GPT2_YEAST - dbPTM
GPT2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPT2_YEAST
UniProt AC P36148
Protein Name Glycerol-3-phosphate O-acyltransferase 2
Gene Name GPT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 743
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase..
Protein Sequence MSAPAADHNAAKPIPHVPQASRRYKNSYNGFVYNIHTWLYDVSVFLFNILFTIFFREIKVRGAYNVPEVGVPTILVCAPHANQFIDPALVMSQTRLLKTSAGKSRSRMPCFVTAESSFKKRFISFFGHAMGGIPVPRIQDNLKPVDENLEIYAPDLKNHPEIIKGRSKNPQTTPVNFTKRFSAKSLLGLPDYLSNAQIKEIPDDETIILSSPFRTSKSKVVELLTNGTNFKYAEKIDNTETFQSVFDHLHTKGCVGIFPEGGSHDRPSLLPIKAGVAIMALGAVAADPTMKVAVVPCGLHYFHRNKFRSRAVLEYGEPIVVDGKYGEMYKDSPRETVSKLLKKITNSLFSVTENAPDYDTLMVIQAARRLYQPVKVRLPLPAIVEINRRLLFGYSKFKDDPRIIHLKKLVYDYNRKLDSVGLKDHQVMQLKTTKLEALRCFVTLIVRLIKFSVFAILSLPGSILFTPIFIICRVYSEKKAKEGLKKSLVKIKGTDLLATWKLIVALILAPILYVTYSILLIILARKQHYCRIWVPSNNAFIQFVYFYALLVFTTYSSLKTGEIGVDLFKSLRPLFVSIVYPGKKIEEIQTTRKNLSLELTAVCNDLGPLVFPDYDKLATEIFSKRDGYDVSSDAESSISRMSVQSRSRSSSIHSIGSLASNALSRVNSRGSLTDIPIFSDAKQGQWKSEGETSEDEDEFDEKNPAIVQTARSSDLNKENSRNTNISSKIASLVRQKREHEKKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAPAADHN
------CCCCCCCCC		42.8524961812
12AcetylationAADHNAAKPIPHVPQ
CCCCCCCCCCCCCCH		40.8625381059
113PhosphorylationSRMPCFVTAESSFKK
CCCCEEEEECHHHHH		12.4019779198
143AcetylationPRIQDNLKPVDENLE
CCCCCCCCCCCCCCE		49.6124489116
211PhosphorylationDETIILSSPFRTSKS
CCCEEECCCCCCCCH		25.3128889911
225PhosphorylationSKVVELLTNGTNFKY
HHHHHHHHCCCCCEE		44.2028889911
231AcetylationLTNGTNFKYAEKIDN
HHCCCCCEEEEECCC		45.6924489116
596PhosphorylationQTTRKNLSLELTAVC
HHCCCCCCHHHHHHC		29.2319779198
600PhosphorylationKNLSLELTAVCNDLG
CCCCHHHHHHCCCCC		13.9919779198
614PhosphorylationGPLVFPDYDKLATEI
CCCCCCCHHHHHHHH		18.4019779198
628PhosphorylationIFSKRDGYDVSSDAE
HHHCCCCCCCCCCCC		19.9122369663
631PhosphorylationKRDGYDVSSDAESSI
CCCCCCCCCCCCHHH		21.4322369663
632PhosphorylationRDGYDVSSDAESSIS
CCCCCCCCCCCHHHH		40.4622369663
636PhosphorylationDVSSDAESSISRMSV
CCCCCCCHHHHHHCH		34.3922369663
637PhosphorylationVSSDAESSISRMSVQ
CCCCCCHHHHHHCHH		18.9822369663
639PhosphorylationSDAESSISRMSVQSR
CCCCHHHHHHCHHCC		24.7122369663
647PhosphorylationRMSVQSRSRSSSIHS
HHCHHCCCCCCCCHH		41.5819795423
649PhosphorylationSVQSRSRSSSIHSIG
CHHCCCCCCCCHHHH		29.6822369663
650PhosphorylationVQSRSRSSSIHSIGS
HHCCCCCCCCHHHHH		32.0022369663
651PhosphorylationQSRSRSSSIHSIGSL
HCCCCCCCCHHHHHH		26.1022369663
654PhosphorylationSRSSSIHSIGSLASN
CCCCCCHHHHHHHHH		27.2922369663
657PhosphorylationSSIHSIGSLASNALS
CCCHHHHHHHHHHHH		21.0622369663
660PhosphorylationHSIGSLASNALSRVN
HHHHHHHHHHHHHCC		28.1222369663
664PhosphorylationSLASNALSRVNSRGS
HHHHHHHHHCCCCCC		31.6022369663
668PhosphorylationNALSRVNSRGSLTDI
HHHHHCCCCCCCCCC		34.8522369663
671PhosphorylationSRVNSRGSLTDIPIF
HHCCCCCCCCCCCCC		27.3022369663
