dbPTM

PRP19_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRP19_YEAST
UniProt AC	P32523
Protein Name	Pre-mRNA-processing factor 19 {ECO:0000305}
Gene Name	PRP19
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	503
Subcellular Localization	Nucleus .
Protein Description	Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair..
Protein Sequence	MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	RPVLSPKSRTIFEKS CCCCCCCCCCHHHHH	37.73	21440633
21	Phosphorylation	VLSPKSRTIFEKSLL CCCCCCCCHHHHHHH	36.79	21440633
31	Phosphorylation	EKSLLEQYVKDTGND HHHHHHHHHHHHCCC	10.49	21440633
110	Phosphorylation	DSLTKKLSTVMYERD HHHHHHHHHHHHHHH	28.03	19779198
140	Phosphorylation	DSKDLPKSSQQAVAI CCCCCCHHHHHHHHH	31.29	22369663
141	Phosphorylation	SKDLPKSSQQAVAIT CCCCCHHHHHHHHHC	32.22	22369663
148	Phosphorylation	SQQAVAITREEFLQG HHHHHHHCHHHHHHH	23.45	22369663
159	Phosphorylation	FLQGLLQSSRDFVAR HHHHHHHHCCHHHHC	27.58	22369663
160	Phosphorylation	LQGLLQSSRDFVARG HHHHHHHCCHHHHCC	23.94	22369663
173	Acetylation	RGKLKAPKWPILKNL CCCCCCCCCHHHHCH	71.15	24489116
329	Phosphorylation	YIVHSAKSDVEYSSG EEEEECCCCCEECCC	46.75	30377154
333	Phosphorylation	SAKSDVEYSSGVLHK ECCCCCEECCCCCCC	14.16	30377154
334	Phosphorylation	AKSDVEYSSGVLHKD CCCCCEECCCCCCCC	13.70	30377154
335	Phosphorylation	KSDVEYSSGVLHKDS CCCCEECCCCCCCCE	31.83	30377154
348	Phosphorylation	DSLLLALYSPDGILD CEEEEEEECCCCEEE	16.73	30377154
349	Phosphorylation	SLLLALYSPDGILDV EEEEEEECCCCEEEE	19.84	30377154
404	Acetylation	VVCFDLRKDVGTLAY EEEEEECCCCEECCC	65.15	24489116
433	Acetylation	YDIDDSGKNMIAYSN EEECCCCCEEEEEEC	47.50	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
141	S	Phosphorylation	Kinase	ATM/ATR	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRP19_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRP19_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEF1_YEAST	CEF1	physical	14759368
CLF1_YEAST	CLF1	physical	14759368
PRP19_YEAST	PRP19	physical	14759368
SN309_YEAST	SNT309	physical	11805837
CEF1_YEAST	CEF1	physical	11805837
CLF1_YEAST	CLF1	physical	11805837
CEF1_YEAST	CEF1	physical	11884590
CWC2_YEAST	CWC2	physical	11884590
BRR2_YEAST	BRR2	physical	11884590
PRP17_YEAST	CDC40	physical	11884590
CLF1_YEAST	CLF1	physical	11884590
CUS1_YEAST	CUS1	physical	11884590
BUD31_YEAST	BUD31	physical	11884590
CWC15_YEAST	CWC15	physical	11884590
CWC16_YEAST	YJU2	physical	11884590
CWC23_YEAST	CWC23	physical	11884590
CWC24_YEAST	CWC24	physical	11884590
CWC25_YEAST	CWC25	physical	11884590
CWC26_YEAST	BUD13	physical	11884590
SLT11_YEAST	ECM2	physical	11884590
SF3B1_YEAST	HSH155	physical	11884590
IST3_YEAST	IST3	physical	11884590
RU2A_YEAST	LEA1	physical	11884590
