TNA1_YEAST - dbPTM
TNA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNA1_YEAST
UniProt AC P53322
Protein Name High-affinity nicotinic acid transporter
Gene Name TNA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 534
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Involved in the uptake of nicotinic acid..
Protein Sequence MSNKFTMESPKHLVDDVLFISPTNDGSEEKPTEVTFQEDEGHDASLHNRSHDKKSELATEREIMATTTDDDGIPSPSHPMEKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSKDIHLVGTQYNTCVTVFFATYVLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWVKNYAQLIVVRLLLGAFEGMIYPAINMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCSKISGSLKDWQYIYIVEGCISLGFVPFYAFGLSKNLEDSWFFNKEEKEYISERYKTMNTFDPDEKFEWFQVWQAVKDVKTWASAVALFGIDLTTFGLTVFLPIIITSMGFTNVRAQLMTVPIYFLTAIVFFICAVWSDRIKLRSPFILGACLTTSIGIAIVLGSQVHGVRYFGVYILCMGIYVNAACNCLWLSGNTGNYFKRATALGINLFFGSGSGLVSGQIFVAKDKPRYIKGLSISLAFQVFSIFMTVVQIFLYKRENDKKKAIIDRCNELGEPIPYDERLSDKNPEFKYMY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNKFTMES
------CCCCCCCCC		49.0422369663
6Phosphorylation--MSNKFTMESPKHL
--CCCCCCCCCCCCC		22.9522369663
9PhosphorylationSNKFTMESPKHLVDD
CCCCCCCCCCCCCCE		28.5522369663
21PhosphorylationVDDVLFISPTNDGSE
CCEEEEEECCCCCCC		20.5219779198
23PhosphorylationDVLFISPTNDGSEEK
EEEEEECCCCCCCCC		38.8719779198
27PhosphorylationISPTNDGSEEKPTEV
EECCCCCCCCCCCEE		45.5028889911
32PhosphorylationDGSEEKPTEVTFQED
CCCCCCCCEEEEECC		54.9028889911
35PhosphorylationEEKPTEVTFQEDEGH
CCCCCEEEEECCCCC		17.2319779198
45PhosphorylationEDEGHDASLHNRSHD
CCCCCCCCCCCCCCC		35.9028889911
50PhosphorylationDASLHNRSHDKKSEL
CCCCCCCCCCHHHHH		41.1624961812
53UbiquitinationLHNRSHDKKSELATE
CCCCCCCHHHHHHHH		53.4224961812
54UbiquitinationHNRSHDKKSELATER
CCCCCCHHHHHHHHC		56.0423749301
55PhosphorylationNRSHDKKSELATERE
CCCCCHHHHHHHHCH		43.5124930733
66PhosphorylationTEREIMATTTDDDGI
HHCHHHCCCCCCCCC		16.9122369663
67PhosphorylationEREIMATTTDDDGIP
HCHHHCCCCCCCCCC		20.7722369663
68PhosphorylationREIMATTTDDDGIPS
CHHHCCCCCCCCCCC		32.8322369663
75PhosphorylationTDDDGIPSPSHPMEK
CCCCCCCCCCCHHHH		36.7922369663
77PhosphorylationDDGIPSPSHPMEKRV
CCCCCCCCCHHHHHH		44.5622369663
91PhosphorylationVLRKMDIYLIPLMGM
HHHHCCHHHHHHHHH		8.3628889911
283UbiquitinationEDSWFFNKEEKEYIS
HHCCCCCHHHHHHHH		63.1924961812
531UbiquitinationSDKNPEFKYMY----
CCCCCCCCCCC----		27.6923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEO1_YEASTSEO1physical
16093310
MST28_YEASTMST28physical
16093310
MNN2_YEASTMNN2physical
16093310
PHO88_YEASTPHO88physical
16093310
MKAR_YEASTIFA38physical
16093310
VBA2_YEASTVBA2physical
16093310
PBN1_YEASTPBN1physical
16093310
ELO2_YEASTELO2physical
16093310
SHR3_YEASTSHR3physical
16093310
OST4_YEASTOST4physical
16093310
SUR2_YEASTSUR2physical
16093310
FET5_YEASTFET5physical
16093310
MST27_YEASTMST27physical
16093310
ERV29_YEASTERV29physical
16093310
VATO_YEASTVMA16physical
16093310
YHK8_YEASTYHK8physical
16093310
ERP5_YEASTERP5physical
16093310
CHS7_YEASTCHS7physical
16093310
SNL1_YEASTSNL1physical
16093310
SYG1_YEASTSYG1physical
16093310
PHO86_YEASTPHO86physical
16093310
ELO1_YEASTELO1physical
16093310
STE24_YEASTSTE24physical
16093310
LAC1_YEASTLAC1physical
16093310
YET1_YEASTYET1physical
16093310
SRPB_YEASTSRP102physical
16093310
MRS4_YEASTMRS4physical
16093310
ELO3_YEASTELO3physical
16093310
GSF2_YEASTGSF2physical
16093310
HMDH1_YEASTHMG1physical
16093310
IMP1_YEASTIMP1physical
16093310
PT111_YEASTPET111physical
16093310
DYN3_YEASTDYN3physical
16093310
PRA1_YEASTYIP3physical
16093310
ERP4_YEASTERP4physical
16093310
VTC3_YEASTVTC3physical
16093310
GPI2_YEASTGPI2physical
16093310
YOP1_YEASTYOP1physical
16093310
SRS2_YEASTSRS2genetic
21459050
3HAO_YEASTBNA1genetic
21623372
NADC_YEASTBNA6genetic
21623372
I23O_YEASTBNA2genetic
21623372
KMO_YEASTBNA4genetic
21623372
PUR7_YEASTADE1genetic
21623372
KYNU_YEASTBNA5genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
PDX3_YEASTPDX3genetic
21623372
FOLE_YEASTMET7genetic
21623372
OAT_YEASTCAR2genetic
21623372
6PGD1_YEASTGND1genetic
21623372
MNN10_YEASTMNN10genetic
27708008
AAKG_YEASTSNF4genetic
27708008
BRE2_YEASTBRE2genetic
27708008
RTG3_YEASTRTG3genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
YD012_YEASTYDL012Cgenetic
27708008
TPS2_YEASTTPS2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
UME6_YEASTUME6genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
XRS2_YEASTXRS2genetic
27708008
KFA_YEASTBNA7genetic
27708008
STL1_YEASTSTL1genetic
27708008
RAD51_YEASTRAD51genetic
27708008
DLDH_YEASTLPD1genetic
27708008
NADC_YEASTBNA6genetic
27708008
HXKB_YEASTHXK2genetic
27708008
PTH_YEASTPTH1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
BZRD_YEASTIRC24genetic
27708008
3HAO_YEASTBNA1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
I23O_YEASTBNA2genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
KYNU_YEASTBNA5genetic
27708008
MMS22_YEASTMMS22genetic
27708008
VAC14_YEASTVAC14genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
MSS1_YEASTMSS1genetic
27708008
YMY9_YEASTYMR099Cgenetic
27708008
YNB0_YEASTYNL010Wgenetic
27708008
SWS2_YEASTSWS2genetic
27708008
YN94_YEASTYNR065Cgenetic
27708008
DIA2_YEASTDIA2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNA1_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-283, AND MASSSPECTROMETRY.

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