ADR1_YEAST - dbPTM
ADR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADR1_YEAST
UniProt AC P07248
Protein Name Regulatory protein ADR1
Gene Name ADR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1323
Subcellular Localization Nucleus.
Protein Description Required for transcriptional activation of glucose-repressible alcohol dehydrogenase (ADH2)..
Protein Sequence MANVEKPNDCSGFPVVDLNSCFSNGFNNEKQEIEMETDDSPILLMSSSASRENSNTFSVIQRTPDGKIITTNNNMNSKINKQLDKLPENLRLNGRTPSGKLRSFVCEVCTRAFARQEHLKRHYRSHTNEKPYPCGLCNRCFTRRDLLIRHAQKIHSGNLGETISHTKKVSRTITKARKNSASSVKFQTPTYGTPDNGNFLNRTTANTRRKASPEANVKRKYLKKLTRRASFSAQSASSYALPDQSSLEQHPKDRVKFSTPELVPLDLKNPELDSSFDLNMNLDLNLNLDSNFNIALNRSDSSGSTMNLDYKLPESANNYTYSSGSPTRAYVGANTNSKNASFNDADLLSSSYWIKAYNDHLFSVSESDETSPMNSELNDTKLIVPDFKSTIHHLKDSRSSSWTVAIDNNSNNNKVSDNQPDFVDFQELLDNDTLGNDLLETTAVLKEFELLHDDSVSATATSNEIDLSHLNLSNSPISPHKLIYKNKEGTNDDMLISFGLDHPSNREDDLDKLCNMTRDVQAIFSQYLKGEESKRSLEDFLSTSNRKEKPDSGNYTFYGLDCLTLSKISRALPASTVNNNQPSHSIESKLFNEPMRNMCIKVLRYYEKFSHDSSESVMDSNPNLLSKELLMPAVSELNEYLDLFKNNFLPHFPIIHPSLLDLDLDSLQRYTNEDGYDDAENAQLFDRLSQGTDKEYDYEHYQILSISKIVCLPLFMATFGSLHKFGYKSQTIELYEMSRRILHSFLETKRRCRSTTVNDSYQNIWLMQSLILSFMFALVADYLEKIDSSLMKRQLSALCSTIRSNCLPTISANSEKSINNNNEPLTFGSPLQYIIFESKIRCTLMAYDFCQFLKCFFHIKFDLSIKEKDVETIYIPDNESKWASESIICNGHVVQKQNFYDFRNFYYSFTYGHLHSIPEFLGSSMIYYEYDLRKGTKSHVFLDRIDTKRLERSLDTSSYGNDNMAATNKNIAILIDDTIILKNNLMSMRFIKQIDRSFTEKVRKGQIAKIYDSFLNSVRLNFLKNYSVEVLCEFLVALNFSIRNISSLYVEEESDCSQRMNSPELPRIHLNNQALSVFNLQGYYYCFILIIKFLLDFEATPNFKLLRIFIELRSLANSILLPTLSRLYPQEFSGFPDVVFTQQFINKDNGMLVPGLSANEHHNGASAAVKTKLAKKINVEGLAMFINEILVNSFNDTSFLNMEDPIRNEFSFDNGDRAVTDLPRSAHFLSDTGLEGINFSGLNDSHQTVSTLNLLRYGENHSSKHKNGGKGQGFAEKYQLSLKYVTIAKLFFTNVKENYIHCHMLDKMASDFHTLENHLKGNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationIEMETDDSPILLMSS
EEECCCCCCEEEEEC		19.3629734811
54PhosphorylationSSASRENSNTFSVIQ
CCCCCCCCCCEEEEE		32.2827214570
56PhosphorylationASRENSNTFSVIQRT
CCCCCCCCEEEEEEC		19.6719779198
58PhosphorylationRENSNTFSVIQRTPD
CCCCCCEEEEEECCC		19.1030377154
63PhosphorylationTFSVIQRTPDGKIIT
CEEEEEECCCCCEEE		14.8923749301
98PhosphorylationRLNGRTPSGKLRSFV
HHCCCCCCCHHHHHH		48.2018791642
127PhosphorylationKRHYRSHTNEKPYPC
HHHHHHCCCCCCCCC		46.4428889911
180PhosphorylationITKARKNSASSVKFQ
HHHHHHCCCCCCEEE		32.3425752575
182PhosphorylationKARKNSASSVKFQTP
HHHHCCCCCCEEECC		35.1728889911
183PhosphorylationARKNSASSVKFQTPT
HHHCCCCCCEEECCC		29.1028889911
188PhosphorylationASSVKFQTPTYGTPD
CCCCEEECCCCCCCC		22.2622369663
190PhosphorylationSVKFQTPTYGTPDNG
CCEEECCCCCCCCCC		37.6622369663
191PhosphorylationVKFQTPTYGTPDNGN
CEEECCCCCCCCCCC		21.8722369663
193PhosphorylationFQTPTYGTPDNGNFL
EECCCCCCCCCCCCC		19.6322369663
212PhosphorylationANTRRKASPEANVKR
CCCCCCCCCCHHHHH		26.7225521595
221PhosphorylationEANVKRKYLKKLTRR