MSL1_YEAST	MSL1	physical	11884590
NTC20_YEAST	NTC20	physical	11884590
ISY1_YEAST	ISY1	physical	11884590
PRP11_YEAST	PRP11	physical	11884590
PRP21_YEAST	PRP21	physical	11884590
PRP22_YEAST	PRP22	physical	11884590
PRP45_YEAST	PRP45	physical	11884590
PRP46_YEAST	PRP46	physical	11884590
PRP8_YEAST	PRP8	physical	11884590
PRP9_YEAST	PRP9	physical	11884590
RSE1_YEAST	RSE1	physical	11884590
SLU7_YEAST	SLU7	physical	11884590
RSMB_YEAST	SMB1	physical	11884590
SMD1_YEAST	SMD1	physical	11884590
SMD2_YEAST	SMD2	physical	11884590
SMD3_YEAST	SMD3	physical	11884590
RUXF_YEAST	SMX3	physical	11884590
SN309_YEAST	SNT309	physical	11884590
SN114_YEAST	SNU114	physical	11884590
SPP2_YEAST	SPP2	physical	11884590
SYF1_YEAST	SYF1	physical	11884590
SYF2_YEAST	SYF2	physical	11884590
ISY1_YEAST	ISY1	physical	11842115
SN309_YEAST	SNT309	physical	11842115
SN309_YEAST	SNT309	physical	11018040
SYF1_YEAST	SYF1	physical	11842115
CLF1_YEAST	CLF1	physical	11842115
NTC20_YEAST	NTC20	physical	11842115
NTC20_YEAST	NTC20	physical	10318896
ISY1_YEAST	ISY1	physical	10318896
SN309_YEAST	SNT309	physical	10318896
SN309_YEAST	SNT309	physical	9528791
PRP19_YEAST	PRP19	physical	12434004
SN309_YEAST	SNT309	physical	12434004
SYF2_YEAST	SYF2	physical	11842115
CEF1_YEAST	CEF1	physical	10092627
PRP19_YEAST	PRP19	physical	10092627
PRP19_YEAST	PRP19	physical	11967834
PRP19_YEAST	PRP19	physical	15601865
PRP39_YEAST	PRP39	physical	11804584
SNU71_YEAST	SNU71	physical	11804584
PRP40_YEAST	PRP40	physical	11804584
PRP42_YEAST	PRP42	physical	11804584
NAM8_YEAST	NAM8	physical	11804584
SNU56_YEAST	SNU56	physical	11804584
RU17_YEAST	SNP1	physical	11804584
RU1A_YEAST	MUD1	physical	11804584
RU1C_YEAST	YHC1	physical	11804584
LUC7_YEAST	LUC7	physical	11804584
RSE1_YEAST	RSE1	physical	11804584
SF3B1_YEAST	HSH155	physical	11804584
PRP9_YEAST	PRP9	physical	11804584
CUS1_YEAST	CUS1	physical	11804584
PRP21_YEAST	PRP21	physical	11804584
CUS2_YEAST	CUS2	physical	11804584
PRP11_YEAST	PRP11	physical	11804584
RU2A_YEAST	LEA1	physical	11804584
HSH49_YEAST	HSH49	physical	11804584
IST3_YEAST	IST3	physical	11804584
MSL1_YEAST	MSL1	physical	11804584
PRP8_YEAST	PRP8	physical	11804584
BRR2_YEAST	BRR2	physical	11804584
SN114_YEAST	SNU114	physical	11804584
PRP6_YEAST	PRP6	physical	11804584
SNU66_YEAST	SNU66	physical	11804584
PRP31_YEAST	PRP31	physical	11804584
PRP3_YEAST	PRP3	physical	11804584
PRP4_YEAST	PRP4	physical	11804584
SP381_YEAST	SPP381	physical	11804584
PRP38_YEAST	PRP38	physical	11804584
SNU23_YEAST	SNU23	physical	11804584
DIB1_YEAST	DIB1	physical	11804584
SNU13_YEAST	SNU13	physical	11804584
SYF1_YEAST	SYF1	physical	11804584
CLF1_YEAST	CLF1	physical	11804584
