AYR1_YEAST - dbPTM
AYR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AYR1_YEAST
UniProt AC P40471
Protein Name NADPH-dependent 1-acyldihydroxyacetone phosphate reductase
Gene Name AYR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 297
Subcellular Localization Lipid droplet. Endoplasmic reticulum.
Protein Description Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination..
Protein Sequence MSELQSQPKKIAVVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGNDSIKPYKLDISKPEEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAAVEQCFKVNVFGHINMCRELSEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVINAITGGVATDIADKRPLPETSIYNFPEGREAFNSRKTMAKDNKPMPADAYAKQLVKDILSTSDPVDVYRGTFANIMRFVMIFVPYWLLEKGLSKKFKLDKVNNALKSKQKNKDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9UbiquitinationSELQSQPKKIAVVTG
HHHHCCCCEEEEEEC		49.5317644757
10UbiquitinationELQSQPKKIAVVTGA
HHHCCCCEEEEEECC		42.4517644757
27UbiquitinationGIGYEVTKELARNGY
CCCHHHHHHHHHCCC		56.7717644757
134AcetylationELSEFLIKAKGTIVF
HHHHHHHHCCCEEEE		46.3124489116
176AcetylationRGLHLEMKPFNVRVI
CCCCCEECCCCCEEE		36.7624489116
176UbiquitinationRGLHLEMKPFNVRVI
CCCCCEECCCCCEEE		36.7624961812
197AcetylationVATDIADKRPLPETS
CCCCCCCCCCCCCCC		47.0624489116
197UbiquitinationVATDIADKRPLPETS
CCCCCCCCCCCCCCC		47.0617644757
226UbiquitinationKTMAKDNKPMPADAY
CCCCCCCCCCCHHHH		53.4823749301
235AcetylationMPADAYAKQLVKDIL
CCHHHHHHHHHHHHH		31.3324489116
235UbiquitinationMPADAYAKQLVKDIL
CCHHHHHHHHHHHHH		31.3322817900
239AcetylationAYAKQLVKDILSTSD
HHHHHHHHHHHHCCC		47.8724489116
239UbiquitinationAYAKQLVKDILSTSD
HHHHHHHHHHHHCCC		47.8723749301
243PhosphorylationQLVKDILSTSDPVDV
HHHHHHHHCCCCCHH		26.6328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AYR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AYR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AYR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PMA1_YEASTPMA1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
TGL1_YEASTTGL1physical
18467557
OSTD_YEASTSWP1physical
18467557
PIS_YEASTPIS1physical
18467557
SNA3_YEASTSNA3physical
18467557
GST1_YEASTGTT1physical
18719252
HSP7F_YEASTSSE1physical
19536198
GPD1_YEASTGPD1genetic
21623372
ERG2_YEASTERG2genetic
21623372
ELO2_YEASTELO2genetic
21623372
TNA1_YEASTTNA1genetic
21623372
AYR1_YEASTAYR1physical
22940862
HSP71_YEASTSSA1physical
22940862
PHO88_YEASTPHO88genetic
23891562
SCH9_YEASTSCH9genetic
23891562
SHG1_YEASTSHG1genetic
27708008
ATG15_YEASTATG15genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
ARX1_YEASTARX1genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
AIM18_YEASTAIM18genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
PET8_YEASTPET8genetic
27708008
MKT1_YEASTMKT1genetic
27708008
INO4_YEASTINO4genetic
27708008
RPB2_YEASTRPB2genetic
27708008
TOA1_YEASTTOA1genetic
27708008
ARP7_YEASTARP7genetic
27708008
GPT1_YEASTSCT1genetic
27708008
STE50_YEASTSTE50genetic
27708008
RIM1_YEASTRIM1genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
RV167_YEASTRVS167genetic
27708008
GEP7_YEASTGEP7genetic
27708008
ATG1_YEASTATG1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
KC11_YEASTYCK1genetic
27708008
NCA3_YEASTNCA3genetic
27708008
TRK2_YEASTTRK2genetic
27708008
RL1D1_YEASTUTP30genetic
27708008
COA4_YEASTCOA4genetic
27708008
COX7_YEASTCOX7genetic
27708008
OCA1_YEASTOCA1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
HMI1_YEASTHMI1genetic
27708008
YORA4_YEASTYOR114Wgenetic
27708008
PMA2_YEASTPMA2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
VPS4_YEASTVPS4genetic
27708008
CR3L1_HUMANCREB3L1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AYR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.

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