| UniProt ID | VPS41_YEAST | |
|---|---|---|
| UniProt AC | P38959 | |
| Protein Name | Vacuolar protein sorting-associated protein 41 | |
| Gene Name | VPS41 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 992 | |
| Subcellular Localization | Vacuole . | |
| Protein Description | Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.. | |
| Protein Sequence | MTTDNHQNDSVLDQQSGERTIDESNSISDENNVDNKREDVNVTSPTKSVSCISQAENGVASRTDESTITGSATDAETGDDDDDDDDDDDEDEDDEDEPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGILHLTTCAFEPIKTIKCHRSSILCINTDGKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQASRMFVSGGMAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGITFCDVPTRSQLLNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTKDSNSIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGLASFKDDQLLCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVDLFNGDEIYNDEVIMKNYEKLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQYYKAWKIGKYVIGSEERFSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQNVLKEWADIIEILITSGNIVEIAPLIPKKPALRKSVYDDVLHYFLANDMINKFHEYITKWDLKLFSVEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLPQYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFKKILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSLLPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDFVKNWGDSELWEFMINYSLDKPNFTKAILTCSDETSEIYLKVIRGMSDDLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDETKKFANEFLKIRSQGKLFQVDESDIEINDDLNGVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTTDNHQND ------CCCCCCCCC | 42.74 | 19823750 | |
| 3 | Phosphorylation | -----MTTDNHQNDS -----CCCCCCCCCC | 33.24 | 19823750 | |
| 10 | Phosphorylation | TDNHQNDSVLDQQSG CCCCCCCCCCCCCCC | 31.93 | 19823750 | |
| 16 | Phosphorylation | DSVLDQQSGERTIDE CCCCCCCCCCEECCC | 36.67 | 24909858 | |
| 20 | Phosphorylation | DQQSGERTIDESNSI CCCCCCEECCCCCCC | 28.60 | 19823750 | |
| 24 | Phosphorylation | GERTIDESNSISDEN CCEECCCCCCCCCCC | 31.93 | 22369663 | |
| 26 | Phosphorylation | RTIDESNSISDENNV EECCCCCCCCCCCCC | 32.52 | 22369663 | |
| 28 | Phosphorylation | IDESNSISDENNVDN CCCCCCCCCCCCCCC | 38.40 | 22369663 | |
| 43 | Phosphorylation | KREDVNVTSPTKSVS CCCCCCCCCCCCCCC | 24.64 | 19823750 | |
| 44 | Phosphorylation | REDVNVTSPTKSVSC CCCCCCCCCCCCCCH | 26.70 | 25521595 | |
| 46 | Phosphorylation | DVNVTSPTKSVSCIS CCCCCCCCCCCCHHE | 35.40 | 23749301 | |
| 48 | Phosphorylation | NVTSPTKSVSCISQA CCCCCCCCCCHHEEC | 23.03 | 23749301 | |
| 50 | Phosphorylation | TSPTKSVSCISQAEN CCCCCCCCHHEECCC | 16.90 | 28889911 | |
| 53 | Phosphorylation | TKSVSCISQAENGVA CCCCCHHEECCCCCC | 27.89 | 23749301 | |
| 343 | Phosphorylation | KDSNSIKSGDSNSQS CCCCCCCCCCCCCCC | 46.27 | 22369663 | |
| 346 | Phosphorylation | NSIKSGDSNSQSNNM CCCCCCCCCCCCCCC | 41.74 | 22369663 | |
| 348 | Phosphorylation | IKSGDSNSQSNNMSH CCCCCCCCCCCCCCC | 38.65 | 22369663 | |
| 350 | Phosphorylation | SGDSNSQSNNMSHFN CCCCCCCCCCCCCCC | 29.96 | 22369663 | |
| 354 | Phosphorylation | NSQSNNMSHFNPTTN CCCCCCCCCCCCCCC | 27.35 | 22369663 | |
| 367 | Phosphorylation | TNIGSLLSSAASSFR CCHHHHHHHHHHHCC | 24.19 | 21079247 | |
| 368 | Phosphorylation | NIGSLLSSAASSFRG CHHHHHHHHHHHCCC | 28.02 | 21079247 | |
| 371 | Phosphorylation | SLLSSAASSFRGTPD HHHHHHHHHCCCCCC | 29.71 | 21079247 | |
| 372 | Phosphorylation | LLSSAASSFRGTPDK HHHHHHHHCCCCCCC | 17.78 | 21079247 | |
| 376 | Phosphorylation | AASSFRGTPDKKVEL HHHHCCCCCCCCEEE | 24.86 | 21551504 | |
| 491 | Phosphorylation | TPEYYLISSNDAIRV CCCEEEECCCCCEEE | 22.09 | 27017623 | |
| 665 | Ubiquitination | SEPTASSKEEGSNIT HCCCCCCCCCCCCCE | 58.24 | 23749301 | |
| 735 | Phosphorylation | KGEISHISKLSIFEI CCCCCHHCEEEEEEE | 23.32 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS41_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS41_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS41_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-44; SER-48;SER-53 AND SER-343, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, AND MASSSPECTROMETRY. | |