CHHHHHHHHHHHHHH		27.9928889911
226PhosphorylationRKYLKKLTRRASFSA
HHHHHHHHHHHCCCC		27.3021440633
230PhosphorylationKKLTRRASFSAQSAS
HHHHHHHCCCCCCCC		20.2317330950
232PhosphorylationLTRRASFSAQSASSY
HHHHHCCCCCCCCHH		23.9322890988
235PhosphorylationRASFSAQSASSYALP
HHCCCCCCCCHHCCC		29.8122890988
237PhosphorylationSFSAQSASSYALPDQ
CCCCCCCCHHCCCCH		29.1822890988
238PhosphorylationFSAQSASSYALPDQS
CCCCCCCHHCCCCHH		17.7222890988
239PhosphorylationSAQSASSYALPDQSS
CCCCCCHHCCCCHHH		15.0622890988
245PhosphorylationSYALPDQSSLEQHPK
HHCCCCHHHHHCCCC		44.2522890988
258PhosphorylationPKDRVKFSTPELVPL
CCCCCCCCCCCCEEC		37.0222890988
259PhosphorylationKDRVKFSTPELVPLD
CCCCCCCCCCCEECC		24.7422369663
299PhosphorylationFNIALNRSDSSGSTM
EEEEECCCCCCCCCC		40.5522369663
301PhosphorylationIALNRSDSSGSTMNL
EEECCCCCCCCCCCC		37.5322369663
302PhosphorylationALNRSDSSGSTMNLD
EECCCCCCCCCCCCE		41.5822369663
304PhosphorylationNRSDSSGSTMNLDYK
CCCCCCCCCCCCEEE		26.8222369663
305PhosphorylationRSDSSGSTMNLDYKL
CCCCCCCCCCCEEEC		17.3822369663
310PhosphorylationGSTMNLDYKLPESAN
CCCCCCEEECCCCCC		20.0022369663
315PhosphorylationLDYKLPESANNYTYS
CEEECCCCCCCCCCC		34.0623749301
319PhosphorylationLPESANNYTYSSGSP
CCCCCCCCCCCCCCC		13.5823749301
320PhosphorylationPESANNYTYSSGSPT
CCCCCCCCCCCCCCC		21.0322369663
321PhosphorylationESANNYTYSSGSPTR
CCCCCCCCCCCCCCE		7.1722369663
322PhosphorylationSANNYTYSSGSPTRA
CCCCCCCCCCCCCEE		22.0322369663
323PhosphorylationANNYTYSSGSPTRAY
CCCCCCCCCCCCEEE		32.6422369663
325PhosphorylationNYTYSSGSPTRAYVG
CCCCCCCCCCEEEEC		25.6622369663
327PhosphorylationTYSSGSPTRAYVGAN
CCCCCCCCEEEECCC		29.6320377248
341PhosphorylationNTNSKNASFNDADLL
CCCCCCCCCCCHHHH		33.6930377154
351PhosphorylationDADLLSSSYWIKAYN
CHHHHCHHHHHHHHC		22.5528889911
363PhosphorylationAYNDHLFSVSESDET
HHCCCEEECCCCCCC		30.9719779198
365PhosphorylationNDHLFSVSESDETSP
CCCEEECCCCCCCCC		30.1321440633
367PhosphorylationHLFSVSESDETSPMN
CEEECCCCCCCCCCC		32.9921440633
370PhosphorylationSVSESDETSPMNSEL
ECCCCCCCCCCCCCC		43.0222369663
371PhosphorylationVSESDETSPMNSELN
CCCCCCCCCCCCCCC		21.8022369663
375PhosphorylationDETSPMNSELNDTKL
CCCCCCCCCCCCCEE		36.8921440633
380PhosphorylationMNSELNDTKLIVPDF
CCCCCCCCEEEECCH		27.0319779198
389PhosphorylationLIVPDFKSTIHHLKD
EEECCHHHHHHHHCC		32.3724961812
390PhosphorylationIVPDFKSTIHHLKDS
EECCHHHHHHHHCCC		25.5624961812
397PhosphorylationTIHHLKDSRSSSWTV
HHHHHCCCCCCCEEE		32.2619823750
399PhosphorylationHHLKDSRSSSWTVAI
HHHCCCCCCCEEEEE		32.4522369663
400PhosphorylationHLKDSRSSSWTVAID
HHCCCCCCCEEEEEE		28.8722369663
401PhosphorylationLKDSRSSSWTVAIDN
HCCCCCCCEEEEEEC		28.1922369663
403PhosphorylationDSRSSSWTVAIDNNS
CCCCCCEEEEEECCC		11.2922369663
410PhosphorylationTVAIDNNSNNNKVSD
EEEEECCCCCCCCCC		47.3819823750
457PhosphorylationLLHDDSVSATATSNE
