6PGD1_YEAST - dbPTM
6PGD1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 6PGD1_YEAST
UniProt AC P38720
Protein Name 6-phosphogluconate dehydrogenase, decarboxylating 1
Gene Name GND1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 489
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH..
Protein Sequence MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDNLPVDKDIHINWTGHGGNVSSSTYQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationCAYNRTQSKVDHFLA
EEEECCHHHHHHHHH		33.7530377154
37AcetylationAYNRTQSKVDHFLAN
EEECCHHHHHHHHHC		41.6924489116
37UbiquitinationAYNRTQSKVDHFLAN
EEECCHHHHHHHHHC		41.6923749301
37SuccinylationAYNRTQSKVDHFLAN
EEECCHHHHHHHHHC		41.6923954790
472-HydroxyisobutyrylationHFLANEAKGKSIIGA
HHHHCHHCCCCEECC		61.77-
47UbiquitinationHFLANEAKGKSIIGA
HHHHCHHCCCCEECC		61.7717644757
47AcetylationHFLANEAKGKSIIGA
HHHHCHHCCCCEECC		61.7722865919
49UbiquitinationLANEAKGKSIIGATS
HHCHHCCCCEECCCC		37.4617644757
50PhosphorylationANEAKGKSIIGATSI
HCHHCCCCEECCCCH		28.2721440633
55PhosphorylationGKSIIGATSIEDFIS
CCCEECCCCHHHHHH		25.6424961812
56PhosphorylationKSIIGATSIEDFISK
CCEECCCCHHHHHHH		24.3624961812
62PhosphorylationTSIEDFISKLKRPRK
CCHHHHHHHCCCCCE		31.7430377154
63UbiquitinationSIEDFISKLKRPRKV
CHHHHHHHCCCCCEE		53.8917644757
63AcetylationSIEDFISKLKRPRKV
CHHHHHHHCCCCCEE		53.8924489116
65UbiquitinationEDFISKLKRPRKVML
HHHHHHCCCCCEEEE		65.1817644757
75UbiquitinationRKVMLLVKAGAPVDA
CEEEEEEECCCCHHH		40.8619722269
116AcetylationNRRYEELKKKGILFV
CHHHHHHHHCCEEEE		56.5725381059
117UbiquitinationRRYEELKKKGILFVG
HHHHHHHHCCEEEEC		69.7117644757
118UbiquitinationRYEELKKKGILFVGS
HHHHHHHCCEEEECC		49.9817644757
128PhosphorylationLFVGSGVSGGEEGAR
EEECCCCCCCCCCCC		44.6028889911
145PhosphorylationPSLMPGGSEEAWPHI
CCCCCCCCHHHHHHH		37.8721082442
153UbiquitinationEEAWPHIKNIFQSIS
HHHHHHHHHHHHHHH		40.7417644757
153AcetylationEEAWPHIKNIFQSIS
HHHHHHHHHHHHHHH		40.7424489116
158PhosphorylationHIKNIFQSISAKSDG
HHHHHHHHHHCCCCC		14.0422369663
160PhosphorylationKNIFQSISAKSDGEP
HHHHHHHHCCCCCCC		34.5922369663
162UbiquitinationIFQSISAKSDGEPCC
HHHHHHCCCCCCCCC		42.1417644757
163PhosphorylationFQSISAKSDGEPCCE
HHHHHCCCCCCCCCC		51.0321440633
182UbiquitinationAGAGHYVKMVHNGIE
CCCCCCEEEEECCCC		28.2117644757
212AcetylationRLGGFTDKEISDVFA
HHCCCCCHHHHHHHH		54.6224489116
239AcetylationEITRDILKFDDVDGK
HHHHHHHCCCCCCCC		47.2624489116
2392-HydroxyisobutyrylationEITRDILKFDDVDGK
HHHHHHHCCCCCCCC		47.26-
239UbiquitinationEITRDILKFDDVDGK
HHHHHHHCCCCCCCC		47.2617644757
2462-HydroxyisobutyrylationKFDDVDGKPLVEKIM
CCCCCCCCCHHHHHH		30.62-
246AcetylationKFDDVDGKPLVEKIM
CCCCCCCCCHHHHHH		30.6224489116
246UbiquitinationKFDDVDGKPLVEKIM
CCCCCCCCCHHHHHH		30.6223749301
251AcetylationDGKPLVEKIMDTAGQ
CCCCHHHHHHHCCCC		35.5324489116
251UbiquitinationDGKPLVEKIMDTAGQ
CCCCHHHHHHHCCCC		35.5317644757
259UbiquitinationIMDTAGQKGTGKWTA
HHHCCCCCCCCCCCH		58.4823749301
2592-HydroxyisobutyrylationIMDTAGQKGTGKWTA
HHHCCCCCCCCCCCH		58.48-
