| UniProt ID | MAK21_YEAST | |
|---|---|---|
| UniProt AC | Q12176 | |
| Protein Name | Ribosome biogenesis protein MAK21 | |
| Gene Name | MAK21 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1025 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for 60S ribosomal subunit synthesis.. | |
| Protein Sequence | MSENNGNPLDLSSLRNKISSKLRDNNSKKAKKTHKGKDVKASSNSKKVNEDIRREALALGASEEDLKLIQGLSDDDDAKSEQEFDAVADEDADDKGFKNDLQNFMKNVGFDQHKLEDVDDDDIEEESTSSKESKIPAQEKEHAQSNIASSTIEKTSQESIDNGSEQEENTVEEANLSSDQEPESESAEKEKKEEKDGGLITQTTIISSDKLIIPYDKPWYEIPLDPQVGQNDDVEELSKEQIEKLFERGKQTLEADNQTYYEEFTKDSSQAKFMSQILSDGTLNDKISAVTLLIQDSPLHNTKSLETLVSYCGKKSRNSALQSLNALKDLFLNGLLPNRKLRYFKNQPGLSMMLNKKTLAIFYFEDYLKKLFFRVLEVLEVLSHDPIIHVRLQILNHVFDLLTNQPEQEFNLLRLGVNKIGDIDSKVSSKASYLLLKLEQAHPNMKSIVIDAIVDIALRPNADYHTTYYSVITLNQTILKRSEDSVANKLVKTYFTLFEKFLINTDKDNTNGVVKSNSKSYEEKRKKNFKKGKHGGKSVKIEKTENEVLDEKNSKLFSALLTGINRAFPFAQIPASVYEVHMETLFKITHSSNFNTSIQALVLINQVTVKAKLNSDRYYRTLYESLFDPRLVNSSKQGIYLNLLYKSLKQDALNVERVEAFVKRILQVCSHWLNVGTITGFFFLLIQLAKTVPQIKNLLTNTPVDYEYESDAEEEQGDKDIKRKEYDGRKRDPKFANAEKSSLWEINNFINHFHPTVKTYANAYVTGETEQIAKPDLGLFTLSHFLDRFVYRSAKQTNTARGTSIMQPLFSGSRVNDSVLVKASDIMHDQGPVNTEDWLTKKVEDIKPEDKFFYQYFTTKKTADGKGKKSNKASNFDSDDEMDENEIWSALVKSRPDVEDDSDDSELDFAEDDFSDSTSDDEPKLDAIDDEDAKSEGSQESDQEEGLDEDIFYSFDGEQDNSDKKRSFAESSEEDESSEEEKEEEENKEVSAKRAKKKQRKNMLKSLPVFASADDYAQYLDQDSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSENNGNPL ------CCCCCCCCC | 61.41 | 28152593 | |
| 2 | Acetylation | ------MSENNGNPL ------CCCCCCCCC | 61.41 | 22814378 | |
| 12 | Phosphorylation | NGNPLDLSSLRNKIS CCCCCCHHHHHHHHH | 27.30 | 19823750 | |
| 13 | Phosphorylation | GNPLDLSSLRNKISS CCCCCHHHHHHHHHH | 38.35 | 19823750 | |
| 19 | Phosphorylation | SSLRNKISSKLRDNN HHHHHHHHHHHHCCC | 24.03 | 19823750 | |
| 20 | Phosphorylation | SLRNKISSKLRDNNS HHHHHHHHHHHCCCC | 38.90 | 19823750 | |
| 27 | Phosphorylation | SKLRDNNSKKAKKTH HHHHCCCCHHHCHHH | 41.61 | 19823750 | |
| 62 | Phosphorylation | EALALGASEEDLKLI HHHHCCCCHHHHHHH | 39.46 | 22369663 | |
| 73 | Phosphorylation | LKLIQGLSDDDDAKS HHHHHCCCCCCCHHC | 45.90 | 22369663 | |
| 80 | Phosphorylation | SDDDDAKSEQEFDAV CCCCCHHCHHHHHHH | 46.35 | 22369663 | |
| 106 | Acetylation | NDLQNFMKNVGFDQH HHHHHHHHHCCCCHH | 44.32 | 22865919 | |
| 127 | Phosphorylation | DDDIEEESTSSKESK CCCCCCCCCCCCCCC | 36.55 | 17330950 | |
