| UniProt ID | CSK2B_YEAST | |
|---|---|---|
| UniProt AC | P43639 | |
| Protein Name | Casein kinase II subunit beta | |
| Gene Name | CKB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 278 | |
| Subcellular Localization | ||
| Protein Description | Plays a complex role in regulating the basal catalytic activity of the alpha subunit.. | |
| Protein Sequence | MSQEFVEDYSRTGSSDDEDSGAYDEWIPSFCSRFGHEYFCQVPTEFIEDDFNMTSLSQEVPHYRKALDLILDLEAMSDEEEDEDDVVEEDEVDQEMQSNDGHDEGKRRNKSPVVNKSIIEHAAEQLYGLIHARFILTKPGLQAMAEKFDHKEFGTCPRYYCNGMQLLPCGLSDTVGKHTVRLYCPSCQDLYLPQSSRFLCLEGAFWGTSFPGVFLKHFKELEEYVERKSKESYELKVFGFRINDEAVSGPRMKWLRQYPSTEEDWEEFAKCEFETPAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSQEFVEDY ------CCHHHHHHH | 38.12 | 22369663 | |
| 2 | Acetylation | ------MSQEFVEDY ------CCHHHHHHH | 38.12 | 22814378 | |
| 10 | Phosphorylation | QEFVEDYSRTGSSDD HHHHHHHHCCCCCCC | 35.37 | 22369663 | |
| 12 | Phosphorylation | FVEDYSRTGSSDDED HHHHHHCCCCCCCCC | 35.16 | 19795423 | |
| 14 | Phosphorylation | EDYSRTGSSDDEDSG HHHHCCCCCCCCCCC | 29.95 | 19795423 | |
| 15 | Phosphorylation | DYSRTGSSDDEDSGA HHHCCCCCCCCCCCC | 50.88 | 19795423 | |
| 20 | Phosphorylation | GSSDDEDSGAYDEWI CCCCCCCCCCCHHHH | 24.23 | 19795423 | |
| 23 | Phosphorylation | DDEDSGAYDEWIPSF CCCCCCCCHHHHHHH | 20.23 | 19795423 | |
| 29 | Phosphorylation | AYDEWIPSFCSRFGH CCHHHHHHHHHHHCC | 29.74 | 19795423 | |
| 32 | Phosphorylation | EWIPSFCSRFGHEYF HHHHHHHHHHCCCEE | 28.74 | 19795423 | |
| 77 | Phosphorylation | ILDLEAMSDEEEDED HHHHHHCCCCCCCCC | 49.25 | 19795423 | |
| 98 | Phosphorylation | EVDQEMQSNDGHDEG HHHHHHHHCCCCCCC | 35.26 | 19795423 | |
| 110 | Ubiquitination | DEGKRRNKSPVVNKS CCCCCCCCCCCCCHH | 55.09 | 19722269 | |
| 111 | Phosphorylation | EGKRRNKSPVVNKSI CCCCCCCCCCCCHHH | 26.86 | 21082442 | |
| 116 | Ubiquitination | NKSPVVNKSIIEHAA CCCCCCCHHHHHHHH | 31.27 | 19722269 | |
| 138 | Ubiquitination | HARFILTKPGLQAMA HHHHHCCCHHHHHHH | 33.37 | 23749301 | |
| 138 | Acetylation | HARFILTKPGLQAMA HHHHHCCCHHHHHHH | 33.37 | 24489116 | |
| 260 | Phosphorylation | KWLRQYPSTEEDWEE HHHHHCCCCHHHHHH | 43.44 | 22369663 | |
| 261 | Phosphorylation | WLRQYPSTEEDWEEF HHHHCCCCHHHHHHH | 38.60 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CSK2B_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSK2B_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSK2B_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY. | |
