YIF1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YIF1_YEAST
• UniProt AC: P53845
• Protein Name: Protein transport protein YIF1
• Gene Name: YIF1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 314
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle . Also found in ER-derived COPII-coated vesicles.
• Protein Description: Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases..
• Protein Sequence: MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRNTPVNGQGNANMNANVNGSGGGFPFQDPRGSMAFQLGQSAFSNFIGQDNFNQFQETVNKATANAAGSQQISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMGLVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFNLLSRSGAEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYNPYAYA ------CCCCCCCCC	33.35	22814378
10	Phosphorylation	YNPYAYATSEQNGVN CCCCCCCCCCCCCCC	21.81	30377154
21	Phosphorylation	NGVNDRFSHTPQQQR CCCCCCCCCCCCCCC	27.61	19779198
23	Phosphorylation	VNDRFSHTPQQQRPM CCCCCCCCCCCCCCC	22.92	28889911
36	Phosphorylation	PMQIPRNTPVNGQGN CCCCCCCCCCCCCCC	29.87	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YIF1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YIF1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YIF1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YIP1_YEAST	YIP1	physical	10970842
SEC4_YEAST	SEC4	physical	11943201
YPT1_YEAST	YPT1	physical	11943201
YPT10_YEAST	YPT10	physical	11943201
YPT11_YEAST	YPT11	physical	11943201
YPT31_YEAST	YPT31	physical	11943201
YPT32_YEAST	YPT32	physical	11943201
YPT52_YEAST	YPT52	physical	11943201
YPT6_YEAST	YPT6	physical	11943201
YPT7_YEAST	YPT7	physical	11943201
VPS21_YEAST	VPS21	physical	11943201
YIP4_YEAST	YIP4	physical	11943201
YPT53_YEAST	YPT53	physical	11943201
SEC4_YEAST	SEC4	physical	10970842
YPT1_YEAST	YPT1	physical	10970842
YPT31_YEAST	YPT31	physical	10970842
YIP1_YEAST	YIP1	physical	15659647
YOS1_YEAST	YOS1	physical	15659647
YIP1_YEAST	YIP1	physical	11283351
PRA1_YEAST	YIP3	physical	11283351
PRA1_YEAST	YIP3	physical	18719252
YOP1_YEAST	YOP1	physical	18719252
GST1_YEAST	GTT1	physical	18719252
MGA2_YEAST	MGA2	physical	18719252
PEX29_YEAST	PEX29	physical	18719252
UIP3_YEAST	UIP3	physical	18719252
BEM1_YEAST	BEM1	genetic	20093466
STE50_YEAST	STE50	genetic	20093466
RT103_YEAST	RTT103	genetic	20093466
ERV14_YEAST	ERV14	genetic	20093466
CHO2_YEAST	CHO2	genetic	20093466
PLMT_YEAST	OPI3	genetic	20093466
SAC1_YEAST	SAC1	genetic	20093466
ENV10_YEAST	ENV10	genetic	20093466
ALAM_YEAST	ALT1	genetic	20093466
MSC1_YEAST	MSC1	genetic	20093466
ROY1_YEAST	ROY1	genetic	20093466
EFM6_YEAST	YNL024C	genetic	20093466
KU70_YEAST	YKU70	genetic	22345352
SIZ2_YEAST	NFI1	genetic	22345352
REEP6_HUMAN	REEP6	physical	27107014
AR6P1_HUMAN	ARL6IP1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.