| UniProt ID | CBS_YEAST | |
|---|---|---|
| UniProt AC | P32582 | |
| Protein Name | Cystathionine beta-synthase | |
| Gene Name | CYS4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 507 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MTKSEQQADSRHNVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIVGADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWDDDVLARFDSSKLEASTTKYADVFGNATVKDLHLKPVVSVKETAKVTDVIKILKDNGFDQLPVLTEDGKLSGLVTLSELLRKLSINNSNNDNTIKGKYLDFKKLNNFNDVSSYNENKSGKKKFIKFDENSKLSDLNRFFEKNSSAVITDGLKPIHIVTKMDLLSYLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTKSEQQAD ------CCHHHHHHH | 43.19 | 19823750 | |
| 4 | Phosphorylation | ----MTKSEQQADSR ----CCHHHHHHHHC | 31.32 | 24961812 | |
| 10 | Phosphorylation | KSEQQADSRHNVIDL HHHHHHHHCCCCCHH | 38.15 | 21440633 | |
| 27 | Acetylation | NTPLIALKKLPKALG CCHHHHHHHHHHHCC | 43.15 | 24489116 | |
| 27 | Succinylation | NTPLIALKKLPKALG CCHHHHHHHHHHHCC | 43.15 | 23954790 | |
| 27 | Ubiquitination | NTPLIALKKLPKALG CCHHHHHHHHHHHCC | 43.15 | 17644757 | |
| 28 | Ubiquitination | TPLIALKKLPKALGI CHHHHHHHHHHHCCC | 71.52 | 17644757 | |
| 31 | Ubiquitination | IALKKLPKALGIKPQ HHHHHHHHHCCCCCE | 67.68 | 17644757 | |
| 36 | Acetylation | LPKALGIKPQIYAKL HHHHCCCCCEEEEEE | 29.13 | 24489116 | |
| 36 | Ubiquitination | LPKALGIKPQIYAKL HHHHCCCCCEEEEEE | 29.13 | 17644757 | |
| 42 | Acetylation | IKPQIYAKLELYNPG CCCEEEEEEEEECCC | 26.06 | 24489116 | |
| 42 | Ubiquitination | IKPQIYAKLELYNPG CCCEEEEEEEEECCC | 26.06 | 17644757 | |
| 51 | Phosphorylation | ELYNPGGSIKDRIAK EEECCCCCHHHHHHH | 32.17 | 21440633 | |
| 53 | N6-(pyridoxal phosphate)lysine | YNPGGSIKDRIAKSM ECCCCCHHHHHHHHH | 42.52 | - | |
| 53 | Acetylation | YNPGGSIKDRIAKSM ECCCCCHHHHHHHHH | 42.52 | 24489116 | |
| 53 | Other | YNPGGSIKDRIAKSM ECCCCCHHHHHHHHH | 42.52 | - | |
| 53 | Succinylation | YNPGGSIKDRIAKSM ECCCCCHHHHHHHHH | 42.52 | 23954790 | |
| 53 | Ubiquitination | YNPGGSIKDRIAKSM ECCCCCHHHHHHHHH | 42.52 | 23749301 | |
| 58 | Ubiquitination | SIKDRIAKSMVEEAE CHHHHHHHHHHHHHH | 36.39 | 23749301 | |
| 59 | Phosphorylation | IKDRIAKSMVEEAEA HHHHHHHHHHHHHHH | 21.02 | 28889911 | |
| 96 | Ubiquitination | LALIGAIKGYRTIIT HHHHHHHCCCEEEEE | 49.72 | 23749301 | |
| 107 | Acetylation | TIITLPEKMSNEKVS EEEECCHHHCCCCHH | 45.77 | 24489116 | |
| 109 | Phosphorylation | ITLPEKMSNEKVSVL EECCHHHCCCCHHHH | 53.56 | 28152593 | |
| 112 | Ubiquitination | PEKMSNEKVSVLKAL CHHHCCCCHHHHHHH | 44.02 | 23749301 | |