| 128 | Phosphorylation | DDIEEESTSSKESKI CCCCCCCCCCCCCCC | 40.06 | 25521595 | |
| 129 | Phosphorylation | DIEEESTSSKESKIP CCCCCCCCCCCCCCC | 49.01 | 25521595 | |
| 130 | Phosphorylation | IEEESTSSKESKIPA CCCCCCCCCCCCCCH | 40.30 | 21440633 | |
| 133 | Phosphorylation | ESTSSKESKIPAQEK CCCCCCCCCCCHHHH | 39.35 | 19795423 | |
| 140 | Acetylation | SKIPAQEKEHAQSNI CCCCHHHHHHHHHHH | 42.60 | 24489116 | |
| 149 | Phosphorylation | HAQSNIASSTIEKTS HHHHHHCCHHHHHHC | 24.98 | 21551504 | |
| 150 | Phosphorylation | AQSNIASSTIEKTSQ HHHHHCCHHHHHHCH | 25.12 | 30377154 | |
| 155 | Phosphorylation | ASSTIEKTSQESIDN CCHHHHHHCHHHCCC | 23.89 | 19795423 | |
| 156 | Phosphorylation | SSTIEKTSQESIDNG CHHHHHHCHHHCCCC | 42.91 | 19795423 | |
| 159 | Phosphorylation | IEKTSQESIDNGSEQ HHHHCHHHCCCCCHH | 27.83 | 20377248 | |
| 164 | Phosphorylation | QESIDNGSEQEENTV HHHCCCCCHHHCHHH | 42.22 | 20377248 | |
| 170 | Phosphorylation | GSEQEENTVEEANLS CCHHHCHHHHHHCCC | 32.35 | 19795423 | |
| 177 | Phosphorylation | TVEEANLSSDQEPES HHHHHCCCCCCCCCC | 31.51 | 20377248 | |
| 178 | Phosphorylation | VEEANLSSDQEPESE HHHHCCCCCCCCCCH | 46.62 | 20377248 | |
| 184 | Phosphorylation | SSDQEPESESAEKEK CCCCCCCCHHHHHHH | 47.79 | 21551504 | |
| 186 | Phosphorylation | DQEPESESAEKEKKE CCCCCCHHHHHHHHH | 51.51 | 21551504 | |
| 204 | Phosphorylation | GGLITQTTIISSDKL CCCCCCEEEEECCCE | 13.39 | 28889911 | |
| 244 | Acetylation | LSKEQIEKLFERGKQ HHHHHHHHHHHHHHH | 61.17 | 24489116 | |
| 275 | Phosphorylation | SSQAKFMSQILSDGT HHHHHHHHHHHCCCC | 19.73 | 28889911 | |
| 279 | Phosphorylation | KFMSQILSDGTLNDK HHHHHHHCCCCCCCC | 35.31 | 30377154 | |
| 419 | Ubiquitination | LLRLGVNKIGDIDSK HHHCCCCCCCCCCHH | 45.73 | 23749301 | |
| 437 | Acetylation | KASYLLLKLEQAHPN HHHHHHHHHHHHCCC | 50.36 | 24489116 | |
| 492 | Acetylation | SVANKLVKTYFTLFE HHHHHHHHHHHHHHH | 48.20 | 24489116 | |
| 507 | Acetylation | KFLINTDKDNTNGVV HHHCCCCCCCCCCCC | 51.33 | 24489116 | |
| 533 | Acetylation | KKNFKKGKHGGKSVK HHHCCCCCCCCEECE | 48.21 | 25381059 | |
| 537 | Acetylation | KKGKHGGKSVKIEKT CCCCCCCEECEEEEC | 57.58 | 25381059 | |
| 700 | Phosphorylation | PQIKNLLTNTPVDYE HHHHHHHHCCCCCCC | 39.97 | 22890988 | |
| 702 | Phosphorylation | IKNLLTNTPVDYEYE HHHHHHCCCCCCCCC | 21.32 | 22890988 | |
| 706 | Phosphorylation | LTNTPVDYEYESDAE HHCCCCCCCCCCHHH | 22.20 | 22890988 | |
