| UniProt ID | UBR1_YEAST | |
|---|---|---|
| UniProt AC | P19812 | |
| Protein Name | E3 ubiquitin-protein ligase UBR1 | |
| Gene Name | UBR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1950 | |
| Subcellular Localization | ||
| Protein Description | Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.. | |
| Protein Sequence | MSVADDDLGSLQGHIRRTLRSIHNLPYFRYTRGPTERADMSRALKEFIYRYLYFVISNSGENLPTLFNAHPKQKLSNPELTVFPDSLEDAVDIDKITSQQTIPFYKIDESRIGDVHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKEEDVWNDSVNIALVELVLAEVFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDEYHNYSQATTALRQGVPDNVHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWITHCLNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILADGNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFDNRYWKRLRKDIQNVIIPTLASSNLYKPIFCQQVVEIFNHITRSVAYMDREPQLTAIRECVVQLFTCPTNAKNIFENQSFLDIVWSIIDIFKEFCKVEGGVLIWQRVQKSNLTKSYSISFKQGLYTVETLLSKVHDPNIPLRPKEIISLLTLCKLFNGAWKIKRKEGEHVLHEDQNFISYLEYTTSIYSIIQTAEKVSEKSKDSIDSKLFLNAIRIISSFLGNRSLTYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSLKDAYEALEDCSDFLKISDFSLRSVVLCSQIDVGFWVRNGMSVLHQASYYKNNPELGSYSRDIHLNQLAILWERDDIPRIIYNILDRWELLDWFTGEVDYQHTVYEDKISFIIQQFIAFIYQILTERQYFKTFSSLKDRRMDQIKNSIIYNLYMKPLSYSKLLRSVPDYLTEDTTEFDEALEEVSVFVEPKGLADNGVFKLKASLYAKVDPLKLLNLENEFESSATIIKSHLAKDKDEIAKVVLIPQVSIKQLDKDALNLGAFTRNTVFAKVVYKLLQVCLDMEDSTFLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIANAKSDVFSESIVRKADYLLEKMIMKKPNELFESLIASFGNQYVNDYKDKKLRQGVNLQETEKERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFDEQDNDVDMVGEKVYESEDFTCALCQDSSSTDFFVIPAYHDHSPIFRPGNIFNPNEFMPMWDGFYNDDEKQAYIDDDVLEALKENGSCGSRKVFVSCNHHIHHNCFKRYVQKKRFSSNAFICPLCQTFSNCTLPLCQTSKANTGLSLDMFLESELSLDTLSRLFKPFTEENYRTINSIFSLMISQCQGFDKAVRKRANFSHKDVSLILSVHWANTISMLEIASRLEKPYSISFFRSREQKYKTLKNILVCIMLFTFVIGKPSMEFEPYPQQPDTVWNQNQLFQYIVRSALFSPVSLRQTVTEALTTFSRQFLRDFLQGLSDAEQVTKLYAKASKIGDVLKVSEQMLFALRTISDVRMEGLDSESIIYDLAYTFLLKSLLPTIRRCLVFIKVLHELVKDSENETLVINGHEVEEELEFEDTAEFVNKALKMITEKESLVDLLTTQESIVSHPYLENIPYEYCGIIKLIDLSKYLNTYVTQSKEIKLREERSQHMKNADNRLDFKICLTCGVKVHLRADRHEMTKHLNKNCFKPFGAFLMPNSSEVCLHLTQPPSNIFISAPYLNSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNEIPGYISRVMGDEFRVTILSNGFLFAFNREPRPRRIPPTDEDDEDMEEGEDGFFTEGNDEMDVDDETGQAANLFGVGAEGIAGGGVRDFFQFFENFRNTLQPQGNGDDDAPQNPPPILQFLGPQFDGATIIRNTNPRNLDEDDSDDNDDSDEREIW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSVADDDLG ------CCCCCCCHH | 37.00 | 22369663 | |
| 45 | Acetylation | ADMSRALKEFIYRYL CHHHHHHHHHHHHHH | 49.98 | 24489116 | |
| 72 | Ubiquitination | TLFNAHPKQKLSNPE CCCCCCCCCCCCCCC | 50.64 | 17644757 | |
| 74 | Ubiquitination | FNAHPKQKLSNPELT CCCCCCCCCCCCCCE | 61.07 | 17644757 | |
| 95 | Ubiquitination | EDAVDIDKITSQQTI HHCCCHHHCCCCCEE | 48.49 | 17644757 | |
| 277 | Phosphorylation | QFLNDLKYENDYMFD HHHHHCCCCCCCEEC | 27.54 | 22369663 | |
