LAC1_YEAST - dbPTM
LAC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAC1_YEAST
UniProt AC P28496
Protein Name Sphingosine N-acyltransferase LAC1
Gene Name LAC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 418
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins..
Protein Sequence MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSTIKPSPS
------CCCCCCCCC		38.5522814378
7Phosphorylation-MSTIKPSPSNNNLK
-CCCCCCCCCCCCCC		35.6422369663
9PhosphorylationSTIKPSPSNNNLKVR
CCCCCCCCCCCCCCC		57.4322369663
23PhosphorylationRSRPRRKSSIGKIDL
CCCCCCCCCCCCCCC		25.9419684113
24PhosphorylationSRPRRKSSIGKIDLG
CCCCCCCCCCCCCCC		38.0925752575
33PhosphorylationGKIDLGDTVPSLGTM
CCCCCCCCCCCCCHH		32.3021440633
36PhosphorylationDLGDTVPSLGTMFET
CCCCCCCCCCHHCCC		34.7919823750
39PhosphorylationDTVPSLGTMFETKES
CCCCCCCHHCCCHHH		24.7919823750
43PhosphorylationSLGTMFETKESKTAA
CCCHHCCCHHHHHHH		28.9319823750
44AcetylationLGTMFETKESKTAAK
CCHHCCCHHHHHHHH		53.4424489116
46PhosphorylationTMFETKESKTAAKRR
HHCCCHHHHHHHHHH		36.5427017623
74PhosphorylationLVKKIWFSFREISYR
HHHHHHHHHHHHHHH		14.3827017623
79PhosphorylationWFSFREISYRHAWIA
HHHHHHHHHHHHHHH		16.0327017623
103N-linked_GlycosylationSAYFTSGNTTKTNVL
HHHHCCCCCCCCCEE		44.32-
182PhosphorylationEQMYAIFYTGVSGPF
HHHHHHHHHCCCCCC		9.1130377154
183PhosphorylationQMYAIFYTGVSGPFG
HHHHHHHHCCCCCCE		21.9930377154
192PhosphorylationVSGPFGIYCMYHSDL
CCCCCEEEEEECCCE		3.2930377154
197PhosphorylationGIYCMYHSDLWFFNT
EEEEEECCCEEEEEC		19.5330377154
279PhosphorylationTKMGLPIYITMDVSD
HHCCCCEEEEEEHHH		6.6028132839
393PhosphorylationGILKDDRSDSESDEE
HHHCCCCCCCCCCCC		53.1122369663
395PhosphorylationLKDDRSDSESDEESD
HCCCCCCCCCCCCCC		40.0022369663
397PhosphorylationDDRSDSESDEESDES
CCCCCCCCCCCCCCC		55.0322369663
401PhosphorylationDSESDEESDESSTTP
CCCCCCCCCCCCCCC		44.6322369663
404PhosphorylationSDEESDESSTTPTDS
CCCCCCCCCCCCCCC		37.6722369663
407PhosphorylationESDESSTTPTDSTPT
CCCCCCCCCCCCCCC		26.5819779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIP1_YEASTLIP1physical
11283351
YPC1_YEASTYPC1genetic
11694577
YDC1_YEASTYDC1genetic
11694577
LIP1_YEASTLIP1physical
15692566
LAG1_YEASTLAG1physical
15692566
LAG1_YEASTLAG1genetic
16269340
SUR2_YEASTSUR2genetic
16269340
YET1_YEASTYET1genetic
16269340
PFD2_YEASTGIM4genetic
16269340
ALG5_YEASTALG5physical
18467557
LAC1_YEASTLAC1physical
18467557
GST1_YEASTGTT1physical
18719252
HCM1_YEASTHCM1genetic
20093466
PAT1_YEASTPAT1genetic
20093466
ASK10_YEASTASK10genetic
20093466
COG6_YEASTCOG6genetic
20093466
CSK22_YEASTCKA2genetic
20093466
SKI7_YEASTSKI7genetic
20093466
LAG1_YEASTLAG1physical
16093310
MKAR_YEASTIFA38physical
16093310
SNL1_YEASTSNL1physical
16093310
YET1_YEASTYET1physical
16093310
ELO3_YEASTELO3physical
16093310
NDOR1_YEASTTAH18physical
16093310
LAC1_YEASTLAC1physical
16093310
SAC1_YEASTSAC1genetic
20526336
LAG1_YEASTLAG1genetic
20526336
ELO3_YEASTELO3genetic
20526336
SUR2_YEASTSUR2genetic
20526336
YPC1_YEASTYPC1genetic
21173150
YDC1_YEASTYDC1genetic
21173150
PLSC_YEASTSLC1genetic
21173150
DOP1_YEASTDOP1genetic
21987634
LAG1_YEASTLAG1genetic
21987634
BCH2_YEASTBCH2genetic
21987634
ELO3_YEASTELO3genetic
21987634
CYK2_YEASTHOF1genetic
21987634
ELO3_YEASTELO3genetic
23891562
LAG1_YEASTLAG1genetic
23620586
KU70_YEASTYKU70genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
CSK22_YEASTCKA2genetic
27708008
SKI7_YEASTSKI7genetic
27708008
KASH5_HUMANCCDC155physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAC1_YEAST

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Related Literatures of Post-Translational Modification

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