| 117 | Acetylation | NEKVSVLKALGAEII CCCHHHHHHHCCCHH | 39.13 | 24489116 | |
| 117 | Ubiquitination | NEKVSVLKALGAEII CCCHHHHHHHCCCHH | 39.13 | 23749301 | |
| 126 | Phosphorylation | LGAEIIRTPTAAAWD HCCCHHCCCCCCCCC | 18.00 | 17330950 | |
| 128 | Phosphorylation | AEIIRTPTAAAWDSP CCHHCCCCCCCCCCC | 28.46 | 25752575 | |
| 134 | Phosphorylation | PTAAAWDSPESHIGV CCCCCCCCCCHHHHH | 21.62 | 21082442 | |
| 137 | Phosphorylation | AAWDSPESHIGVAKK CCCCCCCHHHHHHHH | 24.64 | 20377248 | |
| 143 | Acetylation | ESHIGVAKKLEKEIP CHHHHHHHHHHCCCC | 56.32 | 24489116 | |
| 143 | Ubiquitination | ESHIGVAKKLEKEIP CHHHHHHHHHHCCCC | 56.32 | 17644757 | |
| 144 | Acetylation | SHIGVAKKLEKEIPG HHHHHHHHHHCCCCC | 52.74 | 24489116 | |
| 144 | Ubiquitination | SHIGVAKKLEKEIPG HHHHHHHHHHCCCCC | 52.74 | 17644757 | |
| 147 | Acetylation | GVAKKLEKEIPGAVI HHHHHHHCCCCCEEE | 71.96 | 24489116 | |
| 197 | Phosphorylation | AVVAGAGTGGTISGI HHHCCCCCCHHHHHH | 31.72 | 22369663 | |
| 200 | Phosphorylation | AGAGTGGTISGISKY CCCCCCHHHHHHHHH | 17.20 | 22369663 | |
| 202 | Phosphorylation | AGTGGTISGISKYLK CCCCHHHHHHHHHHH | 29.88 | 22369663 | |
| 205 | Phosphorylation | GGTISGISKYLKEQN CHHHHHHHHHHHHCC | 20.83 | 22369663 | |
| 206 | Acetylation | GTISGISKYLKEQND HHHHHHHHHHHHCCC | 53.32 | 24489116 | |
| 207 | Phosphorylation | TISGISKYLKEQNDK HHHHHHHHHHHCCCC | 19.06 | 28132839 | |
| 209 | 2-Hydroxyisobutyrylation | SGISKYLKEQNDKIQ HHHHHHHHHCCCCEE | 54.91 | - | |
| 209 | Succinylation | SGISKYLKEQNDKIQ HHHHHHHHHCCCCEE | 54.91 | 23954790 | |
| 214 | Acetylation | YLKEQNDKIQIVGAD HHHHCCCCEEEEEEC | 44.02 | 24489116 | |
| 235 | Ubiquitination | AQPENLNKTDITDYK CCCCCCCCCCCCCCE | 51.22 | 18433149 | |
| 242 | Acetylation | KTDITDYKVEGIGYD CCCCCCCEEECCCCC | 36.30 | 24489116 | |
| 258 | Acetylation | VPQVLDRKLIDVWYK HHHHHCHHHEEEEEE | 49.84 | 24489116 | |
| 265 | Acetylation | KLIDVWYKTDDKPSF HHEEEEEECCCCCCH | 29.75 | 24489116 | |
| 269 | Ubiquitination | VWYKTDDKPSFKYAR EEEECCCCCCHHHHH | 45.42 | 22817900 | |
| 273 | Acetylation | TDDKPSFKYARQLIS CCCCCCHHHHHHHHH | 42.19 | 22865919 | |
| 273 | Ubiquitination | TDDKPSFKYARQLIS CCCCCCHHHHHHHHH | 42.19 | 22817900 | |
| 280 | Phosphorylation | KYARQLISNEGVLVG HHHHHHHHCCCEEEC | 37.10 | 22369663 | |
| 289 | Phosphorylation | EGVLVGGSSGSAFTA CCEEECCCCCHHHHH | 26.12 | 22369663 | |
| 290 | Phosphorylation | GVLVGGSSGSAFTAV CEEECCCCCHHHHHH | 39.79 | 22369663 | |
