| UniProt ID | SEN1_YEAST | |
|---|---|---|
| UniProt AC | Q00416 | |
| Protein Name | Helicase SEN1 | |
| Gene Name | SEN1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2231 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.. | |
| Protein Sequence | MNSNNPDNNNSNNINNNNKDKDIAPNSDVQLATVYTKAKSYIPQIEQVYQGTNPNIQEAKLLGELLQVLAEVPKGTHLFCDPILEPISIFSLTIFSFNEEATATWLKNHFNPILSVCDKCILNFARGKCKMLQHFAIQRHVPHEHVAKFNDIVCQWRVEAVFPILRNISVNDNTGINITNEIETAMYECLCNPHMLRLNKQLKATFEAIFKFFYDTKHRLLDVTNPLSIKTFISGVIFCWCEGSKEENEWSRAFLKDLYSRNFHINLSNLTPDIIEEVYIHILFLQNPANWTEIVVSQFWSRLLPVFNLFDKDVFIEYFQVPKNVESLKKTFKFPLEPIFKMWYNHLSKSYHDKPLDFLLRGLTMFLNKFGSEFWSKIEPFTFHSILDIIFNRDSFPIKLIKIQDNPIVEHQTEVYFQLTGSVTDLLSWTLPFYHALSPSKRIQMVRKVSMAFLRIIANYPSLKSIPKACLMNSATALLRAVLTIKENERAMLYKNDEFETVLLTKTDSRALLNNPLIQDIIIRSASNPNDFYPGLGAASASVATSTMMVLAECIDFDILLLCHRTFKLYSGKPISEIPISTNVLENVTNKIDLRSFHDGPLLAKQLLVSLKNINGLLIVPSNTAVAEAHNALNQKFLLLSTRLMEKFADILPGQLSKILADEDASQGFWSCIFSSDKHLYQAATNILYNTFDVEGRLEGILAILNSNLTVNLKNINVMLQRLINCEFYEPCPRAVRVLMDVVSAFVDPISGVFANFQTLKSQNTEKEFLKFWESCWLFLDTIYKFTLKWASKYDYSELENFTKDTLDLSRSLVDSFREFSDILHDQTKNLLLNVLETFKNMLYWLRLSDEVLLESCVRLIISTSDLAHEKHVKVDDSLVEMMAKYASKAKRFSNKLTEQQASEILQKAKIFNKALTEEVATEAENYRKEKELSRLGKVIDLTDSVPASPSLSPSLSSTIASSSAESRADYLQRKALSSSITGRPRVAQPKITSFGTFQSSANAKLHRTKPVKPLSKMELARMQLLNNRVVHPPSAPAFHTKSRGLSNKNDDSSSEESDNDIESARELFAIAKAKGKGIQTVDINGKVVKRQTAAELAKQELEHMRKRLNVDMNPLYEIILQWDYTRNSEYPDDEPIGNYSDVKDFFNSPADYQKVMKPLLLLESWQGLCSSRDREDYKPFSIIVGNRTAVSDFYDVYASVAKQVIQDCGISESDLIVMAYLPDFRPDKRLSSDDFKKAQHTCLAKVRTLKNTKGGNVDVTLRIHRNHSFSKFLTLRSEIYCVKVMQMTTIEREYSTLEGLEYYDLVGQILQAKPSPPVNVDAAEIETVKKSYKLNTSQAEAIVNSVSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSSNVIKVPLEKNSSNTEQLLKKQKILICAPSNAAVDEICLRLKSGVYDKQGHQFKPQLVRVGRSDVVNVAIKDLTLEELVDKRIGERNYEIRTDPELERKFNNAVTKRRELRGKLDSESGNPESPMSTEDISKLQLKIRELSKIINELGRDRDEMREKNSVNYRNRDLDRRNAQAHILAVSDIICSTLSGSAHDVLATMGIKFDTVIIDEACQCTELSSIIPLRYGGKRCIMVGDPNQLPPTVLSGAASNFKYNQSLFVRMEKNSSPYLLDVQYRMHPSISKFPSSEFYQGRLKDGPGMDILNKRPWHQLEPLAPYKFFDIISGRQEQNAKTMSYTNMEEIRVAIELVDYLFRKFDNKIDFTGKIGIISPYREQMQKMRKEFARYFGGMINKSIDFNTIDGFQGQEKEIILISCVRADDTKSSVGFLKDFRRMNVALTRAKTSIWVLGHQRSLAKSKLWRDLIEDAKDRSCLAYACSGFLDPRNNRAQSILRKFNVPVPSEQEDDYKLPMEYITQGPDEVKSNKDTKKRRVVDEGEEADKAVKKKKKEKKKEKKKSKADDKKKNNKKAESPSTSSGTKKKSSIFGGMSVPSAVVPKTFPDVDSNKKAAAVVGKKKNNKHVCFSDDVSFIPRNDEPEIKVTRSLSSVLKEKQLGLKETRTISPPEISNNEDDDDEDDYTPSISDSSLMKSEANGRNNRVASHNQNFSASIYDDPQVSQAKQTQVPAAITKHRSSNSVLSGGSSRILTASDYGEPNQNGQNGANRTLSQHVGNANQYSTAPVGTGELHETLPAHPQDSYPAEAEDPYDLNPHPQPQSSAFKGPGSGPTGTRNSSRRNASSSPFIPKKRKPRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | NNPDNNNSNNINNNN