| UniProt ID | NEW1_YEAST | |
|---|---|---|
| UniProt AC | Q08972 | |
| Protein Name | [NU+] prion formation protein 1 | |
| Gene Name | NEW1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1196 | |
| Subcellular Localization | Cytoplasm . Nucleus. | |
| Protein Description | May be involved in the mRNA export process (By similarity). Forms the [NU+] prion and induces [PSI+] prion formation.. | |
| Protein Sequence | MPPKKFKDLNSFLDDQPKDPNLVASPFGGYFKNPAADAGSNNASKKSSYQQQRNWKQGGNYQQGGYQSYNSNYNNYNNYNNYNNYNNYNNYNKYNGQGYQKSTYKQSAVTPNQSGTPTPSASTTSLTSLNEKLSNLELTPISQFLSKIPECQSITDCKNQIKLIIEEFGKEGNSTGEKIEEWKIVDVLSKFIKPKNPSLVRESAMLIISNIAQFFSGKPPQEAYLLPFFNVALDCISDKENTVKRAAQHAIDSLLNCFPMEALTCFVLPTILDYLSSGAKWQAKMAALSVVDRIREDSANDLLELTFKDAVPVLTDVATDFKPELAKQGYKTLLDYVSILDNLDLSPRYKLIVDTLQDPSKVPESVKSLSSVTFVAEVTEPSLSLLVPILNRSLNLSSSSQEQLRQTVIVVENLTRLVNNRNEIESFIPLLLPGIQKVVDTASLPEVRELAEKALNVLKEDDEADKENKFSGRLTLEEGRDFLLDHLKDIKADDSCFVKPYMNDETVIKYMSKILTVDSNVNDWKRLEDFLTAVFGGSDSQREFVKQDFIHNLRALFYQEKERADEDEGIEIVNTDFSLAYGSRMLLNKTNLRLLKGHRYGLCGRNGAGKSTLMRAIANGQLDGFPDKDTLRTCFVEHKLQGEEGDLDLVSFIALDEELQSTSREEIAAALESVGFDEERRAQTVGSLSGGWKMKLELARAMLQKADILLLDEPTNHLDVSNVKWLEEYLLEHTDITSLIVSHDSGFLDTVCTDIIHYENKKLAYYKGNLAAFVEQKPEAKSYYTLTDSNAQMRFPPPGILTGVKSNTRAVAKMTDVTFSYPGAQKPSLSHVSCSLSLSSRVACLGPNGAGKSTLIKLLTGELVPNEGKVEKHPNLRIGYIAQHALQHVNEHKEKTANQYLQWRYQFGDDREVLLKESRKISEDEKEMMTKEIDIDDGRGKRAIEAIVGRQKLKKSFQYEVKWKYWKPKYNSWVPKDVLVEHGFEKLVQKFDDHEASREGLGYRELIPSVITKHFEDVGLDSEIANHTPLGSLSGGQLVKVVIAGAMWNNPHLLVLDEPTNYLDRDSLGALAVAIRDWSGGVVMISHNNEFVGALCPEQWIVENGKMVQKGSAQVDQSKFEDGGNADAVGLKASNLAKPSVDDDDSPANIKVKQRKKRLTRNEKKLQAERRRLRYIEWLSSPKGTPKPVDTDDEED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Ubiquitination | ---MPPKKFKDLNSF ---CCCHHHHCHHHH | 64.52 | 17644757 | |
| 7 | Acetylation | -MPPKKFKDLNSFLD -CCCHHHHCHHHHCC | 70.91 | 24489116 | |
| 7 | Ubiquitination | -MPPKKFKDLNSFLD -CCCHHHHCHHHHCC | 70.91 | 17644757 | |
| 11 | Phosphorylation | KKFKDLNSFLDDQPK HHHHCHHHHCCCCCC | 34.19 | 21440633 | |
| 18 | Ubiquitination | SFLDDQPKDPNLVAS HHCCCCCCCCCCCCC | 78.98 | 17644757 | |
| 25 | Phosphorylation | KDPNLVASPFGGYFK CCCCCCCCCCCCCCC | 17.18 | 21440633 | |
| 32 | Ubiquitination | SPFGGYFKNPAADAG CCCCCCCCCCCCCCC | 54.24 | 24961812 | |
| 40 | Phosphorylation | NPAADAGSNNASKKS CCCCCCCCCCCCCCC | 28.73 | 23749301 | |
| 44 | Phosphorylation | DAGSNNASKKSSYQQ CCCCCCCCCCCHHHH | 42.62 | 30377154 | |
| 45 | Acetylation | AGSNNASKKSSYQQQ CCCCCCCCCCHHHHH | 55.02 | 23572591 | |
| 48 | Phosphorylation | NNASKKSSYQQQRNW CCCCCCCHHHHHHHH | 35.52 | 28889911 | |
| 101 | Ubiquitination | YNGQGYQKSTYKQSA CCCCCCCCCEEECCC | 35.96 | 23749301 | |