CEF1_YEAST	CEF1	physical	11804584
SAD1_YEAST	SAD1	physical	11804584
PRP46_YEAST	PRP46	physical	11804584
PRP45_YEAST	PRP45	physical	11804584
SLT11_YEAST	ECM2	physical	11804584
CWC2_YEAST	CWC2	physical	11804584
ISY1_YEAST	ISY1	physical	11804584
SYF2_YEAST	SYF2	physical	11804584
SN309_YEAST	SNT309	physical	11804584
NTC20_YEAST	NTC20	physical	11804584
RSMB_YEAST	SMB1	physical	11804584
SMD1_YEAST	SMD1	physical	11804584
SMD2_YEAST	SMD2	physical	11804584
SMD3_YEAST	SMD3	physical	11804584
RUXE_YEAST	SME1	physical	11804584
RUXF_YEAST	SMX3	physical	11804584
RUXG_YEAST	SMX2	physical	11804584
LSM2_YEAST	LSM2	physical	11804584
LSM3_YEAST	LSM3	physical	11804584
LSM4_YEAST	LSM4	physical	11804584
LSM6_YEAST	LSM6	physical	11804584
LSM7_YEAST	LSM7	physical	11804584
LSM8_YEAST	LSM8	physical	11804584
SWI4_YEAST	SWI4	physical	11804584
MBP1_YEAST	MBP1	physical	11804584
SWI6_YEAST	SWI6	physical	11804584
XRN1_YEAST	XRN1	physical	11804584
PAT1_YEAST	PAT1	physical	11804584
LSM1_YEAST	LSM1	physical	11804584
DED1_YEAST	DED1	physical	11804584
HSP71_YEAST	SSA1	physical	11804584
SSB1_YEAST	SSB1	physical	11804584
GBLP_YEAST	ASC1	physical	11804584
DHH1_YEAST	DHH1	physical	11804584
IMDH2_YEAST	IMD2	physical	11804584
IMDH3_YEAST	IMD3	physical	11804584
IMDH4_YEAST	IMD4	physical	11804584
FBRL_YEAST	NOP1	physical	11804584
SIS1_YEAST	SIS1	physical	11804584
G3P1_YEAST	TDH1	physical	11804584
PMG1_YEAST	GPM1	physical	11804584
PML1_YEAST	PML1	physical	11804584
BUD31_YEAST	BUD31	physical	11804584
KFA_YEAST	BNA7	physical	11804584
RSSA1_YEAST	RPS0A	physical	11804584
RS3A1_YEAST	RPS1A	physical	11804584
RS2_YEAST	RPS2	physical	11804584
RS3_YEAST	RPS3	physical	11804584
RS5_YEAST	RPS5	physical	11804584
RS7A_YEAST	RPS7A	physical	11804584
RS9B_YEAST	RPS9B	physical	11804584
RS12_YEAST	RPS12	physical	11804584
RS13_YEAST	RPS13	physical	11804584
RS14A_YEAST	RPS14A	physical	11804584
RS16A_YEAST	RPS16B	physical	11804584
RS16B_YEAST	RPS16B	physical	11804584
RS18A_YEAST	RPS18A	physical	11804584
RS18B_YEAST	RPS18A	physical	11804584
RS19B_YEAST	RPS19B	physical	11804584
RS20_YEAST	RPS20	physical	11804584
PRP19_YEAST	PRP19	physical	8194532
CEF1_YEAST	CEF1	physical	11018040
ISY1_YEAST	ISY1	physical	11018040
NTC20_YEAST	NTC20	physical	11018040
RAD14_YEAST	RAD14	genetic	12434004
RLF2_YEAST	RLF2	genetic	12434004
NTC20_YEAST	NTC20	genetic	11018040
ISY1_YEAST	ISY1	genetic	11018040
SN309_YEAST	SNT309	genetic	11018040
SN309_YEAST	SNT309	genetic	9528791
PRP46_YEAST	PRP46	physical	16554755
PRP17_YEAST	CDC40	physical	16429126
CWC2_YEAST	CWC2	physical	16429126
SLT11_YEAST	ECM2	physical	16429126
SF3B1_YEAST	HSH155	physical	16429126
ISY1_YEAST	ISY1	physical	16429126
