dbPTM

MRB1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MRB1_YEAST
UniProt AC	Q06390
Protein Name	Methylated RNA-binding protein 1
Gene Name	PHO92 {ECO:0000303\|PubMed:24206186}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	306
Subcellular Localization
Protein Description	RNA-binding protein that acts as a post-transcriptional regulator of phosphate metabolism by binding to the 3'-UTR region of PHO4 mRNA, decreasing its stability. [PubMed: 24206186 Acts by recognizing and binding N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs]
Protein Sequence	MNQIWSTGPPNFYFNSEWKENKRNDRTIEDSLRELDGLIHSLERTHIEVQTNPKLKNDVTALNDINKKENKEEITHENYTHQINSIPLTSSNLNRHFSFSRDYNQSDNSNNNYYREYLSKPRYLQQSTKEQTFNEINKRKSAAIIPPWLNIPENSRFFVIKSSSLKHVKRSFYNGIWSSTHFGNKRLSEAYKKLNSGAKVFLFFSINTSGRFCGVAEMVSDLKMDLDTSIWEDEQKYGKAFKVRWVIVRDINNRSLKRFLIPSNEMKPITHSRDTQEIPYSIGISIINLFKTQDSDIFSFLDETYE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
60	Phosphorylation	PKLKNDVTALNDINK HHHCCCHHHHHHHCH		24909858

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MRB1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MRB1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MRB1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POP2_YEAST	POP2	physical	18719252
ATG17_YEAST	ATG17	physical	18719252
PHO4_YEAST	PHO4	physical	24206186
POP2_YEAST	POP2	physical	24206186
OCA1_YEAST	OCA1	genetic	27708008
PHSG_YEAST	GPH1	genetic	27708008
YAJ9_YEAST	YAR029W	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
SHG1_YEAST	SHG1	genetic	27708008
CHK1_YEAST	CHK1	genetic	27708008
YCQ6_YEAST	YCR016W	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
S2538_YEAST	YDL119C	genetic	27708008
MGMT_YEAST	MGT1	genetic	27708008
AIM11_YEAST	AIM11	genetic	27708008
HAC1_YEAST	HAC1	genetic	27708008
TFS2_YEAST	DST1	genetic	27708008
RL24B_YEAST	RPL24B	genetic	27708008
MAL12_YEAST	MAL12	genetic	27708008
GOSR1_YEAST	GOS1	genetic	27708008
YHJ5_YEAST	NEL1	genetic	27708008
STB5_YEAST	STB5	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
VHS2_YEAST	VHS2	genetic	27708008
BFA1_YEAST	BFA1	genetic	27708008
YJ90_YEAST	YJR120W	genetic	27708008
HAP4_YEAST	HAP4	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
SHB17_YEAST	SHB17	genetic	27708008
POM33_YEAST	POM33	genetic	27708008
VID22_YEAST	VID22	genetic	27708008
SAP30_YEAST	SAP30	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
PUB1_YEAST	PUB1	genetic	27708008
ODP2_YEAST	LAT1	genetic	27708008
PMS1_YEAST	PMS1	genetic	27708008
ATG3_YEAST	ATG3	genetic	27708008
MSH2_YEAST	MSH2	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
CY1_YEAST	CYT1	genetic	27708008
HAP5_YEAST	HAP5	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
UME1_YEAST	UME1	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
ARR2_YEAST	ARR2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MRB1_YEAST

Related Literatures of Post-Translational Modification