| 105 | Ubiquitination | GYQKSTYKQSAVTPN CCCCCEEECCCCCCC | 37.55 | 24961812 | |
| 107 | Phosphorylation | QKSTYKQSAVTPNQS CCCEEECCCCCCCCC | 22.13 | 22369663 | |
| 110 | Phosphorylation | TYKQSAVTPNQSGTP EEECCCCCCCCCCCC | 19.08 | 22369663 | |
| 114 | Phosphorylation | SAVTPNQSGTPTPSA CCCCCCCCCCCCCCC | 51.80 | 22369663 | |
| 116 | Phosphorylation | VTPNQSGTPTPSAST CCCCCCCCCCCCCCC | 29.27 | 22369663 | |
| 118 | Phosphorylation | PNQSGTPTPSASTTS CCCCCCCCCCCCCCC | 29.70 | 25521595 | |
| 120 | Phosphorylation | QSGTPTPSASTTSLT CCCCCCCCCCCCCCH | 37.01 | 25521595 | |
| 122 | Phosphorylation | GTPTPSASTTSLTSL CCCCCCCCCCCCHHH | 36.23 | 22369663 | |
| 123 | Phosphorylation | TPTPSASTTSLTSLN CCCCCCCCCCCHHHH | 21.81 | 25521595 | |
| 124 | Phosphorylation | PTPSASTTSLTSLNE CCCCCCCCCCHHHHH | 21.17 | 20377248 | |
| 125 | Phosphorylation | TPSASTTSLTSLNEK CCCCCCCCCHHHHHH | 29.73 | 22369663 | |
| 127 | Phosphorylation | SASTTSLTSLNEKLS CCCCCCCHHHHHHHH | 30.82 | 22369663 | |
| 128 | Phosphorylation | ASTTSLTSLNEKLSN CCCCCCHHHHHHHHC | 34.19 | 22369663 | |
| 132 | Ubiquitination | SLTSLNEKLSNLELT CCHHHHHHHHCCCCC | 57.02 | 24961812 | |
| 147 | Ubiquitination | PISQFLSKIPECQSI CHHHHHHCCCCCCCH | 65.51 | 17644757 | |
| 158 | Acetylation | CQSITDCKNQIKLII CCCHHHHHHHHHHHH | 55.48 | 24489116 | |
| 158 | Ubiquitination | CQSITDCKNQIKLII CCCHHHHHHHHHHHH | 55.48 | 23749301 | |
| 170 | Acetylation | LIIEEFGKEGNSTGE HHHHHHHHCCCCCCC | 68.70 | 24489116 | |
| 178 | Acetylation | EGNSTGEKIEEWKIV CCCCCCCCHHHHHHH | 57.68 | 24489116 | |
| 183 | Acetylation | GEKIEEWKIVDVLSK CCCHHHHHHHHHHHH | 35.81 | 24489116 | |
| 190 | Acetylation | KIVDVLSKFIKPKNP HHHHHHHHHCCCCCH | 47.12 | 24489116 | |
| 193 | Acetylation | DVLSKFIKPKNPSLV HHHHHHCCCCCHHHH | 53.74 | 24489116 | |
| 195 | Acetylation | LSKFIKPKNPSLVRE HHHHCCCCCHHHHHH | 76.20 | 24489116 | |
| 289 | Phosphorylation | QAKMAALSVVDRIRE HHHHHHHHHHHHHCC | 18.50 | 24909858 | |
| 322 | Acetylation | TDVATDFKPELAKQG HHHHCCCCHHHHHCC | 40.15 | 24489116 | |
| 327 | Acetylation | DFKPELAKQGYKTLL CCCHHHHHCCHHHHH | 57.80 | 24489116 | |
| 331 | Ubiquitination | ELAKQGYKTLLDYVS HHHHCCHHHHHHHHH | 39.25 | 17644757 | |
| 350 | Acetylation | LDLSPRYKLIVDTLQ CCCCCCCEEEEECCC | 32.77 | 24489116 | |
| 350 | Ubiquitination | LDLSPRYKLIVDTLQ CCCCCCCEEEEECCC | 32.77 | 17644757 | |
| 361 | Ubiquitination | DTLQDPSKVPESVKS ECCCCHHHCCHHHHH | 68.17 | 17644757 | |
| 367 | Ubiquitination | SKVPESVKSLSSVTF HHCCHHHHHCCCEEE | 55.76 | 17644757 | |
| 441 | Phosphorylation | GIQKVVDTASLPEVR CHHHHHCCCCCHHHH | 13.41 | 21126336 | |
| 443 | Phosphorylation | QKVVDTASLPEVREL HHHHCCCCCHHHHHH | 46.69 | 25752575 | |