HHCCCCCCCEEECCC		24.6919779198
459PhosphorylationHDDSVSATATSNEID
CCCCCCCEEECCCEE		23.9821440633
461PhosphorylationDSVSATATSNEIDLS
CCCCCEEECCCEEHH		27.9419779198
462PhosphorylationSVSATATSNEIDLSH
CCCCEEECCCEEHHH		29.9621440633
468PhosphorylationTSNEIDLSHLNLSNS
ECCCEEHHHHCCCCC		23.3721440633
473PhosphorylationDLSHLNLSNSPISPH
EHHHHCCCCCCCCCC		33.9021551504
475PhosphorylationSHLNLSNSPISPHKL
HHHCCCCCCCCCCCE		21.8927214570
478PhosphorylationNLSNSPISPHKLIYK
CCCCCCCCCCCEEEE		25.0821551504
490PhosphorylationIYKNKEGTNDDMLIS
EEECCCCCCCCEEEE		36.2424961812
533PhosphorylationQYLKGEESKRSLEDF
HHHCCHHHHHHHHHH		29.1230377154
536PhosphorylationKGEESKRSLEDFLST
CCHHHHHHHHHHHHC		39.5930377154
542PhosphorylationRSLEDFLSTSNRKEK
HHHHHHHHCCCCCCC		29.7730377154
610PhosphorylationLRYYEKFSHDSSESV
HHHHHHHCCCCCCHH		37.1427017623
613PhosphorylationYEKFSHDSSESVMDS
HHHHCCCCCCHHHCC		30.4927214570
614PhosphorylationEKFSHDSSESVMDSN
HHHCCCCCCHHHCCC		39.6927017623
620PhosphorylationSSESVMDSNPNLLSK
CCCHHHCCCCCCCCH		35.7723749301
635PhosphorylationELLMPAVSELNEYLD
HHHHHHHHHHHHHHH		38.1728889911
698PhosphorylationGTDKEYDYEHYQILS
CCCCCCCHHHHHHHH		12.0528889911
789PhosphorylationYLEKIDSSLMKRQLS
HHHHHCHHHHHHHHH		28.8330377154
1062PhosphorylationDCSQRMNSPELPRIH
HHHHHCCCCCCCCEE		15.4827214570
1225PhosphorylationAVTDLPRSAHFLSDT
CCCCCCCCCCCCCCC		24.9322369663
1230PhosphorylationPRSAHFLSDTGLEGI
CCCCCCCCCCCCCCC		31.9822369663
1232PhosphorylationSAHFLSDTGLEGINF
CCCCCCCCCCCCCCC		40.0522369663
1240PhosphorylationGLEGINFSGLNDSHQ
CCCCCCCCCCCCCCC		37.5722369663
1245PhosphorylationNFSGLNDSHQTVSTL
CCCCCCCCCCHHHHH		19.2022369663
1248PhosphorylationGLNDSHQTVSTLNLL
CCCCCCCHHHHHHHH		15.8222369663
1250PhosphorylationNDSHQTVSTLNLLRY
CCCCCHHHHHHHHHC		30.4822369663
1251PhosphorylationDSHQTVSTLNLLRYG
CCCCHHHHHHHHHCC		18.4822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
230SPhosphorylationKinaseAMPK-FAMILY-GPS
230SPhosphorylationKinasePKA-FAMILY-GPS
230SPhosphorylationKinasePKA-Uniprot
230SPhosphorylationKinaseAMPK_GROUP-PhosphoELM
230SPhosphorylationKinasePKA_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
230SPhosphorylation

17287358
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADA2_YEASTADA2physical
8943299
GCN5_YEASTGCN5physical
8943299
TF2B_YEASTSUA7physical
8943299
SNF1_YEASTSNF1physical
12167649
TBP_YEASTSPT15physical
9742103
TAF1_YEASTTAF1physical
9742103
TAF6_YEASTTAF6physical
9742103
TAF10_YEASTTAF10physical
9742103
CAT8_YEASTCAT8physical
15743812
PIP2_YEASTPIP2genetic
12748191
SNF1_YEASTSNF1genetic
6392016
SNF1_YEASTSNF1genetic
3540604
REG1_YEASTREG1genetic
8321238
HDA1_YEASTHDA1genetic
17974563
RPD3_YEASTRPD3genetic
17974563
REG1_YEASTREG1genetic
17974563
MNN10_YEASTMNN10genetic
19269370
GIN4_YEASTGIN4genetic
