| UniProt ID | MKK1_YEAST | |
|---|---|---|
| UniProt AC | P32490 | |
| Protein Name | MAP kinase kinase MKK1/SSP32 | |
| Gene Name | MKK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 508 | |
| Subcellular Localization | ||
| Protein Description | Involved in a signal transduction pathway that play a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.. | |
| Protein Sequence | MASLFRPPESAKCNPNSPRLKLPLLRNNQVDENNIYLTSNGSSTTAYSSHTPEPLTSSTSTLFSQTRLHPSDSSMTLNTMKKRPAPPSLPSLSINSQSKCKTLPELVPIADVSDGKHDLGLKQRVIAENELSGNSDLTPSSMASPFSHTNTSSPYLRNDLSNSVGSDFSNLISAYEQSSSPIKSSSQPKSSSESYIDLNSVRDVDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIKGQMKKNVNMEKFVRKCWKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASLFRPPES -----CCCCCCCCHH | 27.09 | 19823750 | |
| 17 | Phosphorylation | SAKCNPNSPRLKLPL HHCCCCCCCCCCCCC | 16.80 | 28889911 | |
| 71 | Phosphorylation | SQTRLHPSDSSMTLN CCCCCCCCCCCCCHH | 39.10 | 22369663 | |
| 73 | Phosphorylation | TRLHPSDSSMTLNTM CCCCCCCCCCCHHHC | 26.75 | 22369663 | |
| 74 | Phosphorylation | RLHPSDSSMTLNTMK CCCCCCCCCCHHHCC | 22.30 | 22369663 | |
| 76 | Phosphorylation | HPSDSSMTLNTMKKR CCCCCCCCHHHCCCC | 20.85 | 22369663 | |
| 79 | Phosphorylation | DSSMTLNTMKKRPAP CCCCCHHHCCCCCCC | 33.22 | 30377154 | |
| 113 | Phosphorylation | LVPIADVSDGKHDLG CEEEECCCCCCCCCC | 40.99 | 21551504 | |
| 141 | Phosphorylation | NSDLTPSSMASPFSH CCCCCHHHHCCCCCC | 21.41 | 19779198 | |
| 144 | Phosphorylation | LTPSSMASPFSHTNT CCHHHHCCCCCCCCC | 20.17 | 28889911 | |
| 147 | Phosphorylation | SSMASPFSHTNTSSP HHHCCCCCCCCCCCH | 32.55 | 19779198 | |
| 149 | Phosphorylation | MASPFSHTNTSSPYL HCCCCCCCCCCCHHH | 38.71 | 19779198 | |
| 151 | Phosphorylation | SPFSHTNTSSPYLRN CCCCCCCCCCHHHHH | 31.56 | 19779198 | |
| 152 | Phosphorylation | PFSHTNTSSPYLRND CCCCCCCCCHHHHHH | 31.24 | 28889911 | |
| 153 | Phosphorylation | FSHTNTSSPYLRNDL CCCCCCCCHHHHHHH | 18.61 | 19779198 | |
| 161 | Phosphorylation | PYLRNDLSNSVGSDF HHHHHHHCCCCCCCH | 29.89 | 30377154 | |
| 163 | Phosphorylation | LRNDLSNSVGSDFSN HHHHHCCCCCCCHHH | 25.20 | 23749301 | |
| 166 | Phosphorylation | DLSNSVGSDFSNLIS HHCCCCCCCHHHHHH | 33.07 | 30377154 | |
| 169 | Phosphorylation | NSVGSDFSNLISAYE CCCCCCHHHHHHHHH | 35.40 | 30377154 | |
| 173 | Phosphorylation | SDFSNLISAYEQSSS CCHHHHHHHHHHCCC | 28.15 | 23607784 | |
| 175 | Phosphorylation | FSNLISAYEQSSSPI HHHHHHHHHHCCCCC | 14.01 | 23607784 | |
| 178 | Phosphorylation | LISAYEQSSSPIKSS HHHHHHHCCCCCCCC | 22.35 | 23607784 | |
| 179 | Phosphorylation | ISAYEQSSSPIKSSS HHHHHHCCCCCCCCC | 39.57 | 23607784 | |
| 180 | Phosphorylation | SAYEQSSSPIKSSSQ HHHHHCCCCCCCCCC | 35.57 | 23749301 | |
| 190 | Phosphorylation | KSSSQPKSSSESYID CCCCCCCCCCCCCCC | 45.86 | 22369663 | |
| 191 | Phosphorylation | SSSQPKSSSESYIDL CCCCCCCCCCCCCCC | 44.22 | 22369663 | |
| 192 | Phosphorylation | SSQPKSSSESYIDLN CCCCCCCCCCCCCCC | 37.34 | 22369663 | |
| 194 | Phosphorylation | QPKSSSESYIDLNSV CCCCCCCCCCCCCCC | 29.36 | 22369663 | |
| 195 | Phosphorylation | PKSSSESYIDLNSVR CCCCCCCCCCCCCCC | 8.39 | 22369663 | |
| 296 | Phosphorylation | DDENSSIYIAMEYMG CCCCCEEEEEEECCC | 5.65 | 28889911 | |
| 458 | Phosphorylation | PESNIIWSPSFKSFI CCCCCCCCHHHHHHH | 10.56 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MKK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MKK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MKK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-152; SER-163;SER-191; SER-192; SER-194 AND TYR-195, AND MASS SPECTROMETRY. | |
