| UniProt ID | SWC4_YEAST | |
|---|---|---|
| UniProt AC | P53201 | |
| Protein Name | SWR1-complex protein 4 | |
| Gene Name | SWC4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 476 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.. | |
| Protein Sequence | MSSSDIFDVLNIKQKSRSPTNGQVSVPSSSAANRPKPQVTGMQRELFNLLGENQPPVVIKSGNNFKEKMLSTSKPSPWSFVEFKANNSVTLRHWVKGSKELIGDTPKESPYSKFNQHLSIPSFTKEEYEAFMNENEGTQKSVESEKNHNENFTNEKKDESKNSWSFEEIEYLFNLCKKYDLRWFLIFDRYSYNNSRTLEDLKEKFYYTCRNYFKASDPSNPLLSSLNFSAEKEIERKKYLQRLLSRSAAEIAEEEALVVESKKFEMAAKRTLAERESLLRLLDSPHSDQTITQYLTSQGMSQLYNALLADKTRKRKHDLNIPENPWMKQQQQFAQHRQLQQLNVKKSEVKENLSPKKTKRQRQEMQTALKRKSESAYAEQLLKDFNSDERKALGVITHGEKLSPGVYLRSTKLSTFKPALQNKILAILQELSLPSRPVMPSFDVMERQEELLKKINTLIDLKKHVDKYEAGMSITK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSSDIFDV ------CCHHHHHHH | 38.25 | 30377154 | |
| 2 | Acetylation | ------MSSSDIFDV ------CCHHHHHHH | 38.25 | 22814378 | |
| 3 | Phosphorylation | -----MSSSDIFDVL -----CCHHHHHHHH | 30.63 | 30377154 | |
| 4 | Phosphorylation | ----MSSSDIFDVLN ----CCHHHHHHHHC | 27.67 | 30377154 | |
| 16 | Phosphorylation | VLNIKQKSRSPTNGQ HHCCCCCCCCCCCCC | 35.18 | 28889911 | |
| 18 | Phosphorylation | NIKQKSRSPTNGQVS CCCCCCCCCCCCCCC | 43.07 | 21440633 | |
| 20 | Phosphorylation | KQKSRSPTNGQVSVP CCCCCCCCCCCCCCC | 53.91 | 24961812 | |
| 25 | Phosphorylation | SPTNGQVSVPSSSAA CCCCCCCCCCCHHHC | 22.03 | 30377154 | |
| 99 | Acetylation | RHWVKGSKELIGDTP EHHHCCCHHHCCCCC | 66.27 | 25381059 | |
| 113 | Acetylation | PKESPYSKFNQHLSI CCCCCCHHHHHCCCC | 42.35 | 22865919 | |
| 146 | Acetylation | QKSVESEKNHNENFT HHHHHHHHHCCCCCC | 73.17 | 22865919 | |
| 345 | Acetylation | QLQQLNVKKSEVKEN HHHHHCCCHHHHHHH | 49.89 | 23572591 | |
| 346 | Acetylation | LQQLNVKKSEVKENL HHHHCCCHHHHHHHC | 47.79 | 23572591 | |
| 350 | Acetylation | NVKKSEVKENLSPKK CCCHHHHHHHCCCHH | 36.51 | 23572591 | |
| 354 | Phosphorylation | SEVKENLSPKKTKRQ HHHHHHCCCHHHHHH | 46.37 | 23749301 | |
| 370 | Acetylation | QEMQTALKRKSESAY HHHHHHHHHHCHHHH | 56.14 | 25381059 | |
| 373 | Phosphorylation | QTALKRKSESAYAEQ HHHHHHHCHHHHHHH | 40.59 | 26447709 | |
| 375 | Phosphorylation | ALKRKSESAYAEQLL HHHHHCHHHHHHHHH | 33.40 | 26447709 | |
| 377 | Phosphorylation | KRKSESAYAEQLLKD HHHCHHHHHHHHHHH | 21.68 | 26447709 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SWC4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SWC4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SWC4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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