RU2A_YEAST	LEA1	physical	16429126
PRP45_YEAST	PRP45	physical	16429126
PRP46_YEAST	PRP46	physical	16429126
PRP9_YEAST	PRP9	physical	16429126
SN309_YEAST	SNT309	physical	16429126
SN114_YEAST	SNU114	physical	16429126
BRR2_YEAST	BRR2	physical	16429126
CLF1_YEAST	CLF1	physical	16429126
CWC23_YEAST	CWC23	physical	16429126
SYF1_YEAST	SYF1	physical	16429126
SYF1_YEAST	SYF1	physical	16357217
CEF1_YEAST	CEF1	physical	16357217
CLF1_YEAST	CLF1	physical	16357217
SYF2_YEAST	SYF2	physical	16357217
ISY1_YEAST	ISY1	physical	16357217
SN309_YEAST	SNT309	physical	16357217
NTC20_YEAST	NTC20	physical	16357217
SYF1_YEAST	SYF1	physical	17515604
CEF1_YEAST	CEF1	physical	17515604
CLF1_YEAST	CLF1	physical	17515604
ISY1_YEAST	ISY1	physical	17515604
SN309_YEAST	SNT309	physical	17515604
NTC20_YEAST	NTC20	physical	17515604
CWC16_YEAST	YJU2	physical	17515604
RIC1_YEAST	RIC1	genetic	19061648
PFD6_YEAST	YKE2	genetic	19061648
YPT6_YEAST	YPT6	genetic	19061648
RRP8_YEAST	RRP8	genetic	19061648
HOS2_YEAST	HOS2	genetic	19061648
CWC26_YEAST	BUD13	genetic	19061648
SLX9_YEAST	SLX9	genetic	19061648
SYMM_YEAST	MSM1	genetic	19061648
LTV1_YEAST	LTV1	genetic	19061648
EFTU_YEAST	TUF1	genetic	19061648
MRM1_YEAST	MRM1	genetic	19061648
IST3_YEAST	IST3	genetic	19061648
NCBP1_YEAST	STO1	genetic	19061648
SYKM_YEAST	MSK1	genetic	19061648
PUF4_YEAST	PUF4	genetic	19061648
PAN3_YEAST	PAN3	genetic	19061648
URN1_YEAST	URN1	physical	18719252
SYF1_YEAST	SYF1	physical	19617314
CEF1_YEAST	CEF1	physical	19617314
CLF1_YEAST	CLF1	physical	19617314
SYF2_YEAST	SYF2	physical	19617314
ISY1_YEAST	ISY1	physical	19617314
SN309_YEAST	SNT309	physical	19617314
NTC20_YEAST	NTC20	physical	19617314
SYF1_YEAST	SYF1	physical	19704000
CEF1_YEAST	CEF1	physical	19704000
CLF1_YEAST	CLF1	physical	19704000
ISY1_YEAST	ISY1	physical	19704000
NTC20_YEAST	NTC20	physical	19704000
SYF1_YEAST	SYF1	physical	20956557
CEF1_YEAST	CEF1	physical	20956557
CLF1_YEAST	CLF1	physical	20956557
SYF2_YEAST	SYF2	physical	20956557
ISY1_YEAST	ISY1	physical	20956557
SN309_YEAST	SNT309	physical	20956557
NTC20_YEAST	NTC20	physical	20956557
CWC2_YEAST	CWC2	physical	21386897
PRP17_YEAST	CDC40	physical	21386897
URN1_YEAST	URN1	physical	21386897
MPIP_YEAST	MIH1	physical	21386897
UBA3_YEAST	UBA3	physical	21386897
YP257_YEAST	YPL257W	physical	21386897
UFD4_YEAST	UFD4	physical	21386897
PSB7_YEAST	PRE4	physical	15660529
SPP2_YEAST	SPP2	physical	25561498
PRP2_YEAST	PRP2	physical	25561498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRP19_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND SER-141, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141, AND MASSSPECTROMETRY.	17563356 [Abstract]