SIS1_YEAST - dbPTM
SIS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIS1_YEAST
UniProt AC P25294
Protein Name Protein SIS1
Gene Name SIS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 352
Subcellular Localization Cytoplasm . Nucleus . Localized throughout the cell but is more concentrated at the nucleus.
Protein Description Required for nuclear migration during mitosis. It is required for the normal initiation of translation. Might mediate the dissociation of a specific protein complex of the translation machinery. Essential for viability..
Protein Sequence MVKETKLYDLLGVSPSANEQELKKGYRKAALKYHPDKPTGDTEKFKEISEAFEILNDPQKREIYDQYGLEAARSGGPSFGPGGPGGAGGAGGFPGGAGGFSGGHAFSNEDAFNIFSQFFGGSSPFGGADDSGFSFSSYPSGGGAGMGGMPGGMGGMHGGMGGMPGGFRSASSSPTYPEEETVQVNLPVSLEDLFVGKKKSFKIGRKGPHGASEKTQIDIQLKPGWKAGTKITYKNQGDYNPQTGRRKTLQFVIQEKSHPNFKRDGDDLIYTLPLSFKESLLGFSKTIQTIDGRTLPLSRVQPVQPSQTSTYPGQGMPTPKNPSQRGNLIVKYKVDYPISLNDAQKRAIDENF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Acetylation--MVKETKLYDLLGV
--CCCCCCHHHHHCC		46.2524489116
6Ubiquitination--MVKETKLYDLLGV
--CCCCCCHHHHHCC		46.2517644757
14PhosphorylationLYDLLGVSPSANEQE
HHHHHCCCCCCCHHH		16.0222369663
16PhosphorylationDLLGVSPSANEQELK
HHHCCCCCCCHHHHH		35.9022369663
23AcetylationSANEQELKKGYRKAA
CCCHHHHHHHHHHHH		43.3224489116
23UbiquitinationSANEQELKKGYRKAA
CCCHHHHHHHHHHHH		43.3217644757
24UbiquitinationANEQELKKGYRKAAL
CCHHHHHHHHHHHHH		74.0317644757
32AcetylationGYRKAALKYHPDKPT
HHHHHHHHHCCCCCC		36.4722865919
37AcetylationALKYHPDKPTGDTEK
HHHHCCCCCCCCHHH		49.2622865919
44AcetylationKPTGDTEKFKEISEA
CCCCCHHHHHHHHHH		64.9222865919
46AcetylationTGDTEKFKEISEAFE
CCCHHHHHHHHHHHH		66.2724489116
60AcetylationEILNDPQKREIYDQY
HHHCCHHHHHHHHHH		58.3424489116
169PhosphorylationGMPGGFRSASSSPTY
CCCCCCCCCCCCCCC		30.1822369663
171PhosphorylationPGGFRSASSSPTYPE
CCCCCCCCCCCCCCC		32.3722369663
172PhosphorylationGGFRSASSSPTYPEE
CCCCCCCCCCCCCCC		39.8022369663
173PhosphorylationGFRSASSSPTYPEEE
CCCCCCCCCCCCCCC		20.8322369663
175PhosphorylationRSASSSPTYPEEETV
CCCCCCCCCCCCCEE		54.3722369663
176PhosphorylationSASSSPTYPEEETVQ
CCCCCCCCCCCCEEE		16.4222369663
181PhosphorylationPTYPEEETVQVNLPV
CCCCCCCEEEEECCC		21.3722369663
189PhosphorylationVQVNLPVSLEDLFVG
EEEECCCCHHHHCCC		24.8922369663
222AcetylationTQIDIQLKPGWKAGT
CEEEEEECCCCCCCC		25.7224489116
243PhosphorylationQGDYNPQTGRRKTLQ
CCCCCCCCCCEEEEE		33.6328889911
248PhosphorylationPQTGRRKTLQFVIQE
CCCCCEEEEEEEEEC		24.7928889911
256AcetylationLQFVIQEKSHPNFKR
EEEEEECCCCCCCCC		37.3724489116
271PhosphorylationDGDDLIYTLPLSFKE
CCCCEEEECCCCHHH		18.2024961812
275PhosphorylationLIYTLPLSFKESLLG
EEEECCCCHHHHHHC		32.1225521595
284PhosphorylationKESLLGFSKTIQTID
HHHHHCCCCEEEEEC		27.3921440633
294PhosphorylationIQTIDGRTLPLSRVQ
EEEECCCEEECCCEE		37.9521440633
306PhosphorylationRVQPVQPSQTSTYPG
CEECCCCCCCCCCCC		29.0629136822
308PhosphorylationQPVQPSQTSTYPGQG
ECCCCCCCCCCCCCC		27.6329136822
309PhosphorylationPVQPSQTSTYPGQGM
CCCCCCCCCCCCCCC		20.5029136822
310PhosphorylationVQPSQTSTYPGQGMP
CCCCCCCCCCCCCCC		36.8029136822
311PhosphorylationQPSQTSTYPGQGMPT
CCCCCCCCCCCCCCC		12.7229136822
318PhosphorylationYPGQGMPTPKNPSQR
CCCCCCCCCCCHHHC		37.6923749301
320UbiquitinationGQGMPTPKNPSQRGN
CCCCCCCCCHHHCCC		81.5723749301
331AcetylationQRGNLIVKYKVDYPI
HCCCEEEEEEEECCC		32.1524489116
333AcetylationGNLIVKYKVDYPISL
CCEEEEEEEECCCCC		23.9424489116
333SuccinylationGNLIVKYKVDYPISL
CCEEEEEEEECCCCC		23.9423954790
339PhosphorylationYKVDYPISLNDAQKR
EEEECCCCCCHHHHH		19.3322369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC24_YEASTCDC24physical
11805826
HSP42_YEASTHSP42physical
11805826
RNQ1_YEASTRNQ1physical
14657253
HSP71_YEASTSSA1physical
11279042
HSP71_YEASTSSA1physical
15687271
MAS5_YEASTYDJ1genetic
11266475
LSP1_YEASTLSP1physical
18467557
SIS1_YEASTSIS1physical
18467557
RNQ1_YEASTRNQ1physical
18480252
SIS1_YEASTSIS1physical
10997899
SIS1_YEASTSIS1physical
18723025
HSP71_YEASTSSA1physical
18706386
CHD1_YEASTCHD1physical
19536198
HSP72_YEASTSSA2physical
19536198
SSB1_YEASTSSB1physical
19536198
HSP7F_YEASTSSE1physical
19536198
RNQ1_YEASTRNQ1physical
18332119
AIM3_YEASTAIM3genetic
21035341
RNQ1_YEASTRNQ1genetic
22529103
BTN2_YEASTBTN2physical
22718905
CUR1_YEASTCUR1physical
22718905
SAN1_YEASTSAN1genetic
23341891
UBR1_YEASTUBR1genetic
23341891
HS104_YEASTHSP104genetic
23341891
HSP42_YEASTHSP42genetic
24938787
BTN2_YEASTBTN2genetic
24938787
CUR1_YEASTCUR1genetic
24938787
HSP71_YEASTSSA1physical
23791384
CBPY_YEASTPRC1physical
23791384
STI1_YEASTSTI1genetic
24109600
HSP71_YEASTSSA1physical
23227221
SIS1_YEASTSIS1physical
23227221
HSP71_YEASTSSA1physical
25687964
MAS5_YEASTYDJ1genetic
29084221
HSP71_YEASTSSA1genetic
29084221
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-173, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND MASSSPECTROMETRY.

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