NOP10_YEAST - dbPTM
NOP10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOP10_YEAST
UniProt AC Q6Q547
Protein Name H/ACA ribonucleoprotein complex subunit NOP10
Gene Name NOP10
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 58
Subcellular Localization Nucleus, nucleolus .
Protein Description Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. [PubMed: 9843512 This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1]
Protein Sequence MHLMYTLGPDGKRIYTLKKVTESGEITKSAHPARFSPDDKYSRQRVTLKKRFGLVPGQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12AcetylationYTLGPDGKRIYTLKK
EEECCCCCEEEEEEE		42.9025381059
21PhosphorylationIYTLKKVTESGEITK
EEEEEEEECCCCCCC		33.0621082442
23PhosphorylationTLKKVTESGEITKSA
EEEEEECCCCCCCCC		32.1528889911
27PhosphorylationVTESGEITKSAHPAR
EECCCCCCCCCCCCC		18.0428889911
28UbiquitinationTESGEITKSAHPARF
ECCCCCCCCCCCCCC		51.8423749301
28AcetylationTESGEITKSAHPARF
ECCCCCCCCCCCCCC		51.8425381059
36PhosphorylationSAHPARFSPDDKYSR
CCCCCCCCCCCCCCC		23.1317287358
40AcetylationARFSPDDKYSRQRVT
CCCCCCCCCCCCEEE		53.1322865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOP10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOP10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOP10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBP2_YEASTDBP2physical
18467557
RPA34_YEASTRPA34physical
18467557
GAR1_YEASTGAR1physical
18467557
NAF1_YEASTNAF1physical
18719252
RKM1_YEASTRKM1physical
18719252
NHP2_YEASTNHP2physical
18719252
CDC1_YEASTCDC1genetic
27708008
COG3_YEASTCOG3genetic
27708008
FDFT_YEASTERG9genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
TIM22_YEASTTIM22genetic
27708008
SNU56_YEASTSNU56genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
PRS8_YEASTRPT6genetic
27708008
SLD3_YEASTSLD3genetic
27708008
PGTB1_YEASTCDC43genetic
27708008
SMD1_YEASTSMD1genetic
27708008
DAM1_YEASTDAM1genetic
27708008
YIP1_YEASTYIP1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
SMC3_YEASTSMC3genetic
27708008
MED14_YEASTRGR1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
SC61A_YEASTSEC61genetic
27708008
VTI1_YEASTVTI1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
LST8_YEASTLST8genetic
27708008
PROF_YEASTPFY1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
MYO2_YEASTMYO2genetic
27708008
HRR25_YEASTHRR25genetic
27708008
SEC23_YEASTSEC23genetic
27708008
ATC3_YEASTDRS2genetic
27708008
GEM1_YEASTGEM1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SHG1_YEASTSHG1genetic
27708008
DCC1_YEASTDCC1genetic
27708008
STE50_YEASTSTE50genetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
TGL2_YEASTTGL2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
MNN10_YEASTMNN10genetic
27708008
MRX8_YEASTYDR336Wgenetic
27708008
AIM11_YEASTAIM11genetic
27708008
BEM2_YEASTBEM2genetic
27708008
MIC19_YEASTMIC19genetic
27708008
ATC1_YEASTPMR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
MDM34_YEASTMDM34genetic
27708008
PHB1_YEASTPHB1genetic
27708008
QCR9_YEASTQCR9genetic
27708008
ELP2_YEASTELP2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ICE2_YEASTICE2genetic
27708008
GSH1_YEASTGSH1genetic
27708008
PHO86_YEASTPHO86genetic
27708008
ELM1_YEASTELM1genetic
27708008
KTI12_YEASTKTI12genetic
27708008
PEX1_YEASTPEX1genetic
27708008
MIC60_YEASTMIC60genetic
27708008
SRN2_YEASTSRN2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
COA4_YEASTCOA4genetic
27708008
ROM2_YEASTROM2genetic
27708008
RM39_YEASTMRPL39genetic
27708008
TSA1_YEASTTSA1genetic
27708008
SAP30_YEASTSAP30genetic
27708008
NGL2_YEASTNGL2genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
PT127_YEASTPET127genetic
27708008
HST3_YEASTHST3genetic
27708008
LIPA_YEASTLIP5genetic
27708008
PALA_YEASTRIM20genetic
27708008
MSC6_YEASTMSC6genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
COX10_YEASTCOX10genetic
27708008
CTF4_YEASTCTF4genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOP10_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY.

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