DBP3_YEAST - dbPTM
DBP3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DBP3_YEAST
UniProt AC P20447
Protein Name ATP-dependent RNA helicase DBP3
Gene Name DBP3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs..
Protein Sequence MTKEEIADKKRKVVDEEVIEKKKSKKHKKDKKDKKEKKDKKHKKHKKEKKGEKEVEVPEKESEKKPEPTSAVASEFYVQSEALTSLPQSDIDEYFKENEIAVEDSLDLALRPLLSFDYLSLDSSIQAEISKFPKPTPIQAVAWPYLLSGKDVVGVAETGSGKTFAFGVPAISHLMNDQKKRGIQVLVISPTRELASQIYDNLIVLTDKVGMQCCCVYGGVPKDEQRIQLKKSQVVVATPGRLLDLLQEGSVDLSQVNYLVLDEADRMLEKGFEEDIKNIIRETDASKRQTLMFTATWPKEVRELASTFMNNPIKVSIGNTDQLTANKRITQIVEVVDPRGKERKLLELLKKYHSGPKKNEKVLIFALYKKEAARVERNLKYNGYNVAAIHGDLSQQQRTQALNEFKSGKSNLLLATDVAARGLDIPNVKTVINLTFPLTVEDYVHRIGRTGRAGQTGTAHTLFTEQEKHLAGGLVNVLNGANQPVPEDLIKFGTHTKKKEHSAYGSFFKDVDLTKKPKKITFD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21AcetylationVDEEVIEKKKSKKHK
CCHHHHHHHHHHHCC		55.1425381059
89PhosphorylationALTSLPQSDIDEYFK
HHHCCCHHHHHHHHH		34.3021440633
162UbiquitinationVAETGSGKTFAFGVP
EEECCCCCEEECCHH		42.0117644757
179UbiquitinationSHLMNDQKKRGIQVL
HHHHCCCHHCCCEEE		47.5017644757
180UbiquitinationHLMNDQKKRGIQVLV
HHHCCCHHCCCEEEE		50.6617644757
208UbiquitinationNLIVLTDKVGMQCCC
CCEEEECCCCCEEEE		35.1417644757
232PhosphorylationQRIQLKKSQVVVATP
HHEECCCCCEEEECC		26.9821440633
238PhosphorylationKSQVVVATPGRLLDL
CCCEEEECCCHHHHH		18.0519779198
270AcetylationEADRMLEKGFEEDIK
HHHHHHHCCCHHHHH		66.0124489116
277AcetylationKGFEEDIKNIIRETD
CCCHHHHHHHHHHCC		55.1824489116
296PhosphorylationQTLMFTATWPKEVRE
CEEEEEECCCHHHHH		38.9630377154
350AcetylationRKLLELLKKYHSGPK
HHHHHHHHHHCCCCC		65.0024489116
380AcetylationARVERNLKYNGYNVA
HHHHHHHHCCCCCEE		39.9724489116
381PhosphorylationRVERNLKYNGYNVAA
HHHHHHHCCCCCEEE		19.5829136822
384PhosphorylationRNLKYNGYNVAAIHG
HHHHCCCCCEEEEEE		11.6529136822
407PhosphorylationQALNEFKSGKSNLLL
HHHHHHHCCCCCEEE		57.6930377154
409AcetylationLNEFKSGKSNLLLAT
HHHHHCCCCCEEEEE		43.1724489116
429UbiquitinationGLDIPNVKTVINLTF
CCCCCCCCEEEEEEC		43.6517644757
468UbiquitinationTLFTEQEKHLAGGLV
ECCCHHHHHHHHHHH		43.5417644757
491AcetylationPVPEDLIKFGTHTKK
CCCHHHHHHCCCCCC		45.0724489116
502PhosphorylationHTKKKEHSAYGSFFK
CCCCCCCCCCCCCCC		25.0330377154
506PhosphorylationKEHSAYGSFFKDVDL
CCCCCCCCCCCCCCC		18.1621440633
509AcetylationSAYGSFFKDVDLTKK
CCCCCCCCCCCCCCC		55.6324489116
515AcetylationFKDVDLTKKPKKITF
CCCCCCCCCCCCCCC		74.5025381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DBP3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DBP3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DBP3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BMH1_YEASTBMH1physical
14759368
DBP3_YEASTDBP3physical
14759368
NSR1_YEASTNSR1physical
14759368
CBF5_YEASTCBF5physical
14759368
GAR1_YEASTGAR1physical
14759368
NHP2_YEASTNHP2physical
14759368
NOP56_YEASTNOP56physical
14759368
FBRL_YEASTNOP1physical
14759368
KRR1_YEASTKRR1physical
16554755
FBRL_YEASTNOP1physical
16554755
NHP2_YEASTNHP2physical
16554755
SNU13_YEASTSNU13physical