| 281 | Phosphorylation | DLKYENDYMFDGTTT HCCCCCCCEECCCCC | 15.97 | 22369663 | |
| 286 | Phosphorylation | NDYMFDGTTTAKTSP CCCEECCCCCCCCCC | 23.87 | 20377248 | |
| 287 | Phosphorylation | DYMFDGTTTAKTSPS CCEECCCCCCCCCCC | 30.22 | 22369663 | |
| 288 | Phosphorylation | YMFDGTTTAKTSPSN CEECCCCCCCCCCCC | 26.45 | 22369663 | |
| 291 | Phosphorylation | DGTTTAKTSPSNSPE CCCCCCCCCCCCCCC | 43.32 | 22369663 | |
| 292 | Phosphorylation | GTTTAKTSPSNSPEA CCCCCCCCCCCCCCC | 26.14 | 22369663 | |
| 294 | Phosphorylation | TTAKTSPSNSPEASP CCCCCCCCCCCCCCC | 50.10 | 20377248 | |
| 296 | Phosphorylation | AKTSPSNSPEASPSL CCCCCCCCCCCCCCC | 28.58 | 22369663 | |
| 300 | Phosphorylation | PSNSPEASPSLAKID CCCCCCCCCCCCCCC | 17.23 | 22369663 | |
| 302 | Phosphorylation | NSPEASPSLAKIDPE CCCCCCCCCCCCCCC | 38.16 | 22369663 | |
| 420 | Ubiquitination | TFRNMMGKTLCSEYL HHHHHHCHHHHHHHH | 22.04 | 17644757 | |
| 441 | Ubiquitination | DMTPVVEKYFSNKFD CCHHHHHHHHCCCCC | 39.73 | 17644757 | |
| 446 | Ubiquitination | VEKYFSNKFDKNDPY HHHHHCCCCCCCCCC | 54.46 | 17644757 | |
| 449 | Ubiquitination | YFSNKFDKNDPYRYI HHCCCCCCCCCCCEE | 67.40 | 17644757 | |
| 453 | Phosphorylation | KFDKNDPYRYIDLSI CCCCCCCCCEEEEEE | 20.93 | 19823750 | |
| 455 | Phosphorylation | DKNDPYRYIDLSILA CCCCCCCEEEEEEEE | 7.92 | 19823750 | |
| 459 | Phosphorylation | PYRYIDLSILADGNQ CCCEEEEEEEECCCC | 16.29 | 19823750 | |
| 473 | Ubiquitination | QIPLGHHKILPESST CCCCCCCCCCCCCCC | 40.02 | 17644757 | |
| 492 | Phosphorylation | PLINDVETPTSRTYS CCCCCCCCCCCCCCC | 31.54 | 23749301 | |
| 515 | Ubiquitination | YFDNRYWKRLRKDIQ EECHHHHHHHHHHHH | 32.40 | 17644757 | |
| 581 | Ubiquitination | FTCPTNAKNIFENQS HCCCCCCCHHHCCHH | 53.28 | 17644757 | |
| 619 | Phosphorylation | IWQRVQKSNLTKSYS EEEEEHHCCCCEEEE | 21.71 | 27017623 | |
| 626 | Phosphorylation | SNLTKSYSISFKQGL CCCCEEEEEEECCCE | 20.88 | 27017623 | |
| 688 | Phosphorylation | HEDQNFISYLEYTTS ECCCCHHHHHHHHHH | 21.37 | 27017623 | |
| 689 | Phosphorylation | EDQNFISYLEYTTSI CCCCHHHHHHHHHHH | 9.95 | 27017623 | |
| 692 | Phosphorylation | NFISYLEYTTSIYSI CHHHHHHHHHHHHHH | 16.84 | 27017623 | |
| 693 | Phosphorylation | FISYLEYTTSIYSII HHHHHHHHHHHHHHH | 12.51 | 27017623 | |
| 698 | Phosphorylation | EYTTSIYSIIQTAEK HHHHHHHHHHHHHHH | 16.14 | 27017623 | |
| 702 | Phosphorylation | SIYSIIQTAEKVSEK HHHHHHHHHHHHCHH | 26.78 | 27017623 | |
| 774 | Phosphorylation | SFLIEKVSLKDAYEA HHHHHHCCHHHHHHH | 40.55 | 27017623 | |
| 792 | Phosphorylation | CSDFLKISDFSLRSV CCHHHHHCCCCCCCE | 30.89 | 27017623 | |
| 795 | Phosphorylation | FLKISDFSLRSVVLC HHHHCCCCCCCEEEE | 28.06 | 27017623 | |
| 832 | Phosphorylation | KNNPELGSYSRDIHL CCCCCCCCCCCCEEH | 32.34 | 30377154 | |
| 919 | Ubiquitination | DRRMDQIKNSIIYNL HHCHHHHHHHHHHHH | 38.72 | 17644757 | |
| 929 | Ubiquitination | IIYNLYMKPLSYSKL HHHHHHCCCCCHHHH | 29.29 | 17644757 | |
