AFI1_YEAST - dbPTM
AFI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AFI1_YEAST
UniProt AC Q99222
Protein Name ARF3-interacting protein 1
Gene Name AFI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 893
Subcellular Localization Cytoplasm, perinuclear region. Cytoplasm, cell cortex. Enriched at the nuclear envelope and at the plasma membrane, especially in daughter cells and at the bud neck.
Protein Description Involved in actin patch polarization. Required for maintaining a proper budding pattern in yeast cells. Required for proper polarized localization of the ADP-ribosylation factor ARF3 at the plasma membrane..
Protein Sequence MLRRELNNSISNRSIENESFPFERPNVSYIISAEFDNKLGPILKHQYPKDIPGFNQFSHEQRNGNTSVSMNLASLMIPSSIERNPGKQDITVFTLYYNKFTQNYQLFPVPKDPRFSFNLHHREQSDGSVTNSIYYDAENHQDAKNNRYTIVLEDDELECQEVQNNQKAIDNEPLFFINVANTVLDTTNDRGAVIKSIAIGTPLKTFFAFKNIIVLVLDLYMKAPTQAAATDILLDCFNMLNSIDLTLINDIHSKSSIQEVLHSIHDESIITKVFLDPDSTLKKLFCINGFDTKDKYGNIVTFHDQLIQYHFTRFQPKTLPPFLLKIPLQFNMIRREPIYIENDYNELVLKFLDKFVPYLLKAGQKVNAWKLVINSTKLSKEDLCAFILSLANITATYASDPQSYFKGNAALIFPYMDISLVDGLRAYVASNSDFVGCFAIIGTANPIFRYQLDIWDYYYDVDEGVFYENNSPEKEKPDTVAEVKIGPNPLRKIFNRPHFSTNAVNESQVNLGQKLFSLLIDEYHDSDTIMSVLRRLNVLQLENLLDALKRREIPPNIALKDEYIMFYKDFFIFPEFFDYFTLHSIELLSNLDNCLFSLGNTCQLFSTEQIYSQLSQILDIVKELFRMVSVSRTNIEKFLNACLNYSPFKILPTAQLHGDNISRWSFESEVRQGFDNFNSYMGIEKDPHGVIVSAIDLFTQIYSFDILAFFLTFITKESGQDLPFTKSLSRRRTYLTRIAQSSSLRQFLQLSTRPNIRILGGNGQGTGNSNYPEFTNASSVISPKLRASPLLERRASKICYAITKLLYRLECHPIGMALLKKYLHNQLREAYLESKRHFISKKGDSTNTSSTIASSSFAGASVPLSSNESGMLNGLKQINEQQESTLETTQKED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationLRRELNNSISNRSIE
CHHHHHHCCCCCCCC		26.7328889911
14PhosphorylationNNSISNRSIENESFP
HHCCCCCCCCCCCCC		38.2127214570
101PhosphorylationTLYYNKFTQNYQLFP
EEEEECCCCCEEEEC		19.9529734811
104PhosphorylationYNKFTQNYQLFPVPK
EECCCCCEEEECCCC		9.2229734811
125PhosphorylationNLHHREQSDGSVTNS
ECCCCCCCCCCEEEE		38.9023749301
128PhosphorylationHREQSDGSVTNSIYY
CCCCCCCCEEEEEEE		30.6623749301
130PhosphorylationEQSDGSVTNSIYYDA
CCCCCCEEEEEEEEC		25.5823749301
132PhosphorylationSDGSVTNSIYYDAEN
CCCCEEEEEEEECCC		11.5523749301
144UbiquitinationAENHQDAKNNRYTIV
CCCCCCHHCCCEEEE		64.1523749301
255PhosphorylationINDIHSKSSIQEVLH
HCCCCCCHHHHHHHH		35.3727017623
256PhosphorylationNDIHSKSSIQEVLHS
CCCCCCHHHHHHHHH		31.8427017623
280PhosphorylationVFLDPDSTLKKLFCI
EEECCCCHHHHHHEE		50.4027017623
404PhosphorylationYASDPQSYFKGNAAL
ECCCHHHHHCCCEEE		12.2228132839
741PhosphorylationYLTRIAQSSSLRQFL
HHHHHHHCHHHHHHH		16.9330377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AFI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AFI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AFI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARF3_YEASTARF3physical
18397879
CNM67_YEASTCNM67physical
18719252
CNM67_YEASTCNM67genetic
14515169
ATG15_YEASTATG15genetic
27708008
VPS41_YEASTVPS41genetic
27708008
BFA1_YEASTBFA1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP9_YEASTPRP9genetic
27708008
FAL1_YEASTFAL1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC37_YEASTCDC37genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
COG3_YEASTCOG3genetic
27708008
GNA1_YEASTGNA1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
STS1_YEASTSTS1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
BET3_YEASTBET3genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NAB3_YEASTNAB3genetic
27708008
RT103_YEASTRTT103genetic
27708008
GCN20_YEASTGCN20genetic
27708008
ARI1_YEASTARI1genetic
27708008
ADH4_YEASTADH4genetic
27708008
G3P3_YEASTTDH3genetic
27708008
OPI1_YEASTOPI1genetic
27708008
ACA2_YEASTCST6genetic
27708008
RL34B_YEASTRPL34Bgenetic
27708008
ATG32_YEASTATG32genetic
27708008
NCA3_YEASTNCA3genetic
27708008
CTK1_YEASTCTK1genetic
27708008
UBX2_YEASTUBX2genetic
27708008
YNB0_YEASTYNL010Wgenetic
27708008
PHO23_YEASTPHO23genetic
27708008
OCA1_YEASTOCA1genetic
27708008
MSH2_YEASTMSH2genetic
27708008
VTS1_YEASTVTS1genetic
27708008
PHSG_YEASTGPH1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AFI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.

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