| 292 | Phosphorylation | LVGGSSGSAFTAVVK EECCCCCHHHHHHHH | 23.35 | 22369663 | |
| 295 | Phosphorylation | GSSGSAFTAVVKYCE CCCCHHHHHHHHHHC | 20.47 | 22369663 | |
| 327 | Acetylation | SIRSYLTKFVDDEWL HHHHHHHHHCCHHHH | 40.57 | 24489116 | |
| 327 | Ubiquitination | SIRSYLTKFVDDEWL HHHHHHHHHCCHHHH | 40.57 | 23749301 | |
| 335 | 2-Hydroxyisobutyrylation | FVDDEWLKKNNLWDD HCCHHHHHHCCCCCH | 55.30 | - | |
| 335 | Acetylation | FVDDEWLKKNNLWDD HCCHHHHHHCCCCCH | 55.30 | 22865919 | |
| 335 | Succinylation | FVDDEWLKKNNLWDD HCCHHHHHHCCCCCH | 55.30 | 23954790 | |
| 335 | Ubiquitination | FVDDEWLKKNNLWDD HCCHHHHHHCCCCCH | 55.30 | 17644757 | |
| 336 | 2-Hydroxyisobutyrylation | VDDEWLKKNNLWDDD CCHHHHHHCCCCCHH | 49.23 | - | |
| 336 | Ubiquitination | VDDEWLKKNNLWDDD CCHHHHHHCCCCCHH | 49.23 | 17644757 | |
| 350 | Phosphorylation | DVLARFDSSKLEAST HHHHHCCHHHCCCCC | 27.02 | 22369663 | |
| 351 | Phosphorylation | VLARFDSSKLEASTT HHHHCCHHHCCCCCC | 43.00 | 22369663 | |
| 352 | 2-Hydroxyisobutyrylation | LARFDSSKLEASTTK HHHCCHHHCCCCCCC | 55.06 | - | |
| 352 | Acetylation | LARFDSSKLEASTTK HHHCCHHHCCCCCCC | 55.06 | 24489116 | |
| 356 | Phosphorylation | DSSKLEASTTKYADV CHHHCCCCCCCCHHH | 27.51 | 22369663 | |
| 357 | Phosphorylation | SSKLEASTTKYADVF HHHCCCCCCCCHHHH | 34.06 | 22369663 | |
| 358 | Phosphorylation | SKLEASTTKYADVFG HHCCCCCCCCHHHHC | 21.40 | 22369663 | |
| 359 | Acetylation | KLEASTTKYADVFGN HCCCCCCCCHHHHCC | 38.23 | 24489116 | |
| 359 | Ubiquitination | KLEASTTKYADVFGN HCCCCCCCCHHHHCC | 38.23 | 23749301 | |
| 360 | Phosphorylation | LEASTTKYADVFGNA CCCCCCCCHHHHCCC | 13.12 | 19779198 | |
| 370 | Acetylation | VFGNATVKDLHLKPV HHCCCEEEECCCCCC | 50.66 | 24489116 | |
| 375 | Acetylation | TVKDLHLKPVVSVKE EEEECCCCCCEEHHC | 25.64 | 24489116 | |
| 379 | Phosphorylation | LHLKPVVSVKETAKV CCCCCCEEHHCEEEC | 27.92 | 21440633 | |
| 381 | 2-Hydroxyisobutyrylation | LKPVVSVKETAKVTD CCCCEEHHCEEECCH | 41.67 | - | |
| 385 | 2-Hydroxyisobutyrylation | VSVKETAKVTDVIKI EEHHCEEECCHHHHH | 53.76 | - | |
| 391 | 2-Hydroxyisobutyrylation | AKVTDVIKILKDNGF EECCHHHHHHHHCCC | 41.66 | - | |
| 391 | Acetylation | AKVTDVIKILKDNGF EECCHHHHHHHHCCC | 41.66 | 24489116 | |
| 394 | Acetylation | TDVIKILKDNGFDQL CHHHHHHHHCCCCCC | 53.25 | 24489116 | |
| 405 | Phosphorylation | FDQLPVLTEDGKLSG CCCCCEECCCCCEEC | 32.06 | 24961812 | |
| 411 | Phosphorylation | LTEDGKLSGLVTLSE ECCCCCEECEEEHHH | 33.30 | 24961812 | |