| 459 | Succinylation | EKALNVLKEDDEADK HHHHHHHHCCCHHHH | 55.61 | 23954790 | |
| 488 | Acetylation | DFLLDHLKDIKADDS HHHHHHHHHCCCCCC | 54.72 | 24489116 | |
| 488 | Ubiquitination | DFLLDHLKDIKADDS HHHHHHHHHCCCCCC | 54.72 | 17644757 | |
| 499 | Acetylation | ADDSCFVKPYMNDET CCCCCCCCCCCCHHH | 15.35 | 24489116 | |
| 513 | Ubiquitination | TVIKYMSKILTVDSN HHHHHHHHHEEECCC | 25.79 | 24961812 | |
| 525 | Acetylation | DSNVNDWKRLEDFLT CCCCCCHHHHHHHHH | 50.39 | 24489116 | |
| 525 | Ubiquitination | DSNVNDWKRLEDFLT CCCCCCHHHHHHHHH | 50.39 | 17644757 | |
| 546 | Acetylation | DSQREFVKQDFIHNL HHHHHHHHHHHHHHH | 49.85 | 24489116 | |
| 546 | Ubiquitination | DSQREFVKQDFIHNL HHHHHHHHHHHHHHH | 49.85 | 24961812 | |
| 628 | Acetylation | QLDGFPDKDTLRTCF CCCCCCCHHHHHHHH | 53.50 | 24489116 | |
| 628 | Ubiquitination | QLDGFPDKDTLRTCF CCCCCCCHHHHHHHH | 53.50 | 23749301 | |
| 689 | Phosphorylation | AQTVGSLSGGWKMKL HHCCCCCCCHHHHHH | 36.64 | 30377154 | |
| 693 | Acetylation | GSLSGGWKMKLELAR CCCCCHHHHHHHHHH | 29.45 | 24489116 | |
| 693 | Ubiquitination | GSLSGGWKMKLELAR CCCCCHHHHHHHHHH | 29.45 | 17644757 | |
| 705 | Ubiquitination | LARAMLQKADILLLD HHHHHHHHCCEEEEC | 44.03 | 17644757 | |
| 724 | Ubiquitination | HLDVSNVKWLEEYLL CCCHHHCHHHHHHHH | 50.76 | 17644757 | |
| 729 | Phosphorylation | NVKWLEEYLLEHTDI HCHHHHHHHHHCCCC | 13.76 | 21551504 | |
| 737 | Phosphorylation | LLEHTDITSLIVSHD HHHCCCCCEEEECCC | 21.93 | 21551504 | |
| 738 | Phosphorylation | LEHTDITSLIVSHDS HHCCCCCEEEECCCC | 19.21 | 21551504 | |
| 745 | Phosphorylation | SLIVSHDSGFLDTVC EEEECCCCCCCCCCH | 26.48 | 21551504 | |
| 767 | Ubiquitination | NKKLAYYKGNLAAFV CCEEEEEECCHHHHH | 28.75 | 17644757 | |
| 777 | Acetylation | LAAFVEQKPEAKSYY HHHHHHCCCCCCCEE | 31.18 | 24489116 | |
| 777 | Ubiquitination | LAAFVEQKPEAKSYY HHHHHHCCCCCCCEE | 31.18 | 17644757 | |
| 781 | Acetylation | VEQKPEAKSYYTLTD HHCCCCCCCEEEECC | 37.01 | 24489116 | |
| 781 | Ubiquitination | VEQKPEAKSYYTLTD HHCCCCCCCEEEECC | 37.01 | 17644757 | |
| 821 | Phosphorylation | MTDVTFSYPGAQKPS CEECEEECCCCCCCC | 11.07 | 27017623 | |
| 857 | Acetylation | AGKSTLIKLLTGELV CCHHHHHHHHHCCCC | 40.32 | 24489116 | |
| 857 | Ubiquitination | AGKSTLIKLLTGELV CCHHHHHHHHHCCCC | 40.32 | 17644757 | |
| 869 | Acetylation | ELVPNEGKVEKHPNL CCCCCCCCCCCCCCC | 40.83 | 24489116 | |
| 869 | Ubiquitination | ELVPNEGKVEKHPNL CCCCCCCCCCCCCCC | 40.83 | 17644757 | |
| 872 | Acetylation | PNEGKVEKHPNLRIG CCCCCCCCCCCCCHH | 68.31 | 24489116 | |
| 872 | Ubiquitination | PNEGKVEKHPNLRIG CCCCCCCCCCCCCHH | 68.31 | 17644757 | |
| 893 | Ubiquitination | LQHVNEHKEKTANQY HHHHHHCHHHHHHHH | 55.52 | 17644757 | |