19269370
BMH1_YEASTBMH1physical
20489023
NET1_YEASTNET1physical
20489023
SPT20_YEASTSPT20physical
20489023
SPT7_YEASTSPT7physical
20489023
SPT8_YEASTSPT8physical
20489023
TAF6_YEASTTAF6physical
20489023
BMH1_YEASTBMH1physical
20855531
SWI5_YEASTSWI5genetic
20831804
RFX1_YEASTRFX1genetic
20831804
ECM22_YEASTECM22genetic
20831804
DAL81_YEASTDAL81genetic
20831804
FKH2_YEASTFKH2genetic
20831804
CRZ1_YEASTCRZ1genetic
20959818
MET32_YEASTMET32genetic
20959818
RPB3_YEASTRPB3genetic
20959818
AATC_YEASTAAT2genetic
20959818
SDS3_YEASTSDS3genetic
20959818
NPR2_YEASTNPR2genetic
20959818
VMS1_YEASTVMS1genetic
20959818
PP2C1_YEASTPTC1genetic
21127252
FUS3_YEASTFUS3genetic
21127252
REI1_YEASTREI1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
IPMK_YEASTARG82genetic
21127252
CAT8_YEASTCAT8genetic
22306658
SEC22_YEASTSEC22genetic
23891562
YPT6_YEASTYPT6genetic
23891562
CAT8_YEASTCAT8genetic
24200791
CLP1_YEASTCLP1genetic
27708008
RDR1_YEASTRDR1genetic
27708008
ACT_YEASTACT1genetic
27708008
SWC4_YEASTSWC4genetic
27708008
TEL2_YEASTTEL2genetic
27708008
STS1_YEASTSTS1genetic
27708008
RRN7_YEASTRRN7genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NOC3_YEASTNOC3genetic
27708008
SSL1_YEASTSSL1genetic
27708008
AFG2_YEASTAFG2genetic
27708008
TAF11_YEASTTAF11genetic
27708008
HAS1_YEASTHAS1genetic
27708008
NOG2_YEASTNOG2genetic
27708008
IF6_YEASTTIF6genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
PRY2_YEASTPRY2genetic
27708008
YL413_YEASTINA1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
SUCA_YEASTLSC1genetic
27708008
TAF1_YEASTTAF1physical
28994223
SWC5_YEASTSWC5genetic
29674565
SLX5_YEASTSLX5genetic
29674565
AK_YEASTHOM3genetic
29674565
CEM1_YEASTCEM1genetic
29674565
TCPE_YEASTCCT5genetic
29674565
RL43A_YEASTRPL43Bgenetic
29674565
RL43B_YEASTRPL43Bgenetic
29674565
YJ9I_YEASTYJR141Wgenetic
29674565
COG8_YEASTCOG8genetic
29674565
CAP_YEASTSRV2genetic
29674565
LSM7_YEASTLSM7genetic
29674565
SGT2_YEASTSGT2genetic
29674565
VAM3_YEASTVAM3genetic
29674565
ATPN_YEASTATP20genetic
29674565
BRR1_YEASTBRR1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ADR1c mutations enhance the ability of ADR1 to activate transcriptionby a mechanism that is independent of effects on cyclic AMP-dependentprotein kinase phosphorylation of Ser-230.";
Denis C.L., Fontaine S.C., Chase D., Kemp B.E., Bemis L.T.;
Mol. Cell. Biol. 12:1507-1514(1992).
Cited for: MUTAGENESIS, AND PHOSPHORYLATION AT SER-230.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-193; SER-212; SER-230;THR-259; SER-301; SER-322; SER-323; THR-327; SER-400; SER-401;SER-475; THR-1248 AND SER-1250, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-259, AND MASSSPECTROMETRY.

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