| UniProt ID | PEX14_YEAST | |
|---|---|---|
| UniProt AC | P53112 | |
| Protein Name | Peroxisomal membrane protein PEX14 | |
| Gene Name | PEX14 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 341 | |
| Subcellular Localization |
Peroxisome membrane Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.. | |
| Protein Sequence | MSDVVSKDRKALFDSAVSFLKDESIKDAPLLKKIEFLKSKGLTEKEIEIAMKEPKKDGIVGDEVSKKIGSTENRASQDMYLYEAMPPTLPHRDWKDYFVMATATAGLLYGAYEVTRRYVIPNILPEAKSKLEGDKKEIDDQFSKIDTVLNAIEAEQAEFRKKESETLKELSDTIAELKQALVQTTRSREKIEDEFRIVKLEVVNMQNTIDKFVSDNDGMQELNNIQKEMESLKSLMNNRMESGNAQDNRLFSISPNGIPGIDTIPSASEILAKMGMQEESDKEKENGSDANKDDNAVPAWKKAREQTIDSNASIPEWQKNTAANEISVPDWQNGQVEDSIP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSDVVSKDR ------CCCCCCHHH | 38.83 | 22814378 | |
| 7 | Ubiquitination | -MSDVVSKDRKALFD -CCCCCCHHHHHHHH | 50.36 | 24961812 | |
| 10 | Ubiquitination | DVVSKDRKALFDSAV CCCCHHHHHHHHHHH | 60.62 | 24961812 | |
| 21 | Ubiquitination | DSAVSFLKDESIKDA HHHHHHHCCCCCCCC | 58.39 | 24961812 | |
| 24 | Phosphorylation | VSFLKDESIKDAPLL HHHHCCCCCCCCCHH | 45.10 | 28889911 | |
| 26 | Ubiquitination | FLKDESIKDAPLLKK HHCCCCCCCCCHHHH | 58.05 | 23749301 | |
| 32 | Ubiquitination | IKDAPLLKKIEFLKS CCCCCHHHHHHHHHH | 60.43 | 17644757 | |
| 33 | Ubiquitination | KDAPLLKKIEFLKSK CCCCHHHHHHHHHHC | 47.65 | 17644757 | |
| 55 | Ubiquitination | EIAMKEPKKDGIVGD HHHCCCCCCCCCCCH | 65.67 | 17644757 | |
| 56 | Ubiquitination | IAMKEPKKDGIVGDE HHCCCCCCCCCCCHH | 72.42 | 17644757 | |
| 65 | Phosphorylation | GIVGDEVSKKIGSTE CCCCHHHHHHCCCCC | 26.61 | 21440633 | |
| 66 | Ubiquitination | IVGDEVSKKIGSTEN CCCHHHHHHCCCCCC | 54.29 | 17644757 | |
| 67 | Ubiquitination | VGDEVSKKIGSTENR CCHHHHHHCCCCCCC | 44.80 | 17644757 | |
| 136 | Ubiquitination | SKLEGDKKEIDDQFS HHHCCCHHHHHHHHH | 65.72 | 17644757 | |
| 143 | Phosphorylation | KEIDDQFSKIDTVLN HHHHHHHHHHHHHHH | 24.06 | 19795423 | |
| 144 | Ubiquitination | EIDDQFSKIDTVLNA HHHHHHHHHHHHHHH | 45.98 | 17644757 | |
| 161 | Ubiquitination | AEQAEFRKKESETLK HHHHHHHHHHHHHHH | 67.24 | 17644757 | |
| 162 | Ubiquitination | EQAEFRKKESETLKE HHHHHHHHHHHHHHH | 63.32 | 17644757 | |
| 168 | Ubiquitination | KKESETLKELSDTIA HHHHHHHHHHHHHHH | 65.12 | 17644757 | |
| 178 | Ubiquitination | SDTIAELKQALVQTT HHHHHHHHHHHHHHH | 25.65 | 17644757 | |
| 234 | Phosphorylation | KEMESLKSLMNNRME HHHHHHHHHHHHCHH | 37.84 | 21440633 | |
| 242 | Phosphorylation | LMNNRMESGNAQDNR HHHHCHHCCCCCCCC | 28.18 | 27214570 | |
| 252 | Phosphorylation | AQDNRLFSISPNGIP CCCCCCEEECCCCCC | 27.09 | 30377154 | |
| 254 | Phosphorylation | DNRLFSISPNGIPGI CCCCEEECCCCCCCC | 15.89 | 30377154 | |
| 266 | Phosphorylation | PGIDTIPSASEILAK CCCCCCCCHHHHHHH | 40.34 | 28889911 | |
| 273 | Ubiquitination | SASEILAKMGMQEES CHHHHHHHCCCCCCH | 32.32 | 17644757 | |
| 280 | Phosphorylation | KMGMQEESDKEKENG HCCCCCCHHHHHHCC | 53.91 | 24909858 | |
| 288 | Phosphorylation | DKEKENGSDANKDDN HHHHHCCCCCCCCCC | 45.17 | 22369663 | |
| 307 | Phosphorylation | WKKAREQTIDSNASI HHHHHHHHCCCCCCC | 23.23 | 22369663 | |
| 310 | Phosphorylation | AREQTIDSNASIPEW HHHHHCCCCCCCCHH | 30.37 | 22369663 | |
| 313 | Phosphorylation | QTIDSNASIPEWQKN HHCCCCCCCCHHHHC | 42.82 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PEX14_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PEX14_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEX14_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266 AND SER-313, ANDMASS SPECTROMETRY. | |
