MTC4_YEAST - dbPTM
MTC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTC4_YEAST
UniProt AC P38335
Protein Name Maintenance of telomere capping protein 4
Gene Name MTC4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 694
Subcellular Localization Membrane
Single-pass membrane protein . Cytoplasm . Punctate pattern.
Protein Description
Protein Sequence MTHTNEHDHKAEQQQNGRGDTTTETVNPQKMKLVTKLLIDNKFGLMDDLNFSIPLTASSEGVPISAKTSELGTEYLKNQQENSVSPILPISRSTRIKADRVRIYLDYYYNILERCISIDSSQNHHEGVEGVYNPLQVIRNRKLKKKHHELPTREFYTTKHPIIAIKQFSKKPNKKMPWFVDINEKYMDLTWRTSHWEELVDPQGKLWFQSYSPSNESSGSSSSRRHHGHHIHPRRHLQHHSRVRTANSVHSNTQSLTPKRVMTNEEDNNNHNNNNMITKIATTPEAQISRNKKSDLNLSHIHLEVPITNTVTNTSSDQGSLIIEAKGSSYGGDRRGSSNTSGSGGKRNSKHYRSKSAGPPENEKSRMNGLEKIISKTSKGWSRSPKKNTPGLEKQVLLNPTISNGGTSRRSSNNGESISTNSSKSSMGITFGNTETYKTPVDNGKDAIIRQSLLSEVPVHTLRGKTSNRSLRAEGEQALESDKELPNGAGSIYEGAPREKTTSQGSEPVGLVSDSLQVDEQLQRYWHDTRYIMSTVAMMQHRRETHDIVKRREIARRNEIEITQDADTNIRKTADALTQYDNELNKVLKLGNDWTSKLLNDYSIRVETLISSSDRILSDINTTLTLKLKMFQENTERYVTVKVMRAQKMTKTIYRLLEFGIVLVLWTIWFLFSVLRSIRFTIFLVLKIIKALLW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationLKNQQENSVSPILPI
HHHCCCCCCCCCCCC		24.1823749301
85PhosphorylationNQQENSVSPILPISR
HCCCCCCCCCCCCCC		13.1725752575
212PhosphorylationKLWFQSYSPSNESSG
CEEEEEECCCCCCCC		27.4023749301
214PhosphorylationWFQSYSPSNESSGSS
EEEEECCCCCCCCCC		47.4923749301
223PhosphorylationESSGSSSSRRHHGHH
CCCCCCCCCCCCCCC		34.9723749301
245PhosphorylationQHHSRVRTANSVHSN
HHHHCCCCCCCCCCC		27.6023749301
248PhosphorylationSRVRTANSVHSNTQS
HCCCCCCCCCCCCCC		20.8123749301
251PhosphorylationRTANSVHSNTQSLTP
CCCCCCCCCCCCCCC		39.1423749301
253PhosphorylationANSVHSNTQSLTPKR
CCCCCCCCCCCCCCC		23.6623749301
255PhosphorylationSVHSNTQSLTPKRVM
CCCCCCCCCCCCCCC		31.9723749301
257PhosphorylationHSNTQSLTPKRVMTN
CCCCCCCCCCCCCCC		31.8223749301
263PhosphorylationLTPKRVMTNEEDNNN
CCCCCCCCCCCCCCC		36.3021551504
282PhosphorylationNMITKIATTPEAQIS
CCEEEEECCHHHHHH		46.4828152593
283PhosphorylationMITKIATTPEAQISR
CEEEEECCHHHHHHC		15.3122369663
289PhosphorylationTTPEAQISRNKKSDL
CCHHHHHHCCCCCCC		20.0921440633
356PhosphorylationSKHYRSKSAGPPENE
CCCCCCCCCCCCCCH		39.4428889911
401PhosphorylationKQVLLNPTISNGGTS
CEEEECCEECCCCCC		35.6430377154
403PhosphorylationVLLNPTISNGGTSRR
EEECCEECCCCCCCC		31.7228152593
407PhosphorylationPTISNGGTSRRSSNN
CEECCCCCCCCCCCC		22.0619779198
408PhosphorylationTISNGGTSRRSSNNG
EECCCCCCCCCCCCC		29.0423749301
411PhosphorylationNGGTSRRSSNNGESI
CCCCCCCCCCCCCCC		35.9928889911
412PhosphorylationGGTSRRSSNNGESIS
CCCCCCCCCCCCCCC		32.2923749301
422PhosphorylationGESISTNSSKSSMGI
CCCCCCCCCCCCCCE		38.9528889911
461PhosphorylationLSEVPVHTLRGKTSN
HHCCCCHHCCCCCCC		20.5524961812
466PhosphorylationVHTLRGKTSNRSLRA
CHHCCCCCCCCCHHH		33.7724961812
467PhosphorylationHTLRGKTSNRSLRAE
HHCCCCCCCCCHHHH		33.4620377248
470PhosphorylationRGKTSNRSLRAEGEQ
CCCCCCCCHHHHHHH		26.8521440633
481PhosphorylationEGEQALESDKELPNG
HHHHHHHCCCCCCCC		55.6321551504
491PhosphorylationELPNGAGSIYEGAPR
CCCCCCCCCCCCCCC		22.8221440633
493PhosphorylationPNGAGSIYEGAPREK
CCCCCCCCCCCCCCC		15.2628889911
572UbiquitinationDADTNIRKTADALTQ
CCCCCHHHHHHHHHH		44.2423749301
597UbiquitinationLGNDWTSKLLNDYSI
CCCHHHHHHHHHCCC		50.0123749301
603PhosphorylationSKLLNDYSIRVETLI
HHHHHHCCCEEEEEE		13.5423749301
629UbiquitinationTTLTLKLKMFQENTE
HHHEEEEEHHHHCCC		35.7623749301