CCCCCCCCCCCCCCC | 33.12 | 24909858 | |
| 333 | Acetylation | ESLKKTFKFPLEPIF HHHHHHHCCCCHHHH | 51.83 | 24489116 | |
| 863 | Phosphorylation | SCVRLIISTSDLAHE HHHHHHHCCCHHCCH | 18.18 | 23749301 | |
| 871 | Ubiquitination | TSDLAHEKHVKVDDS CCHHCCHHCCCCCHH | 43.78 | 23749301 | |
| 943 | Phosphorylation | LGKVIDLTDSVPASP HCCEEECCCCCCCCC | 23.60 | 30377154 | |
| 945 | Phosphorylation | KVIDLTDSVPASPSL CEEECCCCCCCCCCC | 25.43 | 19779198 | |
| 949 | Phosphorylation | LTDSVPASPSLSPSL CCCCCCCCCCCCCCH | 14.67 | 30377154 | |
| 951 | Phosphorylation | DSVPASPSLSPSLSS CCCCCCCCCCCCHHH | 38.70 | 19779198 | |
| 958 | Phosphorylation | SLSPSLSSTIASSSA CCCCCHHHHHHCCCH | 29.17 | 27017623 | |
| 978 | Phosphorylation | YLQRKALSSSITGRP HHHHHHHHHCCCCCC | 27.22 | 30377154 | |
| 980 | Phosphorylation | QRKALSSSITGRPRV HHHHHHHCCCCCCCC | 22.31 | 30377154 | |
| 993 | Phosphorylation | RVAQPKITSFGTFQS CCCCCEECCCCCCCC | 24.91 | 30377154 | |
| 994 | Phosphorylation | VAQPKITSFGTFQSS CCCCEECCCCCCCCC | 25.75 | 30377154 | |
| 1000 | Phosphorylation | TSFGTFQSSANAKLH CCCCCCCCCHHCCCC | 27.51 | 30377154 | |
| 1001 | Phosphorylation | SFGTFQSSANAKLHR CCCCCCCCHHCCCCC | 18.11 | 30377154 | |
| 1043 | Phosphorylation | APAFHTKSRGLSNKN CCCCCCCCCCCCCCC | 32.51 | 24961812 | |
| 1047 | Phosphorylation | HTKSRGLSNKNDDSS CCCCCCCCCCCCCCC | 48.89 | 23749301 | |
| 1053 | Phosphorylation | LSNKNDDSSSEESDN CCCCCCCCCCCCCCC | 38.33 | 23749301 | |
| 1054 | Phosphorylation | SNKNDDSSSEESDND CCCCCCCCCCCCCCH | 49.08 | 23749301 | |
| 1055 | Phosphorylation | NKNDDSSSEESDNDI CCCCCCCCCCCCCHH | 49.70 | 23749301 | |
| 1058 | Phosphorylation | DDSSSEESDNDIESA CCCCCCCCCCHHHHH | 37.35 | 23749301 | |
| 1064 | Phosphorylation | ESDNDIESARELFAI CCCCHHHHHHHHHHH | 32.72 | 24961812 | |
| 1382 | Phosphorylation | LSTKNASSSNVIKVP HCCCCCCCCCCEEEE | 24.42 | 30377154 | |
| 1395 | Phosphorylation | VPLEKNSSNTEQLLK EECCCCCCCHHHHHH | 58.10 | 30377154 | |
