ELO1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELO1_YEAST
• UniProt AC: P39540
• Protein Name: Elongation of fatty acids protein 1 {ECO:0000303|PubMed:8702485}
• Gene Name: ELO1 {ECO:0000303|PubMed:8702485}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 310
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids. Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA..
• Protein Sequence: MVSDWKNFCLEKASRFRPTIDRPFFNIYLWDYFNRAVGWATAGRFQPKDFEFTVGKQPLSEPRPVLLFIAMYYVVIFGGRSLVKSCKPLKLRFISQVHNLMLTSVSFLWLILMVEQMLPIVYRHGLYFAVCNVESWTQPMETLYYLNYMTKFVEFADTVLMVLKHRKLTFLHTYHHGATALLCYNQLVGYTAVTWVPVTLNLAVHVLMYWYYFLSASGIRVWWKAWVTRLQIVQFMLDLIVVYYVLYQKIVAAYFKNACTPQCEDCLGSMTAIAAGAAILTSYLFLFISFYIEVYKRGSASGKKKINKNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	WKNFCLEKASRFRPT HHHHHHHHHHCCCCC	38.42	22865919
48	Acetylation	TAGRFQPKDFEFTVG CCCCCCCCCEEEEEC	65.35	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELO1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELO1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELO1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EMC1_YEAST	EMC1	genetic	16269340
ORM2_YEAST	ORM2	genetic	16269340
GET1_YEAST	GET1	genetic	16269340
PLMT_YEAST	OPI3	genetic	16269340
RLA4_YEAST	RPP2B	genetic	20093466
RTR1_YEAST	RTR1	genetic	20093466
XRN1_YEAST	XRN1	genetic	20093466
MON1_YEAST	MON1	genetic	20093466
PEX1_YEAST	PEX1	genetic	20093466
KTI12_YEAST	KTI12	genetic	20093466
DBP7_YEAST	DBP7	genetic	20093466
VRP1_YEAST	VRP1	genetic	20093466
AIM32_YEAST	AIM32	genetic	20093466
RSF1_YEAST	RSF1	genetic	20093466
MRE11_YEAST	MRE11	genetic	20093466
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
SUR2_YEAST	SUR2	physical	16093310
PRM8_YEAST	PRM8	physical	16093310
ERP5_YEAST	ERP5	physical	16093310
YHU0_YEAST	YHR140W	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
ATC7_YEAST	NEO1	physical	16093310
STE24_YEAST	STE24	physical	16093310
YET1_YEAST	YET1	physical	16093310
SRPB_YEAST	SRP102	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
PRA1_YEAST	YIP3	physical	16093310
ALG5_YEAST	ALG5	physical	16093310
YOP1_YEAST	YOP1	physical	16093310
ELO1_YEAST	ELO1	physical	16093310
CBS_YEAST	CYS4	genetic	21623372
DED1_YEAST	DED1	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
ARV1_YEAST	ARV1	genetic	23891562
CSG2_YEAST	CSG2	genetic	23891562
STE50_YEAST	STE50	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
CP56_YEAST	DIT2	genetic	27708008
RTR1_YEAST	RTR1	genetic	27708008
ODPA_YEAST	PDA1	genetic	27708008
KTI12_YEAST	KTI12	genetic	27708008
SST2_YEAST	SST2	genetic	27708008
AIM32_YEAST	AIM32	genetic	27708008
MSC1_YEAST	MSC1	genetic	27708008
RAS2_YEAST	RAS2	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.