673PhosphorylationVNSRGSLTDIPIFSD
CCCCCCCCCCCCCCC		33.3122369663
679PhosphorylationLTDIPIFSDAKQGQW
CCCCCCCCCCCCCCC		37.0622890988
688PhosphorylationAKQGQWKSEGETSED
CCCCCCCCCCCCCCC		48.1222369663
692PhosphorylationQWKSEGETSEDEDEF
CCCCCCCCCCCHHHC		48.5522369663
693PhosphorylationWKSEGETSEDEDEFD
CCCCCCCCCCHHHCH		38.4522369663
728AcetylationRNTNISSKIASLVRQ
CCCCHHHHHHHHHHH		35.1924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPT2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
664SPhosphorylation

19779198
668SPhosphorylation

17330950
671SPhosphorylation

17330950
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPT2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPT1_YEASTSCT1genetic
16269340
CAB5_YEASTCAB5genetic
16269340
COPD_YEASTRET2genetic
16269340
ERFB_YEASTERF2genetic
16269340
HMDH1_YEASTHMG1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
BFR1_YEASTBFR1genetic
16269340
ALG5_YEASTALG5physical
18467557
DEP1_YEASTDEP1genetic
20093466
YAJ9_YEASTYAR029Wgenetic
20093466
GPT1_YEASTSCT1genetic
20093466
ECM33_YEASTECM33genetic
20093466
IST2_YEASTIST2genetic
20093466
STE50_YEASTSTE50genetic
20093466
RV161_YEASTRVS161genetic
20093466
THRC_YEASTTHR4genetic
20093466
SLX5_YEASTSLX5genetic
20093466
RV167_YEASTRVS167genetic
20093466
SNX41_YEASTSNX41genetic
20093466
RPOM_YEASTRPO41genetic
20093466
WWM1_YEASTWWM1genetic
20093466
BLM10_YEASTBLM10genetic
20093466
RTG2_YEASTRTG2genetic
20093466
RTF1_YEASTRTF1genetic
20093466
PALF_YEASTRIM8genetic
20093466
CGR1_YEASTCGR1genetic
20093466
MSB2_YEASTMSB2genetic
20093466
LRP1_YEASTLRP1genetic
20093466
ESL1_YEASTESL1genetic
20093466
APQ12_YEASTAPQ12genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
YJ09_YEASTYJR039Wgenetic
20093466
AIM25_YEASTAIM25genetic
20093466
MDM35_YEASTMDM35genetic
20093466
UBI4P_YEASTUBI4genetic
20093466
ROM2_YEASTROM2genetic
20093466
ELO3_YEASTELO3genetic
20093466
SUB1_YEASTSUB1genetic
20093466
LSM7_YEASTLSM7genetic
20093466
YNK8_YEASTYNL108Cgenetic
20093466
RS7B_YEASTRPS7Bgenetic
20093466
YPT53_YEASTYPT53genetic
20093466
MSG5_YEASTMSG5genetic
20093466
SLM2_YEASTSLM2genetic
20093466
ADH1_YEASTADH1genetic
20093466
IRA2_YEASTIRA2genetic
20093466
NOP12_YEASTNOP12genetic
20093466
PHO80_YEASTPHO80genetic
20093466
SGT2_YEASTSGT2genetic
20093466
VAM3_YEASTVAM3genetic
20093466
GDS1_YEASTGDS1genetic
20093466
PDE2_YEASTPDE2genetic
20093466
KEL3_YEASTKEL3genetic
20093466
SUR1_YEASTSUR1genetic
20093466
REC8_YEASTREC8genetic
20093466
NAA30_YEASTMAK3genetic
20093466
NHP6A_YEASTNHP6Agenetic
20093466
BRR1_YEASTBRR1genetic
20093466
UBA3_YEASTUBA3genetic
20093466
YLH47_YEASTYLH47genetic
20093466
ASNS1_YEASTASN1genetic
20093466
MLC2_YEASTMLC2genetic
20093466
GPT1_YEASTSCT1genetic
11544256
GPT1_YEASTSCT1genetic
12167660
SPO14_YEASTSPO14genetic
12167660