| 1487 | Phosphorylation | RKFNNAVTKRRELRG HHHHHHHHHHHHHHC | 19.20 | 28889911 | |
| 1505 | Phosphorylation | SESGNPESPMSTEDI CCCCCCCCCCCHHHH | 27.45 | 23749301 | |
| 1508 | Phosphorylation | GNPESPMSTEDISKL CCCCCCCCHHHHHHH | 31.84 | 24961812 | |
| 1509 | Phosphorylation | NPESPMSTEDISKLQ CCCCCCCHHHHHHHH | 31.27 | 24961812 | |
| 1794 | Phosphorylation | EKEIILISCVRADDT EEEEEEEEEEECCCC | 11.78 | 21551504 | |
| 1819 | Phosphorylation | RRMNVALTRAKTSIW HHHHHHHHHHHHHHH | 20.88 | 24909858 | |
| 1951 | Phosphorylation | KNNKKAESPSTSSGT HCCCCCCCCCCCCCC | 29.07 | 22890988 | |
| 1953 | Phosphorylation | NKKAESPSTSSGTKK CCCCCCCCCCCCCCC | 50.64 | 22890988 | |
| 1954 | Phosphorylation | KKAESPSTSSGTKKK CCCCCCCCCCCCCCC | 30.23 | 22890988 | |
| 1955 | Phosphorylation | KAESPSTSSGTKKKS CCCCCCCCCCCCCCC | 30.98 | 22890988 | |
| 1956 | Phosphorylation | AESPSTSSGTKKKSS CCCCCCCCCCCCCCC | 51.04 | 22890988 | |
| 1958 | Phosphorylation | SPSTSSGTKKKSSIF CCCCCCCCCCCCCCC | 41.46 | 22890988 | |
| 2023 | Phosphorylation | PEIKVTRSLSSVLKE CCHHCCHHHHHHHHH | 24.20 | 21551504 | |
| 2025 | Phosphorylation | IKVTRSLSSVLKEKQ HHCCHHHHHHHHHHH | 21.46 | 21440633 | |
| 2036 | Acetylation | KEKQLGLKETRTISP HHHHHCCCCCEECCC | 56.06 | 25381059 | |
| 2042 | Phosphorylation | LKETRTISPPEISNN CCCCEECCCCCCCCC | 33.51 | 21440633 | |
| 2047 | Phosphorylation | TISPPEISNNEDDDD ECCCCCCCCCCCCCC | 31.76 | 21551504 | |
| 2102 | Phosphorylation | QVSQAKQTQVPAAIT CHHHHHHCCCCCCHH | 30.72 | 28889911 | |
| 2113 | Phosphorylation | AAITKHRSSNSVLSG CCHHCCCCCCCCCCC | 33.32 | 30377154 | |
| 2116 | Phosphorylation | TKHRSSNSVLSGGSS HCCCCCCCCCCCCCC | 26.78 | 30377154 | |
| 2119 | Phosphorylation | RSSNSVLSGGSSRIL CCCCCCCCCCCCEEE | 38.66 | 30377154 | |
| 2123 | Phosphorylation | SVLSGGSSRILTASD CCCCCCCCEEEEHHH | 26.98 | 28889911 | |
| 2218 | Phosphorylation | NSSRRNASSSPFIPK CCCCCCCCCCCCCCC | 34.59 | 21126336 | |
| 2220 | Phosphorylation | SRRNASSSPFIPKKR CCCCCCCCCCCCCCC | 22.72 | 30377154 | |
| 2225 | Acetylation | SSSPFIPKKRKPRS- CCCCCCCCCCCCCC- | 61.46 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEN1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEN1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEN1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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