| UniProt ID | SNF1_YEAST | |
|---|---|---|
| UniProt AC | P06782 | |
| Protein Name | Carbon catabolite-derepressing protein kinase {ECO:0000303|PubMed:3526554} | |
| Gene Name | SNF1 {ECO:0000303|PubMed:6366512} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 633 | |
| Subcellular Localization |
Cytoplasm . Nucleus . Nucleus membrane Peripheral membrane protein . Nuclear translocation occurs under nitrogen and glucose starvation conditions (PubMed:25869125). |
|
| Protein Description | Serine/threonine protein kinase essential for release from glucose repression. [PubMed: 3526554] | |
| Protein Sequence | MSSNNNTNTAPANANSSHHHHHHHHHHHHHGHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPAFNEIRDAYMLIKENKSLIKDMKANKSVSDELDTFLSQSPPTFQQQSKSHQKSQVDHETAKQHARRMASAITQQRTYHQSPFMDQYKEEDSTVSILPTSLPQIHRANMLAQGSPAASKISPLVTKKSKTRWHFGIRSRSYPLDVMGEIYIALKNLGAEWAKPSEEDLWTIKLRWKYDIGNKTNTNEKIPDLMKMVIQLFQIETNNYLVDFKFDGWESSYGDDTTVSNISEDEMSTFSAYPFLHLTTKLIMELAVNSQSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | Ubiquitination | NSTLNNPKSSLADGA CCCCCCCHHHCCCCC | 55.59 | 17644757 | |
| 44 | Phosphorylation | STLNNPKSSLADGAH CCCCCCHHHCCCCCE | 31.66 | 21551504 | |
| 45 | Phosphorylation | TLNNPKSSLADGAHI CCCCCHHHCCCCCEE | 33.43 | 27017623 | |
| 59 | Acetylation | IGNYQIVKTLGEGSF ECCEEEEEEECCCCC | 39.39 | 24489116 | |
| 59 | Ubiquitination | IGNYQIVKTLGEGSF ECCEEEEEEECCCCC | 39.39 | 17644757 | |
| 60 | Phosphorylation | GNYQIVKTLGEGSFG CCEEEEEEECCCCCC | 29.15 | 23749301 | |
| 68 | Acetylation | LGEGSFGKVKLAYHT ECCCCCCEEEEEEEC | 33.90 | 22865919 | |
| 68 | Ubiquitination | LGEGSFGKVKLAYHT ECCCCCCEEEEEEEC | 33.90 | 17644757 | |
| 70 | Ubiquitination | EGSFGKVKLAYHTTT CCCCCEEEEEEECCC | 30.77 | 17644757 | |
| 80 | Ubiquitination | YHTTTGQKVALKIIN EECCCCCEEHHHHHC | 30.71 | 23749301 | |
| 84 | Ubiquitination | TGQKVALKIINKKVL CCCEEHHHHHCHHHH | 31.63 | 22817900 | |
| 148 | Ubiquitination | DYIVQRDKMSEQEAR HHHHHHHCCCHHHHH | 46.65 | 23749301 | |
| 179 | Ubiquitination | KIVHRDLKPENLLLD CCCCCCCCHHHCCCC | 55.35 | 17644757 | |
| 192 | Ubiquitination | LDEHLNVKIADFGLS CCCCCCEEEHHHCCC | 30.97 | 17644757 | |
| 199 | Phosphorylation | KIADFGLSNIMTDGN EEHHHCCCCCCCCCC | 25.37 | 21440633 | |
| 203 | Phosphorylation | FGLSNIMTDGNFLKT HCCCCCCCCCCCCCC | 36.64 | 23749301 | |
| 209 | Ubiquitination | MTDGNFLKTSCGSPN CCCCCCCCCCCCCCC | 33.96 | 23749301 | |
| 210 | Phosphorylation | TDGNFLKTSCGSPNY CCCCCCCCCCCCCCC | 31.25 | 22369663 | |
| 211 | Phosphorylation | DGNFLKTSCGSPNYA CCCCCCCCCCCCCCC | 18.20 | 22369663 | |