GPT1_YEASTSCT1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
ATF1_YEASTATF1genetic
21623372
GPD1_YEASTGPD1genetic
21623372
MAL33_YEASTMAL33genetic
21127252
RAD51_YEASTRAD51genetic
21127252
AAKG_YEASTSNF4genetic
23891562
MSH4_YEASTMSH4genetic
27708008
WWM1_YEASTWWM1genetic
27708008
IES1_YEASTIES1genetic
27708008
SYH1_YEASTSYH1genetic
27708008
SGE1_YEASTSGE1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
GPT1_YEASTSCT1genetic
27708008
NU170_YEASTNUP170genetic
27708008
CSG2_YEASTCSG2genetic
27708008
ECM33_YEASTECM33genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
RV161_YEASTRVS161genetic
27708008
MTU1_YEASTSLM3genetic
27708008
YD183_YEASTYDL183Cgenetic
27708008
AAD4_YEASTAAD4genetic
27708008
UBC13_YEASTUBC13genetic
27708008
SWF1_YEASTSWF1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
TFS2_YEASTDST1genetic
27708008
AAKG_YEASTSNF4genetic
27708008
CWC26_YEASTBUD13genetic
27708008
RTG2_YEASTRTG2genetic
27708008
ACBP_YEASTACB1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
LRP1_YEASTLRP1genetic
27708008
SOL3_YEASTSOL3genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ESL1_YEASTESL1genetic
27708008
MPH1_YEASTMPH1genetic
27708008
SET2_YEASTSET2genetic
27708008
PHO90_YEASTPHO90genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
MDM35_YEASTMDM35genetic
27708008
CTK1_YEASTCTK1genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
UPS1_YEASTUPS1genetic
27708008
FAR10_YEASTFAR10genetic
27708008
CSC1_YEASTCSC1genetic
27708008
ARV1_YEASTARV1genetic
27708008
SPH1_YEASTSPH1genetic
27708008
NKP2_YEASTNKP2genetic
27708008
ARPC3_YEASTARC18genetic
27708008
ELO3_YEASTELO3genetic
27708008
YL413_YEASTINA1genetic
27708008
SCJ1_YEASTSCJ1genetic
27708008
YPT53_YEASTYPT53genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
YNO3_YEASTYNL143Cgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
PFD4_YEASTGIM3genetic
27708008
PHO80_YEASTPHO80genetic
27708008
RTG1_YEASTRTG1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
SGT2_YEASTSGT2genetic
27708008
FYV12_YEASTFYV12genetic
27708008
PDE2_YEASTPDE2genetic
27708008
CHL1_YEASTCHL1genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HUT1_YEASTHUT1genetic
27708008
EAF3_YEASTEAF3genetic
27708008
THP3_YEASTTHP3genetic
27708008
BRR1_YEASTBRR1genetic
27708008
MMS1_YEASTMMS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPT2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-631; SER-632;SER-668; SER-671; THR-673; SER-688; THR-692 AND SER-693, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-637; SER-688AND SER-693, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-654; SER-668 ANDSER-671, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND SER-671, ANDMASS SPECTROMETRY.

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