259SuccinylationIMDTAGQKGTGKWTA
HHHCCCCCCCCCCCH		58.4823954790
263UbiquitinationAGQKGTGKWTAINAL
CCCCCCCCCCHHHHH		41.0123749301
289PhosphorylationAVFARCLSALKNERI
HHHHHHHHHHHCCCC		34.8723749301
292UbiquitinationARCLSALKNERIRAS
HHHHHHHHCCCCCHH		57.3823749301
292AcetylationARCLSALKNERIRAS
HHHHHHHHCCCCCHH		57.3825381059
292SuccinylationARCLSALKNERIRAS
HHHHHHHHCCCCCHH		57.3823954790
300SuccinylationNERIRASKVLPGPEV
CCCCCHHCCCCCCCC		46.9723954790
309AcetylationLPGPEVPKDAVKDRE
CCCCCCCHHHHCCHH		64.5924489116
309SuccinylationLPGPEVPKDAVKDRE
CCCCCCCHHHHCCHH		64.5923954790
3092-HydroxyisobutyrylationLPGPEVPKDAVKDRE
CCCCCCCHHHHCCHH		64.59-
313AcetylationEVPKDAVKDREQFVD
CCCHHHHCCHHHHHH		53.4324489116
313SuccinylationEVPKDAVKDREQFVD
CCCHHHHCCHHHHHH		53.4323954790
330UbiquitinationEQALYASKIISYAQG
HHHHHHHHHHHHHHH		35.5717644757
351UbiquitinationAAATYGWKLNNPAIA
HHHHHCCCCCCHHHH		36.6517644757
377AcetylationVFLGQITKAYREEPD
HHHHHHHHHHHHCCC		45.0824489116
4002-HydroxyisobutyrylationFFADAVTKAQSGWRK
HHHHHHHHHHHCHHH		37.52-
400AcetylationFFADAVTKAQSGWRK
HHHHHHHHHHHCHHH		37.5224489116
408PhosphorylationAQSGWRKSIALATTY
HHHCHHHHHHHHHHC		12.4322369663
413PhosphorylationRKSIALATTYGIPTP
HHHHHHHHHCCCCCH		22.7722369663
414PhosphorylationKSIALATTYGIPTPA
HHHHHHHHCCCCCHH		17.7222369663
415PhosphorylationSIALATTYGIPTPAF
HHHHHHHCCCCCHHH		14.5422369663
419PhosphorylationATTYGIPTPAFSTAL
HHHCCCCCHHHHHHH		25.9022369663
423PhosphorylationGIPTPAFSTALSFYD
CCCCHHHHHHHHHHH		18.1922369663
424PhosphorylationIPTPAFSTALSFYDG
CCCHHHHHHHHHHHC		25.7622369663
427PhosphorylationPAFSTALSFYDGYRS
HHHHHHHHHHHCCCC		21.2122369663
429PhosphorylationFSTALSFYDGYRSER
HHHHHHHHHCCCCCC		12.7022369663
432PhosphorylationALSFYDGYRSERLPA
HHHHHHCCCCCCCCH		14.2022369663
462PhosphorylationRVLPECASDNLPVDK
EECHHHHCCCCCCCC		38.4028889911
476PhosphorylationKDIHINWTGHGGNVS
CCEEEECCCCCCCCC		18.1422369663
483PhosphorylationTGHGGNVSSSTYQA-
CCCCCCCCCCCCCC-		23.6721440633
484PhosphorylationGHGGNVSSSTYQA--
CCCCCCCCCCCCC--		23.5522369663
485PhosphorylationHGGNVSSSTYQA---
CCCCCCCCCCCC---		24.5122369663
486PhosphorylationGGNVSSSTYQA----
CCCCCCCCCCC----		22.9222369663
487PhosphorylationGNVSSSTYQA-----
CCCCCCCCCC-----		12.3722369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of 6PGD1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 6PGD1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 6PGD1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDHM_YEASTMDH1physical
11805837
EF3B_YEASTHEF3physical
11805837
KIP3_YEASTKIP3physical
11805837
6PGD2_YEASTGND2physical
16554755
6PGD1_YEASTGND1physical
17570834
6PGD2_YEASTGND2genetic
18408719
6PGD2_YEASTGND2genetic
16941010
RPE_YEASTRPE1genetic
16941010
TKT1_YEASTTKL1genetic
16941010
TKT2_YEASTTKL2genetic
16941010
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 6PGD1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.

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