| 214 | Phosphorylation | FLKTSCGSPNYAAPE CCCCCCCCCCCCCCH | 17.82 | 22890988 | |
| 217 | Phosphorylation | TSCGSPNYAAPEVIS CCCCCCCCCCCHHHC | 13.92 | 22890988 | |
| 224 | Phosphorylation | YAAPEVISGKLYAGP CCCCHHHCCCCCCCC | 34.74 | 22890988 | |
| 226 | Ubiquitination | APEVISGKLYAGPEV CCHHHCCCCCCCCCC | 31.37 | 17644757 | |
| 256 | Phosphorylation | RLPFDDESIPVLFKN CCCCCCCCCCEEEEE | 38.90 | 23749301 | |
| 262 | Ubiquitination | ESIPVLFKNISNGVY CCCCEEEEECCCCCC | 49.57 | 17644757 | |
| 273 | Ubiquitination | NGVYTLPKFLSPGAA CCCCCCHHHCCCCHH | 63.15 | 17644757 | |
| 273 | Acetylation | NGVYTLPKFLSPGAA CCCCCCHHHCCCCHH | 63.15 | 24489116 | |
| 284 | Ubiquitination | PGAAGLIKRMLIVNP CCHHHHHHHHHCCCC | 36.48 | 24961812 | |
| 284 | Acetylation | PGAAGLIKRMLIVNP CCHHHHHHHHHCCCC | 36.48 | 24489116 | |
| 338 | Phosphorylation | DSKKDGSSPDNDEID CCCCCCCCCCCHHHH | 41.63 | 27214570 | |
| 360 | Ubiquitination | SSTMGYEKDEIYESL HHHCCCCHHHHHHHH | 52.78 | 19722269 | |
| 364 | Phosphorylation | GYEKDEIYESLESSE CCCHHHHHHHHHCCC | 9.45 | 23749301 | |
| 373 | Phosphorylation | SLESSEDTPAFNEIR HHHCCCCCHHHHHHH | 16.68 | 23749301 | |
| 383 | Phosphorylation | FNEIRDAYMLIKENK HHHHHHHHHHHHHCH | 9.20 | 23749301 | |
| 400 | Ubiquitination | IKDMKANKSVSDELD HHHHHCCCCHHHHHH | 58.03 | 17644757 | |
| 401 | Phosphorylation | KDMKANKSVSDELDT HHHHCCCCHHHHHHH | 27.02 | 22369663 | |
| 403 | Phosphorylation | MKANKSVSDELDTFL HHCCCCHHHHHHHHH | 32.24 | 20377248 | |
| 408 | Phosphorylation | SVSDELDTFLSQSPP CHHHHHHHHHHCCCC | 38.82 | 22369663 | |
| 411 | Phosphorylation | DELDTFLSQSPPTFQ HHHHHHHHCCCCCHH | 25.15 | 25521595 | |
| 413 | Phosphorylation | LDTFLSQSPPTFQQQ HHHHHHCCCCCHHHH | 29.48 | 22369663 | |
| 416 | Phosphorylation | FLSQSPPTFQQQSKS HHHCCCCCHHHHCHH | 37.14 | 29136822 | |
| 421 | Phosphorylation | PPTFQQQSKSHQKSQ CCCHHHHCHHHHHHH | 31.61 | 29136822 | |
| 422 | Ubiquitination | PTFQQQSKSHQKSQV CCHHHHCHHHHHHHC | 47.85 | 17644757 | |
| 427 | Phosphorylation | QSKSHQKSQVDHETA HCHHHHHHHCCHHHH | 28.94 | 23749301 | |
| 433 | Phosphorylation | KSQVDHETAKQHARR HHHCCHHHHHHHHHH | 35.42 | 23749301 | |
| 435 | Acetylation | QVDHETAKQHARRMA HCCHHHHHHHHHHHH | 50.46 | 25381059 | |
| 435 | Ubiquitination | QVDHETAKQHARRMA HCCHHHHHHHHHHHH | 50.46 | 23749301 | |
| 443 | Phosphorylation | QHARRMASAITQQRT HHHHHHHHHHHHHCC | 15.74 | 23749301 | |
| 454 | Phosphorylation | QQRTYHQSPFMDQYK HHCCCCCCCCHHHHC | 13.54 | 23749301 | |
| 460 | Phosphorylation | QSPFMDQYKEEDSTV CCCCHHHHCCCCCCE | 18.99 | 23749301 | |
