| UniProt ID | MLC2_YEAST | |
|---|---|---|
| UniProt AC | Q06580 | |
| Protein Name | Myosin light chain 2 | |
| Gene Name | MLC2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 163 | |
| Subcellular Localization | Bud neck . Forms a ring at the bud neck in a MYO1-dependent manner. | |
| Protein Description | Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis.. | |
| Protein Sequence | MDHSESLTFNQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTSTAEVGEEGVSFPIFLSIMGKNLSQFPEREELEESLKAIGRGHDLNVPLNEVIDSLKEAGFENPEEEFAKLFKLFTTNQQATEERTFRGKLFLDSITD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MDHSESLTFNQ ----CCHHHCCCHHH | 25.31 | 22369663 | |
| 6 | Phosphorylation | --MDHSESLTFNQLT --CCHHHCCCHHHHH | 35.41 | 22369663 | |
| 8 | Phosphorylation | MDHSESLTFNQLTQD CCHHHCCCHHHHHHH | 29.80 | 24909858 | |
| 36 | Phosphorylation | EDEDGLISRGDLTKI CCCCCCCCHHHHHHH | 34.94 | 21440633 | |
| 42 | Acetylation | ISRGDLTKIYATLGK CCHHHHHHHHHHCCC | 40.80 | 24489116 | |
| 52 | Phosphorylation | ATLGKTLTDEEWSKM HHCCCCCCHHHHHHC | 46.74 | 30377154 | |
| 66 | Phosphorylation | MVPDNDTSTAEVGEE CCCCCCCCCHHCCCC | 28.60 | 27017623 | |
| 76 | Phosphorylation | EVGEEGVSFPIFLSI HCCCCCCCHHHHHHH | 35.84 | 27017623 | |
| 89 | Phosphorylation | SIMGKNLSQFPEREE HHHCCCHHHCCCHHH | 38.89 | 27017623 | |
| 100 | Phosphorylation | EREELEESLKAIGRG CHHHHHHHHHHHHCC | 26.29 | 30377154 | |
| 102 | Acetylation | EELEESLKAIGRGHD HHHHHHHHHHHCCCC | 47.43 | 24489116 | |
| 135 | Acetylation | NPEEEFAKLFKLFTT CHHHHHHHHHHHHHC | 60.83 | 24489116 | |
| 155 | Ubiquitination | EERTFRGKLFLDSIT CCCCCCCEEHHHCCC | 31.63 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MLC2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MLC2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MLC2_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MYO1_YEAST | MYO1 | physical | 15210731 | |
| SLF1_YEAST | SLF1 | physical | 16554755 | |
| MLC1_YEAST | MLC1 | physical | 16554755 | |
| MYO1_YEAST | MYO1 | physical | 16554755 | |
| IQG1_YEAST | IQG1 | genetic | 19109423 | |
| MYO1_YEAST | MYO1 | physical | 21757693 | |
| UAP1_YEAST | QRI1 | genetic | 27708008 | |
| MAK21_YEAST | MAK21 | genetic | 27708008 | |
| ACT_YEAST | ACT1 | genetic | 27708008 | |
| CBF3B_YEAST | CEP3 | genetic | 27708008 | |
| CAP_YEAST | SRV2 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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