| 895 | Ubiquitination | HVNEHKEKTANQYLQ HHHHCHHHHHHHHHH | 58.71 | 17644757 | |
| 916 | Acetylation | DDREVLLKESRKISE CCHHHHHHHHHCCCH | 49.86 | 24489116 | |
| 962 | Acetylation | KSFQYEVKWKYWKPK HHCCEEEECCCCCCC | 26.48 | 24489116 | |
| 969 | Acetylation | KWKYWKPKYNSWVPK ECCCCCCCCCCCCCH | 54.02 | 24489116 | |
| 976 | Acetylation | KYNSWVPKDVLVEHG CCCCCCCHHHHHHCC | 51.34 | 24489116 | |
| 986 | Acetylation | LVEHGFEKLVQKFDD HHHCCHHHHHHHHCC | 52.26 | 24489116 | |
| 986 | Ubiquitination | LVEHGFEKLVQKFDD HHHCCHHHHHHHHCC | 52.26 | 17644757 | |
| 990 | Acetylation | GFEKLVQKFDDHEAS CHHHHHHHHCCHHHH | 43.19 | 24489116 | |
| 990 | Ubiquitination | GFEKLVQKFDDHEAS CHHHHHHHHCCHHHH | 43.19 | 17644757 | |
| 1013 | Ubiquitination | LIPSVITKHFEDVGL HHHHHHHHHHHHCCC | 34.86 | 17644757 | |
| 1040 | Ubiquitination | LSGGQLVKVVIAGAM CCCCCEEEEEEECHH | 39.10 | 17644757 | |
| 1110 | Ubiquitination | ENGKMVQKGSAQVDQ ECCEEEECCCCCCCH | 43.34 | 17644757 | |
| 1119 | Acetylation | SAQVDQSKFEDGGNA CCCCCHHHCCCCCCC | 47.33 | 24489116 | |
| 1119 | Ubiquitination | SAQVDQSKFEDGGNA CCCCCHHHCCCCCCC | 47.33 | 23749301 | |
| 1132 | Ubiquitination | NADAVGLKASNLAKP CCCHHHEEHHHCCCC | 43.79 | 17644757 | |
| 1138 | Acetylation | LKASNLAKPSVDDDD EEHHHCCCCCCCCCC | 40.78 | 24489116 | |
| 1138 | Ubiquitination | LKASNLAKPSVDDDD EEHHHCCCCCCCCCC | 40.78 | 23749301 | |
| 1140 | Phosphorylation | ASNLAKPSVDDDDSP HHHCCCCCCCCCCCC | 37.16 | 21440633 | |
| 1146 | Phosphorylation | PSVDDDDSPANIKVK CCCCCCCCCCCHHHH | 32.67 | 20377248 | |
| 1151 | Acetylation | DDSPANIKVKQRKKR CCCCCCHHHHHHHHH | 43.09 | 24489116 | |
| 1151 | Ubiquitination | DDSPANIKVKQRKKR CCCCCCHHHHHHHHH | 43.09 | 15699485 | |
| 1180 | Phosphorylation | LRYIEWLSSPKGTPK HHHHHHHCCCCCCCC | 45.74 | 22369663 | |
| 1181 | Phosphorylation | RYIEWLSSPKGTPKP HHHHHHCCCCCCCCC | 28.58 | 22369663 | |
| 1183 | Ubiquitination | IEWLSSPKGTPKPVD HHHHCCCCCCCCCCC | 76.88 | 23749301 | |
| 1185 | Phosphorylation | WLSSPKGTPKPVDTD HHCCCCCCCCCCCCC | 33.98 | 22890988 | |
| 1191 | Phosphorylation | GTPKPVDTDDEED-- CCCCCCCCCCCCC-- | 45.65 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEW1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEW1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEW1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; THR-123; SER-125;SER-443 AND THR-1191, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; SER-125 ANDTHR-1191, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1191, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1191, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1191, AND MASSSPECTROMETRY. | |