638PhosphorylationFQENTERYVTVKVMR
HHHCCCEEEEEEHHH		8.3424930733
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSO2_YEASTSSO2genetic
16269340
PLMT_YEASTOPI3genetic
16269340
ATC3_YEASTDRS2genetic
16269340
GSF2_YEASTGSF2genetic
16269340
ELO3_YEASTELO3genetic
16269340
ERG2_YEASTERG2genetic
16269340
VPH2_YEASTVPH2genetic
16269340
TPO1_YEASTTPO1genetic
16269340
YEF3_YEASTYEL043Wgenetic
16269340
YB8B_YEASTYBR287Wgenetic
16269340
NCB5R_YEASTCBR1genetic
16269340
SUR2_YEASTSUR2genetic
16269340
PCY1_YEASTPCT1genetic
16269340
RTN1_YEASTRTN1genetic
16269340
BSD2_YEASTBSD2genetic
16269340
EMP46_YEASTEMP46genetic
16269340
ERFD_YEASTSHR5genetic
16269340
GET3_YEASTGET3genetic
16269340
TM115_YEASTYOL107Wgenetic
16269340
DGAT2_YEASTDGA1genetic
16269340
SCS2_YEASTSCS2genetic
16269340
SIR2_YEASTSIR2genetic
21902802
ERG6_YEASTERG6genetic
23891562
ROM2_YEASTROM2genetic
23891562
RV161_YEASTRVS161genetic
23891562
STE24_YEASTSTE24genetic
23891562
PLMT_YEASTOPI3genetic
23891562
GYP1_YEASTGYP1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
VPS5_YEASTVPS5genetic
23891562
ERG26_YEASTERG26genetic
23891562
MSMO_YEASTERG25genetic
23891562
ERG3_YEASTERG3genetic
23891562
ERG5_YEASTERG5genetic
23891562
PACC_YEASTRIM101genetic
23891562
ELO3_YEASTELO3genetic
23891562
ERG1_YEASTERG1genetic
23891562
SEC5_YEASTSEC5genetic
23891562
CSG2_YEASTCSG2genetic
23891562
SSO2_YEASTSSO2genetic
23891562
ECM30_YEASTECM30genetic
23891562
SCS2_YEASTSCS2genetic
23891562
ATG32_YEASTATG32genetic
27708008
APC11_YEASTAPC11genetic
27708008
ARP2_YEASTARP2genetic
27708008
DPOD_YEASTPOL3genetic
27708008
RPB1_YEASTRPO21genetic
27708008
NOP14_YEASTNOP14genetic
27708008
RIFK_YEASTFMN1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
ACT_YEASTACT1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
CP51_YEASTERG11genetic
27708008
ARPC5_YEASTARC15genetic
27708008
OST1_YEASTOST1genetic
27708008
HSP77_YEASTSSC1genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
ERG27_YEASTERG27genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LCB1_YEASTLCB1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
ARPC2_YEASTARC35genetic
27708008
MVD1_YEASTMVD1genetic
27708008
PROF_YEASTPFY1genetic
27708008
LAS17_YEASTLAS17genetic
27708008
MOT1_YEASTMOT1genetic
27708008
SEC62_YEASTSEC62genetic
27708008
VPS8_YEASTVPS8genetic
27708008
ATC3_YEASTDRS2genetic
27708008
ETR1_YEASTETR1genetic
27708008
RV161_YEASTRVS161genetic
27708008
SWF1_YEASTSWF1genetic
27708008
ARO1_YEASTARO1genetic
27708008
RTN1_YEASTRTN1genetic
27708008
TPA1_YEASTTPA1genetic
27708008
GIP2_YEASTGIP2genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MSH4_YEASTMSH4genetic
27708008
AROC_YEASTARO2genetic
27708008
ASK10_YEASTASK10genetic
27708008
VMA21_YEASTVMA21genetic
27708008
THIK_YEASTPOT1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
FABG_YEASTOAR1genetic
27708008
LST4_YEASTLST4genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ERG3_YEASTERG3genetic
27708008
SSO2_YEASTSSO2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
MSN1_YEASTMSN1genetic
27708008
FABD_YEASTMCT1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP066_YEASTRGL1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; THR-263; THR-283 ANDSER-481, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283, AND MASSSPECTROMETRY.

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