| 415 | Phosphorylation | GKLSGLVTLSELLRK CCEECEEEHHHHHHH | 29.61 | 19779198 | |
| 417 | Phosphorylation | LSGLVTLSELLRKLS EECEEEHHHHHHHHC | 19.48 | 19779198 | |
| 422 | Ubiquitination | TLSELLRKLSINNSN EHHHHHHHHCCCCCC | 46.70 | 23749301 | |
| 424 | Phosphorylation | SELLRKLSINNSNND HHHHHHHCCCCCCCC | 26.72 | 22369663 | |
| 428 | Phosphorylation | RKLSINNSNNDNTIK HHHCCCCCCCCCCCC | 32.30 | 22369663 | |
| 433 | Phosphorylation | NNSNNDNTIKGKYLD CCCCCCCCCCCCCCC | 27.25 | 22369663 | |
| 435 | Ubiquitination | SNNDNTIKGKYLDFK CCCCCCCCCCCCCHH | 47.51 | 17644757 | |
| 437 | Acetylation | NDNTIKGKYLDFKKL CCCCCCCCCCCHHHC | 37.32 | 24489116 | |
| 442 | Ubiquitination | KGKYLDFKKLNNFND CCCCCCHHHCCCCCC | 56.89 | 17644757 | |
| 443 | Ubiquitination | GKYLDFKKLNNFNDV CCCCCHHHCCCCCCC | 57.34 | 23749301 | |
| 451 | Phosphorylation | LNNFNDVSSYNENKS CCCCCCCCCCCCCCC | 29.93 | 22369663 | |
| 452 | Phosphorylation | NNFNDVSSYNENKSG CCCCCCCCCCCCCCC | 31.65 | 22369663 | |
| 453 | Phosphorylation | NFNDVSSYNENKSGK CCCCCCCCCCCCCCC | 20.99 | 21440633 | |
| 457 | Acetylation | VSSYNENKSGKKKFI CCCCCCCCCCCCEEE | 55.17 | 24489116 | |
| 457 | Ubiquitination | VSSYNENKSGKKKFI CCCCCCCCCCCCEEE | 55.17 | 17644757 | |
| 465 | Acetylation | SGKKKFIKFDENSKL CCCCEEEECCCCCCH | 50.31 | 24489116 | |
| 470 | Phosphorylation | FIKFDENSKLSDLNR EEECCCCCCHHHHHH | 32.69 | 30377154 | |
| 471 | Acetylation | IKFDENSKLSDLNRF EECCCCCCHHHHHHH | 64.69 | 24489116 | |
| 473 | Phosphorylation | FDENSKLSDLNRFFE CCCCCCHHHHHHHHH | 43.73 | 30377154 | |
| 481 | Acetylation | DLNRFFEKNSSAVIT HHHHHHHHCCCCEEC | 57.90 | 24489116 | |
| 481 | Ubiquitination | DLNRFFEKNSSAVIT HHHHHHHHCCCCEEC | 57.90 | 17644757 | |
| 483 | Phosphorylation | NRFFEKNSSAVITDG HHHHHHCCCCEECCC | 30.64 | 28889911 | |
| 492 | Acetylation | AVITDGLKPIHIVTK CEECCCCCEEEEEEH | 47.67 | 24489116 | |
| 492 | Ubiquitination | AVITDGLKPIHIVTK CEECCCCCEEEEEEH | 47.67 | 17644757 | |
| 498 | Phosphorylation | LKPIHIVTKMDLLSY CCEEEEEEHHHHHHH | 21.76 | 28889911 | |
| 499 | Ubiquitination | KPIHIVTKMDLLSYL CEEEEEEHHHHHHHH | 21.37 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CBS_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CBS_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CBS_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-128; SER-134; SER-350AND SER-424, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350, AND MASSSPECTROMETRY. | |