| 461 | Ubiquitination | SPFMDQYKEEDSTVS CCCHHHHCCCCCCEE | 49.33 | 22106047 | |
| 472 | Phosphorylation | STVSILPTSLPQIHR CCEEECCCCCHHHHH | 39.18 | 21440633 | |
| 487 | Phosphorylation | ANMLAQGSPAASKIS HHHHHCCCCCHHHCC | 10.17 | 22369663 | |
| 491 | Phosphorylation | AQGSPAASKISPLVT HCCCCCHHHCCCCCC | 32.40 | 22369663 | |
| 492 | Ubiquitination | QGSPAASKISPLVTK CCCCCHHHCCCCCCC | 42.34 | 23749301 | |
| 494 | Phosphorylation | SPAASKISPLVTKKS CCCHHHCCCCCCCCC | 18.87 | 29734811 | |
| 499 | Ubiquitination | KISPLVTKKSKTRWH HCCCCCCCCCCCCEE | 47.79 | 17644757 | |
| 500 | Ubiquitination | ISPLVTKKSKTRWHF CCCCCCCCCCCCEEC | 48.06 | 17644757 | |
| 513 | Phosphorylation | HFGIRSRSYPLDVMG ECCCCCCCCCCCHHH | 32.14 | 27017623 | |
| 514 | Phosphorylation | FGIRSRSYPLDVMGE CCCCCCCCCCCHHHH | 13.50 | 27017623 | |
| 527 | Ubiquitination | GEIYIALKNLGAEWA HHHHHHHHHCCCCCC | 40.90 | 17644757 | |
| 535 | Ubiquitination | NLGAEWAKPSEEDLW HCCCCCCCCCHHHCE | 50.58 | 17644757 | |
| 537 | Phosphorylation | GAEWAKPSEEDLWTI CCCCCCCCHHHCEEE | 53.57 | 23749301 | |
| 545 | Ubiquitination | EEDLWTIKLRWKYDI HHHCEEEEEEEEEEC | 25.32 | 17644757 | |
| 549 | Sumoylation | WTIKLRWKYDIGNKT EEEEEEEEEECCCCC | 26.98 | 24108357 | |
| 561 | Ubiquitination | NKTNTNEKIPDLMKM CCCCCCCCCCHHHHH | 62.70 | 23749301 | |
| 630 | Phosphorylation | IMELAVNSQSN---- HHHHHHHHCCC---- | 28.52 | 23749301 | |
| 632 | Phosphorylation | ELAVNSQSN------ HHHHHHCCC------ | 44.31 | 2557546 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 210 | T | Phosphorylation | Kinase | SNF1 | P06782 | GPS |
| 210 | T | Phosphorylation | Kinase | CCDPK | - | PhosphoELM |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNF1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203; THR-210; SER-211;SER-214; SER-401; SER-411; SER-413; THR-416 AND SER-487, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, AND MASSSPECTROMETRY. | |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, AND MASSSPECTROMETRY. | |
| "Yeast Pak1 kinase associates with and activates Snf1."; Nath N., McCartney R.R., Schmidt M.C.; Mol. Cell. Biol. 23:3909-3917(2003). Cited for: PHOSPHORYLATION AT THR-210, AND INTERACTION WITH SAK1. | |
| "Mammalian AMP-activated protein kinase shares structural andfunctional homology with the catalytic domain of yeast Snf1 proteinkinase."; Mitchelhill K.I., Stapleton D., Gao G., House C., Michell B.,Katsis F., Witters L.A., Kemp B.E.; J. Biol. Chem. 269:2361-2364(1994). Cited for: PROTEIN SEQUENCE OF 274-284; 528-539 AND 622-630, AND PHOSPHORYLATIONAT THR-210. | |
