| UniProt ID | BEM1_YEAST | |
|---|---|---|
| UniProt AC | P29366 | |
| Protein Name | Bud emergence protein 1 | |
| Gene Name | BEM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 551 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.. | |
| Protein Sequence | MLKNFKLSKRDSNGSKGRITSADISTPSHDNGSVIKHIKTVPVRYLSSSSTPVKSQRDSSPKNRHNSKDITSPEKVIKAKYSYQAQTSKELSFMEGEFFYVSGDEKDWYKASNPSTGKEGVVPKTYFEVFDRTKPSSVNGSNSSSRKVTNDSLNMGSLYAIVLYDFKAEKADELTTYVGENLFICAHHNCEWFIAKPIGRLGGPGLVPVGFVSIIDIATGYATGNDVIEDIKSVNLPTVQEWKSNIARYKASNISLGSVEQQQQQSITKPQNKSAKLVDGELLVKASVESFGLEDEKYWFLVCCELSNGKTRQLKRYYQDFYDLQVQLLDAFPAEAGKLRDAGGQWSKRIMPYIPGPVPYVTNSITKKRKEDLNIYVADLVNLPDYISRSEMVHSLFVVLNNGFDREFERDENQNNIKTLQENDTATFATASQTSNFASTNQDNTLTGEDLKLNKKLSDLSLSGSKQAPAQSTSGLKTTKIKFYYKDDIFALMLKGDTTYKELRSKIAPRIDTDNFKLQTKLFDGSGEEIKTDSQVSNIIQAKLKISVHDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MLKNFKLS -------CCCCCCCC | 12.41 | 22814378 | |
| 20 | Phosphorylation | NGSKGRITSADISTP CCCCCEEEECCCCCC | 19.26 | 23749301 | |
| 21 | Phosphorylation | GSKGRITSADISTPS CCCCEEEECCCCCCC | 22.90 | 19823750 | |
| 25 | Phosphorylation | RITSADISTPSHDNG EEEECCCCCCCCCCC | 34.51 | 24961812 | |
| 26 | Phosphorylation | ITSADISTPSHDNGS EEECCCCCCCCCCCC | 29.19 | 21440633 | |
| 28 | Phosphorylation | SADISTPSHDNGSVI ECCCCCCCCCCCCCE | 43.49 | 21440633 | |
| 33 | Phosphorylation | TPSHDNGSVIKHIKT CCCCCCCCCEEEEEE | 27.24 | 21440633 | |
| 40 | Phosphorylation | SVIKHIKTVPVRYLS CCEEEEEEEEEEEEC | 29.46 | 19823750 | |
| 45 | Phosphorylation | IKTVPVRYLSSSSTP EEEEEEEEECCCCCC | 15.92 | 20377248 | |
| 47 | Phosphorylation | TVPVRYLSSSSTPVK EEEEEEECCCCCCCC | 21.17 | 22369663 | |
| 48 | Phosphorylation | VPVRYLSSSSTPVKS EEEEEECCCCCCCCC | 26.22 | 22369663 | |
| 49 | Phosphorylation | PVRYLSSSSTPVKSQ EEEEECCCCCCCCCC | 34.55 | 22369663 | |
| 50 | Phosphorylation | VRYLSSSSTPVKSQR EEEECCCCCCCCCCC | 38.38 | 22369663 | |
| 51 | Phosphorylation | RYLSSSSTPVKSQRD EEECCCCCCCCCCCC | 33.77 | 22369663 | |
| 67 | Phosphorylation | SPKNRHNSKDITSPE CCCCCCCCCCCCCHH | 26.11 | 17563356 | |
| 71 | Phosphorylation | RHNSKDITSPEKVIK CCCCCCCCCHHHHHH | 48.65 | 29734811 | |
| 72 | Phosphorylation | HNSKDITSPEKVIKA CCCCCCCCHHHHHHH | 31.25 | 25521595 | |
| 75 | Acetylation | KDITSPEKVIKAKYS CCCCCHHHHHHHEEE | 53.28 | 24489116 | |
| 80 | Acetylation | PEKVIKAKYSYQAQT HHHHHHHEEEECCCC | 29.72 | 25381059 | |
| 82 | Phosphorylation | KVIKAKYSYQAQTSK HHHHHEEEECCCCCC | 15.29 | 23749301 | |
| 88 | Phosphorylation | YSYQAQTSKELSFME EEECCCCCCEEEEEE | 16.44 | 28889911 | |
| 125 | Phosphorylation | KEGVVPKTYFEVFDR CCCCCCCHHEEEECC | 27.63 | 19823750 | |
