| UniProt ID | MDM34_YEAST | |
|---|---|---|
| UniProt AC | P53083 | |
| Protein Name | Mitochondrial distribution and morphology protein 34 {ECO:0000255|HAMAP-Rule:MF_03105} | |
| Gene Name | MDM34 {ECO:0000255|HAMAP-Rule:MF_03105} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 459 | |
| Subcellular Localization |
Mitochondrion outer membrane Multi-pass membrane protein . The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nuc |
|
| Protein Description | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. [PubMed: 11907266] | |
| Protein Sequence | MSFRFNEAVFGDNSFNERIREKLSTALNSPSKKKLDILKSGIKVQKVDFPTIPQLEILDLDIITQPKSLAKGICKISCKDAMLRIQTVIESNLLLINEQDTPSFTMPQLINNGSFTIPITMTFSSIELEAITNIFVKNPGIGISFNDVDLDFKFDCSVKILQSTIERRLKESMHVVFKDVLPSLIFNTSQNWFTNRGESTSTIPGKREHHHQQTTMSRNVILDGSDFQELSPINMLRLSSIVSSRSTLSLHSTVMNSLSAIPGCLERQNLYRFISRMPSLNNYYSSQSFPQPKSSTVSSKQLVKPFYCSHNLLPKTVLDSSQYDLATITKIQSRLFDRSNSNDDNAKPRRRKIKCKKTRTPSNLQSQGEQAVDDSTAIETVTSTPVQTPIPELEEQSPPYLKTTVSIRDKYVIPEKISLNLDSKKDTSKKKPFYFIGLNSQEPSNNWKWGMEDSPPPYH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Ubiquitination | FNERIREKLSTALNS HHHHHHHHHHHHHCC | 37.58 | 17644757 | |
| 24 | Phosphorylation | ERIREKLSTALNSPS HHHHHHHHHHHCCCC | 23.78 | 29688323 | |
| 25 | Phosphorylation | RIREKLSTALNSPSK HHHHHHHHHHCCCCH | 45.67 | 29688323 | |
| 29 | Phosphorylation | KLSTALNSPSKKKLD HHHHHHCCCCHHHHH | 31.25 | 21440633 | |
| 31 | Phosphorylation | STALNSPSKKKLDIL HHHHCCCCHHHHHHH | 57.86 | 27017623 | |
| 32 | Ubiquitination | TALNSPSKKKLDILK HHHCCCCHHHHHHHH | 58.26 | 17644757 | |
| 33 | Ubiquitination | ALNSPSKKKLDILKS HHCCCCHHHHHHHHC | 64.01 | 17644757 | |
| 34 | Ubiquitination | LNSPSKKKLDILKSG HCCCCHHHHHHHHCC | 55.94 | 17644757 | |
| 43 | Ubiquitination | DILKSGIKVQKVDFP HHHHCCCEEEECCCC | 41.98 | 17644757 | |
| 46 | Ubiquitination | KSGIKVQKVDFPTIP HCCCEEEECCCCCCC | 46.92 | 17644757 | |
| 67 | Ubiquitination | LDIITQPKSLAKGIC CEEECCCHHHCCCCC | 48.56 | 17644757 | |
| 293 | Ubiquitination | SQSFPQPKSSTVSSK CCCCCCCCCCCCCHH | 52.36 | 23749301 | |
| 300 | Ubiquitination | KSSTVSSKQLVKPFY CCCCCCHHHCCCCEE | 39.90 | 23749301 | |
| 304 | Ubiquitination | VSSKQLVKPFYCSHN CCHHHCCCCEECCCC | 37.69 | 23749301 | |
| 315 | Ubiquitination | CSHNLLPKTVLDSSQ CCCCCCCCHHCCCCC | 51.76 | 17644757 | |
| 321 | Phosphorylation | PKTVLDSSQYDLATI CCHHCCCCCCCHHHH | 32.21 | 27214570 | |
| 330 | Ubiquitination | YDLATITKIQSRLFD CCHHHHHHHHHHHHC | 34.59 | 23749301 | |
| 333 | Phosphorylation | ATITKIQSRLFDRSN HHHHHHHHHHHCCCC | 34.13 | 21440633 | |
| 339 | Phosphorylation | QSRLFDRSNSNDDNA HHHHHCCCCCCCCCC | 46.59 | 19823750 | |
| 341 | Phosphorylation | RLFDRSNSNDDNAKP HHHCCCCCCCCCCCC | 42.77 | 21440633 | |
| 347 | Ubiquitination | NSNDDNAKPRRRKIK CCCCCCCCCCHHCCC | 45.36 | 17644757 | |
| 384 | Phosphorylation | AIETVTSTPVQTPIP CEEEECCCCCCCCCC | 20.36 | 27214570 | |
| 388 | Phosphorylation | VTSTPVQTPIPELEE ECCCCCCCCCCCHHH | 24.34 | 23749301 | |
| 410 | Ubiquitination | TTVSIRDKYVIPEKI EEEEECCCEECCCEE | 31.41 | 23749301 | |
| 416 | Ubiquitination | DKYVIPEKISLNLDS CCEECCCEEEECCCC | 32.04 | 23749301 | |
| 424 | Ubiquitination | ISLNLDSKKDTSKKK EEECCCCCCCCCCCC | 55.10 | 23749301 | |
| 425 | Ubiquitination | SLNLDSKKDTSKKKP EECCCCCCCCCCCCC | 70.91 | 22817900 | |
| 428 | Phosphorylation | LDSKKDTSKKKPFYF CCCCCCCCCCCCEEE | 53.24 | 28889911 | |
| 429 | Ubiquitination | DSKKDTSKKKPFYFI CCCCCCCCCCCEEEE | 67.90 | 22817900 | |
| 430 | Ubiquitination | SKKDTSKKKPFYFIG CCCCCCCCCCEEEEE | 66.50 | 23749301 | |
| 431 | Ubiquitination | KKDTSKKKPFYFIGL CCCCCCCCCEEEEEC | 44.06 | 23749301 | |
| 448 | Ubiquitination | QEPSNNWKWGMEDSP CCCCCCCCCCCCCCC | 35.67 | 23749301 | |
| 454 | Phosphorylation | WKWGMEDSPPPYH-- CCCCCCCCCCCCC-- | 26.46 | 21440633 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MDM34_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MDM34_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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