASTCLB1genetic
21784165
SIC1_YEASTSIC1physical
21963604
CDK1_YEASTCDC28physical
23751495
CDK1_YEASTCDC28physical
10871278
SIC1_YEASTSIC1genetic
27794027
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CG23_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory