VPS5_YEAST - dbPTM
VPS5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS5_YEAST
UniProt AC Q92331
Protein Name Vacuolar protein sorting-associated protein 5
Gene Name VPS5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 675
Subcellular Localization Cytoplasm. Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side . Endosome membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation..
Protein Sequence MDYEDNLEAPVWDELNHEGDKTQSLVSNSIESIGQISTNEERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGNPQLEEHDNSKADDLINSLAPEQDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYDANTSPNTSKSISGRRSGKPRILFDSARAQRNSKRNHSLKAKRTTASDDTIKTPFTDPLKKAEKENEFVEEPLDDRNERRENNEGKFTASVEKNILEQVDRPLYNLPQTGANISSPAEVEENSEKFGKTKIGSKVPPTEKAVAFKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQLLGAEDAAEVLKNGGIDAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLSKSLEMVDTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIKDEFQGFSTDKIREFRNGMEISLEAAIESQKECIELWETFYQTNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationLNHEGDKTQSLVSNS
CCCCCHHHHHHHHHH		28.2922369663
24PhosphorylationHEGDKTQSLVSNSIE
CCCHHHHHHHHHHHH		35.6519795423
27PhosphorylationDKTQSLVSNSIESIG
HHHHHHHHHHHHHHH		30.1022369663
29PhosphorylationTQSLVSNSIESIGQI
HHHHHHHHHHHHHCC		21.8922369663
32PhosphorylationLVSNSIESIGQISTN
HHHHHHHHHHCCCCC		30.2822369663
37PhosphorylationIESIGQISTNEERKD
HHHHHCCCCCCHHHH		19.7922369663
38PhosphorylationESIGQISTNEERKDN
HHHHCCCCCCHHHHC		48.5622369663
50PhosphorylationKDNELLETTASFADK
HHCHHHHHHHHHHHH		27.8622369663
51PhosphorylationDNELLETTASFADKI
HCHHHHHHHHHHHHC		15.7822369663
53PhosphorylationELLETTASFADKIDL
HHHHHHHHHHHHCCC		20.9022369663
62PhosphorylationADKIDLDSAPEWKDP
HHHCCCCCCCCCCCC		53.6822369663
72PhosphorylationEWKDPGLSVAGNPQL
CCCCCCCCCCCCCCC		18.8122369663
85PhosphorylationQLEEHDNSKADDLIN
CCCCCCCCCHHHHHH		34.9728889911
93PhosphorylationKADDLINSLAPEQDP
CHHHHHHHCCCCCCC		20.9324961812
107PhosphorylationPIADLKNSTTQFIAT
CHHHCCCCCCEEEEE		31.1122369663
108PhosphorylationIADLKNSTTQFIATR
HHHCCCCCCEEEEEE		33.7322369663
109PhosphorylationADLKNSTTQFIATRE
HHCCCCCCEEEEEEC		22.6922369663
141PhosphorylationDTIYDANTSPNTSKS
CEEEECCCCCCCCCC		47.4821440633
142PhosphorylationTIYDANTSPNTSKSI
EEEECCCCCCCCCCC		18.8928152593
145PhosphorylationDANTSPNTSKSISGR
ECCCCCCCCCCCCCC		40.7030377154
181PhosphorylationHSLKAKRTTASDDTI
CCCCCCCCCCCCCCC		26.4624961812
182PhosphorylationSLKAKRTTASDDTIK
CCCCCCCCCCCCCCC		28.3521440633
184PhosphorylationKAKRTTASDDTIKTP
CCCCCCCCCCCCCCC		33.6517563356
187PhosphorylationRTTASDDTIKTPFTD
CCCCCCCCCCCCCCC		29.3925752575
190PhosphorylationASDDTIKTPFTDPLK
CCCCCCCCCCCCHHH		21.5621440633
246PhosphorylationPLYNLPQTGANISSP
CCCCCCCCCCCCCCH		36.0022369663
251PhosphorylationPQTGANISSPAEVEE
CCCCCCCCCHHHHHH		30.0322369663
252PhosphorylationQTGANISSPAEVEEN
CCCCCCCCHHHHHHH		25.0822369663
262UbiquitinationEVEENSEKFGKTKIG
HHHHHHHHHCCCCCC		60.2723749301
346AcetylationVIPPPPEKQSVGSFK
CCCCCCCCCCCCCHH		54.3624489116
348PhosphorylationPPPPEKQSVGSFKEN
CCCCCCCCCCCHHHH		39.2430377154
449PhosphorylationESHKGFMSISFSSLP
CCCCCCEEEEHHHCC		16.9030377154
451PhosphorylationHKGFMSISFSSLPKY
CCCCEEEEHHHCCCC		16.2730377154
453PhosphorylationGFMSISFSSLPKYNE
CCEEEEHHHCCCCCC		24.9530377154
454PhosphorylationFMSISFSSLPKYNEA
CEEEEHHHCCCCCCC		46.8330377154
468AcetylationADEFFIEKKQKIDEL
CCCHHHHHHHHHHHH		56.5424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEP8_YEASTPEP8physical
11598206
VPS17_YEASTVPS17physical
11598206
VPS35_YEASTVPS35physical
11598206
VPS29_YEASTVPS29physical
9700157
VPS35_YEASTVPS35physical
9700157
VPS17_YEASTVPS17physical
9285823
VPS17_YEASTVPS17physical
9700157
VPS17_YEASTVPS17physical
12181349
PEP8_YEASTPEP8physical
16554755
SSB2_YEASTSSB2physical
16554755
MUK1_YEASTMUK1physical
16554755
BUB1_YEASTBUB1physical
15263065
VPS17_YEASTVPS17physical
15263065
VPS35_YEASTVPS35physical
15263065
SNAPN_YEASTSNN1physical
15263065
YIF1_YEASTYIF1physical
15263065
VPS35_YEASTVPS35physical
17696874
VPS17_YEASTVPS17physical
17696874
VPS29_YEASTVPS29physical
17696874
PEP8_YEASTPEP8physical
17696874
VPS5_YEASTVPS5physical
18467557
VPS17_YEASTVPS17physical
18467557
SSB2_YEASTSSB2physical
19536198
LDS1_YEASTLDS1genetic
20093466
VPS8_YEASTVPS8genetic
20093466
POA1_YEASTPOA1genetic
20093466
QOR_YEASTZTA1genetic
20093466
ECM33_YEASTECM33genetic
20093466
PP2C4_YEASTPTC4genetic
20093466
YBY9_YEASTYBR139Wgenetic
20093466
AMN1_YEASTAMN1genetic
20093466
RGD1_YEASTRGD1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
THRC_YEASTTHR4genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
THI3_YEASTTHI3genetic
20093466
VAM6_YEASTVAM6genetic
20093466
VPS41_YEASTVPS41genetic
20093466
MSN5_YEASTMSN5genetic
20093466
HKR1_YEASTHKR1genetic
20093466
SNX41_YEASTSNX41genetic
20093466
STL1_YEASTSTL1genetic
20093466
BMH1_YEASTBMH1genetic
20093466
VAM7_YEASTVAM7genetic
20093466
AAKG_YEASTSNF4genetic
20093466
COG7_YEASTCOG7genetic
20093466
PEF1_YEASTPEF1genetic
20093466
PACC_YEASTRIM101genetic
20093466
NPR3_YEASTNPR3genetic
20093466
YHA8_YEASTYHL008Cgenetic
20093466
HSE1_YEASTHSE1genetic
20093466
VPS29_YEASTVPS29genetic
20093466
SLT2_YEASTSLT2genetic
20093466
LRP1_YEASTLRP1genetic
20093466
CHS7_YEASTCHS7genetic
20093466
VPS35_YEASTVPS35genetic
20093466
BCK1_YEASTBCK1genetic
20093466
PEP8_YEASTPEP8genetic
20093466
SYS1_YEASTSYS1genetic
20093466
HOC1_YEASTHOC1genetic
20093466
LDB18_YEASTLDB18genetic
20093466
VPS13_YEASTVPS13genetic
20093466
VPS38_YEASTVPS38genetic
20093466
VPS9_YEASTVPS9genetic
20093466
COG8_YEASTCOG8genetic
20093466
MSN2_YEASTMSN2genetic
20093466
PALI_YEASTRIM9genetic
20093466
GBLP_YEASTASC1genetic
20093466
RIM13_YEASTRIM13genetic
20093466
YM79_YEASTYMR244Wgenetic
20093466
LSM7_YEASTLSM7genetic
20093466
EOS1_YEASTEOS1genetic
20093466
OCA2_YEASTOCA2genetic
20093466
COG5_YEASTCOG5genetic
20093466
COG6_YEASTCOG6genetic
20093466
ATG3_YEASTATG3genetic
20093466
CYP8_YEASTCPR8genetic
20093466
BRE5_YEASTBRE5genetic
20093466
PALA_YEASTRIM20genetic
20093466
TGS1_YEASTTGS1genetic
20093466
ATG21_YEASTATG21genetic
20093466
ARL3_YEASTARL3genetic
20093466
TGL4_YEASTTGL4genetic
20379744
YPT31_YEASTYPT31genetic
20526336
VTA1_YEASTVTA1genetic
20526336
SRS2_YEASTSRS2genetic
21459050
VPS5_YEASTVPS5physical
22615397
ERG26_YEASTERG26genetic
23891562
MSMO_YEASTERG25genetic
23891562
ERG3_YEASTERG3genetic
23891562
PACC_YEASTRIM101genetic
23891562
PALF_YEASTRIM8genetic
23891562
PALH_YEASTRIM21genetic
23891562
ECM14_YEASTECM14genetic
23891562
FEN1_YEASTRAD27genetic
23891562
ELO3_YEASTELO3genetic
23891562
SUR1_YEASTSUR1genetic
23891562
THIL_YEASTERG10genetic
23891562
TPM1_YEASTTPM1genetic
23891562
VPS55_YEASTVPS55genetic
23891562
PSK2_YEASTPSK2genetic
23891562
SLT2_YEASTSLT2genetic
22282571
VPS5_YEASTVPS5physical
9700157
CDC1_YEASTCDC1genetic
27708008
VPS8_YEASTVPS8genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
SWF1_YEASTSWF1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
VPS29_YEASTVPS29genetic
27708008
PEP8_YEASTPEP8genetic
27708008
VPS35_YEASTVPS35genetic
27708008
VPS13_YEASTVPS13genetic
27708008
VPS38_YEASTVPS38genetic
27708008
VPS9_YEASTVPS9genetic
27708008
SCS7_YEASTSCS7genetic
27708008
NSE4_YEASTNSE4genetic
27708008
RRP1_YEASTRRP1genetic
27708008
COPB_YEASTSEC26genetic
27708008
TRS23_YEASTTRS23genetic
27708008
GPI8_YEASTGPI8genetic
27708008
COG3_YEASTCOG3genetic
27708008
COPD_YEASTRET2genetic
27708008
STT3_YEASTSTT3genetic
27708008
DUO1_YEASTDUO1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
YKT6_YEASTYKT6genetic
27708008
RSC4_YEASTRSC4genetic
27708008
SED5_YEASTSED5genetic
27708008
POB3_YEASTPOB3genetic
27708008
UTP15_YEASTUTP15genetic
27708008
VTI1_YEASTVTI1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DCP2_YEASTDCP2genetic
27708008
COPZ_YEASTRET3genetic
27708008
NIP7_YEASTNIP7genetic
27708008
DPM1_YEASTDPM1genetic
27708008
LDS1_YEASTLDS1genetic
27708008
UBP13_YEASTUBP13genetic
27708008
GAL10_YEASTGAL10genetic
27708008
QOR_YEASTZTA1genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
AMN1_YEASTAMN1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
OST4_YEASTOST4genetic
27708008
VPS41_YEASTVPS41genetic
27708008
INO2_YEASTINO2genetic
27708008
SWA2_YEASTSWA2genetic
27708008
SAC7_YEASTSAC7genetic
27708008
SNX41_YEASTSNX41genetic
27708008
CEM1_YEASTCEM1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
YHA8_YEASTYHL008Cgenetic
27708008
GOSR1_YEASTGOS1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
LRP1_YEASTLRP1genetic
27708008
GGA2_YEASTGGA2genetic
27708008
HPM1_YEASTHPM1genetic
27708008
SYS1_YEASTSYS1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
COG8_YEASTCOG8genetic
27708008
YM24_YEASTYMR147Wgenetic
27708008
YM79_YEASTYMR244Wgenetic
27708008
ELP6_YEASTELP6genetic
27708008
TGL3_YEASTTGL3genetic
27708008
COG6_YEASTCOG6genetic
27708008
YNN4_YEASTYNL134Cgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
PFD4_YEASTGIM3genetic
27708008
ATG3_YEASTATG3genetic
27708008
PMA2_YEASTPMA2genetic
27708008
BEM4_YEASTBEM4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-142, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184 AND SER-252, ANDMASS SPECTROMETRY.

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