| 935 | Ubiquitination | MKPLSYSKLLRSVPD CCCCCHHHHHHCCCC | 43.22 | 17644757 | |
| 965 | Ubiquitination | VSVFVEPKGLADNGV CEEEECCCCCCCCCE | 53.72 | 17644757 | |
| 974 | Acetylation | LADNGVFKLKASLYA CCCCCEEEEEEEEEE | 46.82 | 24489116 | |
| 982 | Acetylation | LKASLYAKVDPLKLL EEEEEEEECCHHHHC | 33.35 | 24489116 | |
| 1003 | Ubiquitination | ESSATIIKSHLAKDK HHHHHHHHHHHCCCH | 28.15 | 17644757 | |
| 1008 | Ubiquitination | IIKSHLAKDKDEIAK HHHHHHCCCHHHHCC | 72.21 | 17644757 | |
| 1010 | Ubiquitination | KSHLAKDKDEIAKVV HHHHCCCHHHHCCEE | 57.46 | 17644757 | |
| 1015 | Ubiquitination | KDKDEIAKVVLIPQV CCHHHHCCEEEECCC | 38.24 | 17644757 | |
| 1015 | Acetylation | KDKDEIAKVVLIPQV CCHHHHCCEEEECCC | 38.24 | 24489116 | |
| 1029 | Acetylation | VSIKQLDKDALNLGA CCHHHCCHHHHHCCC | 54.19 | 24489116 | |
| 1106 | Ubiquitination | LLSIANAKSDVFSES HHHHHHCCCCCCCHH | 47.17 | 17644757 | |
| 1117 | Ubiquitination | FSESIVRKADYLLEK CCHHHHHHHHHHHHH | 34.41 | 17644757 | |
| 1128 | Ubiquitination | LLEKMIMKKPNELFE HHHHHHCCCHHHHHH | 54.90 | 17644757 | |
| 1129 | Ubiquitination | LEKMIMKKPNELFES HHHHHCCCHHHHHHH | 35.38 | 17644757 | |
| 1150 | Ubiquitination | NQYVNDYKDKKLRQG HHHHHHHHCHHHHCC | 66.97 | 17644757 | |
| 1152 | Ubiquitination | YVNDYKDKKLRQGVN HHHHHHCHHHHCCCC | 49.94 | 17644757 | |
| 1153 | Ubiquitination | VNDYKDKKLRQGVNL HHHHHCHHHHCCCCH | 60.06 | 17644757 | |
| 1165 | Ubiquitination | VNLQETEKERKRRLA CCHHHHHHHHHHHHH | 70.95 | 17644757 | |
| 1168 | Ubiquitination | QETEKERKRRLAKKH HHHHHHHHHHHHHHH | 42.85 | 17644757 | |
| 1182 | Acetylation | HQARLLAKFNNQQTK HHHHHHHHHCHHHHH | 48.90 | 22865919 | |
| 1192 | Ubiquitination | NQQTKFMKEHESEFD HHHHHHHHHHHHHCC | 60.08 | 23749301 | |
| 1196 | Phosphorylation | KFMKEHESEFDEQDN HHHHHHHHHCCCCCC | 45.53 | 22369663 | |
| 1338 | Ubiquitination | LPLCQTSKANTGLSL CCCCCCCCCCCCCCH | 49.39 | 17644757 | |
| 1363 | Ubiquitination | DTLSRLFKPFTEENY HHHHHHHCCCCHHHH | 43.76 | 17644757 | |
| 1389 | Ubiquitination | SQCQGFDKAVRKRAN HHCCCHHHHHHHHCC | 46.66 | 17644757 | |
| 1398 | Phosphorylation | VRKRANFSHKDVSLI HHHHCCCCCCCHHHE | 29.45 | 23607784 | |
| 1425 | Acetylation | EIASRLEKPYSISFF HHHHHCCCCCEECEE | 54.57 | 24489116 | |
| 1525 | Ubiquitination | SDAEQVTKLYAKASK CCHHHHHHHHHHHHC | 40.41 | 24961812 | |
| 1679 | Ubiquitination | NTYVTQSKEIKLREE HHHHHHCHHHHHHHH | 54.35 | 23749301 | |
| 1720 | Phosphorylation | RADRHEMTKHLNKNC CCCHHHHHHHHCCCC | 16.60 | 28889911 | |
| 1782 | Ubiquitination | DLTTLNLKRYEHLNR CCCCCCCCCHHHHHH | 52.43 | 17644757 | |
| 1938 | Phosphorylation | RNLDEDDSDDNDDSD CCCCCCCCCCCCCCC | 60.22 | 22369663 | |
| 1944 | Phosphorylation | DSDDNDDSDEREIW- CCCCCCCCCCCCCC- | 44.21 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-288; THR-291; SER-292;SER-296; SER-300 AND THR-1720, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296 AND SER-300, ANDMASS SPECTROMETRY. | |
