6PGD2_YEAST - dbPTM
6PGD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 6PGD2_YEAST
UniProt AC P53319
Protein Name 6-phosphogluconate dehydrogenase, decarboxylating 2
Gene Name GND2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 492
Subcellular Localization
Protein Description Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH..
Protein Sequence MSKAVGDLGLVGLAVMGQNLILNAADHGFTVVAYNRTQSKVDRFLANEAKGKSIIGATSIEDLVAKLKKPRKIMLLIKAGAPVDTLIKELVPHLDKGDIIIDGGNSHFPDTNRRYEELTKQGILFVGSGVSGGEDGARFGPSLMPGGSAEAWPHIKNIFQSIAAKSNGEPCCEWVGPAGSGHYVKMVHNGIEYGDMQLICEAYDIMKRIGRFTDKEISEVFDKWNTGVLDSFLIEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSAIKDERKRASKLLAGPTVPKDAIHDREQFVYDLEQALYASKIISYAQGFMLIREAARSYGWKLNNPAIALMWRGGCIIRSVFLAEITKAYRDDPDLENLLFNEFFASAVTKAQSGWRRTIALAATYGIPTPAFSTALAFYDGYRSERLPANLLQAQRDYFGAHTFRILPECASAHLPVDKDIHINWTGHGGNISSSTYQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationANEAKGKSIIGATSI
HHHHCCCCEECCCCH		28.2719779198
58PhosphorylationGKSIIGATSIEDLVA
CCCEECCCCHHHHHH		25.6429136822
59PhosphorylationKSIIGATSIEDLVAK
CCEECCCCHHHHHHH		24.3629136822
242UbiquitinationEITRDILKFDDVDGK
HHHHHHHCCCCCCCC		47.2617644757
249UbiquitinationKFDDVDGKPLVEKIM
CCCCCCCCCHHHHHH		30.6223749301
254UbiquitinationDGKPLVEKIMDTAGQ
CCCCHHHHHHHCCCC		35.5317644757
262UbiquitinationIMDTAGQKGTGKWTA
HHHCCCCCCCCCCCH		58.4823749301
266UbiquitinationAGQKGTGKWTAINAL
CCCCCCCCCCHHHHH		41.0123749301
333UbiquitinationEQALYASKIISYAQG
HHHHHHHHHHHHHHH		35.5717644757
354UbiquitinationAARSYGWKLNNPAIA
HHHHCCCCCCCHHHH		36.6517644757
372PhosphorylationRGGCIIRSVFLAEIT
CCCHHHHHHHHHHHH		13.5522369663
379PhosphorylationSVFLAEITKAYRDDP
HHHHHHHHHHHCCCC		10.9222369663
418PhosphorylationTIALAATYGIPTPAF
HHHHHHHHCCCCCHH		14.3429650682
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of 6PGD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 6PGD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 6PGD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
6PGD2_YEASTGND2physical
18467557
RPE_YEASTRPE1genetic
16941010
TKT1_YEASTTKL1genetic
16941010
TKT2_YEASTTKL2genetic
16941010
6PGD1_YEASTGND1genetic
21623372
INP54_YEASTINP54genetic
21623372
MET22_YEASTMET22genetic
21623372
COX7_YEASTCOX7genetic
21623372
INO4_YEASTINO4genetic
27708008
PAD1_YEASTPAD1genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
PEX14_YEASTPEX14genetic
27708008
PEX2_YEASTPEX2genetic
27708008
PEX13_YEASTPEX13genetic
27708008
SST2_YEASTSST2genetic
27708008
PALI_YEASTRIM9genetic
27708008
PEX15_YEASTPEX15genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 6PGD2_YEAST

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Related Literatures of Post-Translational Modification

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