16554755
NOP10_YEASTNOP10physical
16554755
GAR1_YEASTGAR1physical
16554755
CBF5_YEASTCBF5physical
16554755
NOP56_YEASTNOP56physical
16554755
KRI1_YEASTKRI1physical
16554755
MAK5_YEASTMAK5physical
16449635
DBP7_YEASTDBP7genetic
16449635
PWP1_YEASTPWP1physical
18467557
GAR1_YEASTGAR1physical
18467557
RRP8_YEASTRRP8genetic
19061648
EIF3J_YEASTHCR1genetic
19061648
IF2A_YEASTSUI2genetic
19061648
LTV1_YEASTLTV1genetic
19061648
BUD21_YEASTBUD21genetic
19061648
SFT2_YEASTSFT2genetic
20093466
HMT1_YEASTHMT1genetic
20093466
REI1_YEASTREI1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
UBP1_YEASTUBP1genetic
20093466
RMD1_YEASTRMD1genetic
20093466
RRP8_YEASTRRP8genetic
20093466
ODO2_YEASTKGD2genetic
20093466
BST1_YEASTBST1genetic
20093466
RMD8_YEASTRMD8genetic
20093466
RL8A_YEASTRPL8Agenetic
20093466
SSF1_YEASTSSF1genetic
20093466
I23O_YEASTBNA2genetic
20093466
YJ90_YEASTYJR120Wgenetic
20093466
GBLP_YEASTASC1genetic
20093466
REXO4_YEASTREX4genetic
20093466
NOP12_YEASTNOP12genetic
20093466
NEW1_YEASTNEW1genetic
20093466
OYE3_YEASTOYE3genetic
20093466
PMA2_YEASTPMA2genetic
20093466
SRS2_YEASTSRS2genetic
21459050
TCPZ_YEASTCCT6genetic
27708008
ACT_YEASTACT1genetic
27708008
BUB1_YEASTBUB1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
SDS3_YEASTSDS3genetic
27708008
MAK16_YEASTMAK16genetic
27708008
MAK5_YEASTMAK5genetic
27708008
FBRL_YEASTNOP1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
CDC1_YEASTCDC1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
DAM1_YEASTDAM1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
RRP4_YEASTRRP4genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
EXO70_YEASTEXO70genetic
27708008
RFC2_YEASTRFC2genetic
27708008
NOP56_YEASTNOP56genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DBP9_YEASTDBP9genetic
27708008
LIP1_YEASTLIP1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
BRX1_YEASTBRX1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
ATG8_YEASTATG8genetic
27708008
H4_YEASTHHF1genetic
27708008
HMT1_YEASTHMT1genetic
27708008
REI1_YEASTREI1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
RRP8_YEASTRRP8genetic
27708008
NUM1_YEASTNUM1genetic
27708008
BMH1_YEASTBMH1genetic
27708008
RMD8_YEASTRMD8genetic
27708008
PIH1_YEASTPIH1genetic
27708008
SSF1_YEASTSSF1genetic
27708008
LRP1_YEASTLRP1genetic
27708008
ARP1_YEASTARP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
VPS35_YEASTVPS35genetic
27708008
LDB18_YEASTLDB18genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
SIC1_YEASTSIC1genetic
27708008
RSA3_YEASTRSA3genetic
27708008
GBLP_YEASTASC1genetic
27708008
NOP12_YEASTNOP12genetic
27708008
REXO4_YEASTREX4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
PMA2_YEASTPMA2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DBP3_YEAST

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Related Literatures of Post-Translational Modification

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