| UniProt ID | COG6_YEAST | |
|---|---|---|
| UniProt AC | P53959 | |
| Protein Name | Conserved oligomeric Golgi complex subunit 6 | |
| Gene Name | COG6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 839 | |
| Subcellular Localization |
Golgi apparatus membrane Peripheral membrane protein. |
|
| Protein Description | Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.. | |
| Protein Sequence | MDFVVDYQTYAMADTATPELPEPEPRLNLTSDAQSQPTGKLDLQFKLPDLQRYSNNNATLPVDNDGAGSKDLHKKMTHYAMSSIDKIQLSNPSKQLGQNSQDEKLSQQESQNFTNYEPKNLDLSKLVSPSSGSNKNTTNLVLSNKLSKILNNYTLINYQATVQLRKSLKVLEENKERLSLDEQKLMNPEYVGTLARRALRTDLESQLLKEHITVLEEFKPIIRRIKRLSSSVEKIQRTSEKLLSNETNEVPTNNVVLQEIDQYRLKAEQLKLKKKILLSIRDRFTLNQVEDDVITNGTIDNIFFEVVKKVINIKDESSFLLTLPNLNAGNALIMGVNEILEKTNKKIFNYLIDFLYSFESSSNLLNDHGTTEQESLNIFRKSLVFLSSDLELFNELLKRVTTLRSKSILDEFLSQFDMNSTTSKPIILSAHDPIRYIGDVLASVHSIIANEADFVKSLFDFQDEDLKDTPISILQQNKTFLKGIDNKLLNDIIQSLSNSCRIRIEQIVRFEENPIINFEIVRLLKLYRVMFERKGIQDDSSIINNLKSLEDISKNRIIGYYEDYMKQTVMAETKNSSDDLLPPEWLSEYMNKLVELFEIYEKTHAAEDEESEDNKLLSSKNLQTIVEQPIKDVLLKQLQTSFPLAKKNEKEKASLLTIEINCFDLIKSRLQPFEGLFAQDDDSRKITIWVCDKLKEYTKQMLTLQIKFLFENTGLDLYSNLVNMIFPVDSVKDELDYDMYLALRDNSLMELDMVRKNVHDKLNYYLPQALTDVQGNLLFKLTSPMIADEICDECFKKLSLFYNIFRKLLIHLYPNKKDQVFEILNFSTDEFDMLIGIDH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 77 | Phosphorylation | KDLHKKMTHYAMSSI HHHHHHHHHHHHHHC | 22.18 | 27017623 | |
| 79 | Phosphorylation | LHKKMTHYAMSSIDK HHHHHHHHHHHHCCC | 8.54 | 27017623 | |
| 82 | Phosphorylation | KMTHYAMSSIDKIQL HHHHHHHHHCCCCCC | 18.90 | 26447709 | |
| 83 | Phosphorylation | MTHYAMSSIDKIQLS HHHHHHHHCCCCCCC | 23.01 | 25704821 | |
| 90 | Phosphorylation | SIDKIQLSNPSKQLG HCCCCCCCCCCHHCC | 30.25 | 26447709 | |
| 93 | Phosphorylation | KIQLSNPSKQLGQNS CCCCCCCCHHCCCCC | 36.97 | 26447709 | |
| 128 | Phosphorylation | LDLSKLVSPSSGSNK CCHHHHCCCCCCCCC | 29.51 | 25752575 | |
| 193 | Phosphorylation | MNPEYVGTLARRALR HCHHHHHHHHHHHHH | 13.75 | 19779198 | |
| 219 | Acetylation | ITVLEEFKPIIRRIK HHHHHHHHHHHHHHH | 38.29 | 24489116 | |
| 229 | Phosphorylation | IRRIKRLSSSVEKIQ HHHHHHHHHHHHHHH | 25.30 | 23749301 | |
| 322 | Phosphorylation | DESSFLLTLPNLNAG CCCCEEEECCCCCHH | 42.17 | 23749301 | |
| 343 | Phosphorylation | VNEILEKTNKKIFNY HHHHHHHHCHHHHHH | 42.78 | 23749301 | |
| 382 | Phosphorylation | SLNIFRKSLVFLSSD HHHHHHHHHHHHHHC | 26.05 | 23607784 | |
| 387 | Phosphorylation | RKSLVFLSSDLELFN HHHHHHHHHCHHHHH | 15.44 | 23607784 | |
| 388 | Phosphorylation | KSLVFLSSDLELFNE HHHHHHHHCHHHHHH | 48.65 | 23607784 | |
| 540 | Phosphorylation | RKGIQDDSSIINNLK CCCCCCCHHHHHHCC | 31.55 | 29136822 | |
| 541 | Phosphorylation | KGIQDDSSIINNLKS CCCCCCHHHHHHCCC | 34.19 | 29136822 | |
| 548 | Phosphorylation | SIINNLKSLEDISKN HHHHHCCCHHHHHHC | 39.91 | 28889911 | |
| 553 | Phosphorylation | LKSLEDISKNRIIGY CCCHHHHHHCCCCCH | 35.88 | 28889911 | |
| 600 | Phosphorylation | LVELFEIYEKTHAAE HHHHHHHHHHHCCCC | 12.27 | 22890988 | |
| 603 | Phosphorylation | LFEIYEKTHAAEDEE HHHHHHHHCCCCCCC | 12.57 | 22890988 | |
| 611 | Phosphorylation | HAAEDEESEDNKLLS CCCCCCCCCCCCCCC | 48.48 | 22890988 | |
| 618 | Phosphorylation | SEDNKLLSSKNLQTI CCCCCCCCCCCHHHH | 50.10 | 22890988 | |
| 619 | Phosphorylation | EDNKLLSSKNLQTIV CCCCCCCCCCHHHHH | 26.07 | 22890988 | |
| 640 | Phosphorylation | VLLKQLQTSFPLAKK HHHHHHHHHCCCCCC | 40.71 | 19823750 | |
| 641 | Phosphorylation | LLKQLQTSFPLAKKN HHHHHHHHCCCCCCC | 16.35 | 19823750 | |
| 697 | Phosphorylation | VCDKLKEYTKQMLTL ECHHHHHHHHHHHHH | 20.04 | 27017623 | |
| 698 | Phosphorylation | CDKLKEYTKQMLTLQ CHHHHHHHHHHHHHH | 18.85 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COG6_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COG6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COG6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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