| 708 | Phosphorylation | NTPVDYEYESDAEEE CCCCCCCCCCHHHHH | 17.95 | 25521595 | |
| 710 | Phosphorylation | PVDYEYESDAEEEQG CCCCCCCCHHHHHCC | 41.02 | 22369663 | |
| 740 | Acetylation | PKFANAEKSSLWEIN HHHCCCHHHHHHHHH | 42.82 | 24489116 | |
| 803 | Phosphorylation | QTNTARGTSIMQPLF CCCCCCCCCCCCCCC | 14.99 | 30377154 | |
| 818 | Phosphorylation | SGSRVNDSVLVKASD CCCCCCCEEEEEHHH | 16.49 | 27214570 | |
| 854 | Phosphorylation | KPEDKFFYQYFTTKK CCCCCCHHHHHCCCC | 12.87 | 21551504 | |
| 856 | Phosphorylation | EDKFFYQYFTTKKTA CCCCHHHHHCCCCCC | 7.48 | 21551504 | |
| 858 | Phosphorylation | KFFYQYFTTKKTADG CCHHHHHCCCCCCCC | 32.54 | 21551504 | |
| 859 | Phosphorylation | FFYQYFTTKKTADGK CHHHHHCCCCCCCCC | 22.20 | 21551504 | |
| 874 | Phosphorylation | GKKSNKASNFDSDDE CCCCCCCCCCCCCCC | 39.37 | 22369663 | |
| 878 | Phosphorylation | NKASNFDSDDEMDEN CCCCCCCCCCCCCHH | 42.71 | 22369663 | |
| 889 | Phosphorylation | MDENEIWSALVKSRP CCHHHHHHHHHHCCC | 19.86 | 26447709 | |
| 967 | Phosphorylation | DNSDKKRSFAESSEE CCCHHHHCHHHCCCC | 37.37 | 22890988 | |
| 971 | Phosphorylation | KKRSFAESSEEDESS HHHCHHHCCCCCCCC | 39.35 | 22890988 | |
| 972 | Phosphorylation | KRSFAESSEEDESSE HHCHHHCCCCCCCCH | 36.19 | 22890988 | |
| 977 | Phosphorylation | ESSEEDESSEEEKEE HCCCCCCCCHHHHHH | 56.20 | 22890988 | |
| 978 | Phosphorylation | SSEEDESSEEEKEEE CCCCCCCCHHHHHHH | 47.16 | 22890988 | |
| 1006 | Phosphorylation | QRKNMLKSLPVFASA HHHHHHHHCCCCCCH | 33.66 | 22890988 | |
| 1012 | Phosphorylation | KSLPVFASADDYAQY HHCCCCCCHHHHHHH | 22.29 | 22890988 | |
| 1016 | Phosphorylation | VFASADDYAQYLDQD CCCCHHHHHHHHHCC | 8.99 | 22890988 | |
| 1019 | Phosphorylation | SADDYAQYLDQDSD- CHHHHHHHHHCCCC- | 12.22 | 22890988 | |
| 1024 | Phosphorylation | AQYLDQDSD------ HHHHHCCCC------ | 39.32 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAK21_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAK21_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAK21_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-73; SER-80;TYR-708; SER-710 AND SER-878, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-80 AND SER-710,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-73; SER-80;SER-977 AND SER-978, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710, AND MASSSPECTROMETRY. | |