| 126 | Phosphorylation | EGVVPKTYFEVFDRT CCCCCCHHEEEECCC | 12.13 | 19823750 | |
| 133 | Phosphorylation | YFEVFDRTKPSSVNG HEEEECCCCCCCCCC | 49.50 | 19823750 | |
| 136 | Phosphorylation | VFDRTKPSSVNGSNS EECCCCCCCCCCCCC | 48.77 | 19823750 | |
| 137 | Phosphorylation | FDRTKPSSVNGSNSS ECCCCCCCCCCCCCC | 28.29 | 23749301 | |
| 141 | Phosphorylation | KPSSVNGSNSSSRKV CCCCCCCCCCCCCCC | 28.47 | 21440633 | |
| 143 | Phosphorylation | SSVNGSNSSSRKVTN CCCCCCCCCCCCCCC | 31.24 | 23749301 | |
| 144 | Phosphorylation | SVNGSNSSSRKVTND CCCCCCCCCCCCCCC | 38.11 | 19823750 | |
| 145 | Phosphorylation | VNGSNSSSRKVTNDS CCCCCCCCCCCCCCC | 35.62 | 19823750 | |
| 244 | Phosphorylation | PTVQEWKSNIARYKA CCHHHHHHHHHHHHH | 34.24 | 24961812 | |
| 249 | Phosphorylation | WKSNIARYKASNISL HHHHHHHHHHHHCCC | 11.24 | 24961812 | |
| 252 | Phosphorylation | NIARYKASNISLGSV HHHHHHHHHCCCCCH | 30.46 | 22369663 | |
| 255 | Phosphorylation | RYKASNISLGSVEQQ HHHHHHCCCCCHHHH | 30.81 | 22369663 | |
| 258 | Phosphorylation | ASNISLGSVEQQQQQ HHHCCCCCHHHHHHH | 27.98 | 22369663 | |
| 266 | Phosphorylation | VEQQQQQSITKPQNK HHHHHHHCCCCCCCC | 28.08 | 22369663 | |
| 268 | Phosphorylation | QQQQQSITKPQNKSA HHHHHCCCCCCCCCC | 41.75 | 22369663 | |
| 276 | Acetylation | KPQNKSAKLVDGELL CCCCCCCCCCCCEEE | 57.01 | 24489116 | |
| 432 | Phosphorylation | TATFATASQTSNFAS CEEEEECCCCCCCCC | 29.63 | 21551504 | |
| 435 | Phosphorylation | FATASQTSNFASTNQ EEECCCCCCCCCCCC | 23.47 | 21551504 | |
| 445 | Phosphorylation | ASTNQDNTLTGEDLK CCCCCCCCCCHHHHH | 33.70 | 27017623 | |
| 447 | Phosphorylation | TNQDNTLTGEDLKLN CCCCCCCCHHHHHHC | 36.16 | 27017623 | |
| 458 | Phosphorylation | LKLNKKLSDLSLSGS HHHCHHHHHCCCCCC | 45.44 | 22369663 | |
| 461 | Phosphorylation | NKKLSDLSLSGSKQA CHHHHHCCCCCCCCC | 26.02 | 22369663 | |
| 463 | Phosphorylation | KLSDLSLSGSKQAPA HHHHCCCCCCCCCCC | 37.33 | 22890988 | |
| 465 | Phosphorylation | SDLSLSGSKQAPAQS HHCCCCCCCCCCCCC | 20.44 | 22890988 | |
| 517 | Acetylation | RIDTDNFKLQTKLFD CCCCCCCEEEEEECC | 46.04 | 24489116 | |
| 526 | Phosphorylation | QTKLFDGSGEEIKTD EEEECCCCCCCCCCH | 44.89 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BEM1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BEM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BEM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-72; SER-255;SER-258; SER-458 AND SER-461, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-72; SER-458 ANDSER-461, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458 AND SER-461, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458 AND SER-461, ANDMASS SPECTROMETRY. | |
