| UniProt ID | NOP3_YEAST | |
|---|---|---|
| UniProt AC | Q01560 | |
| Protein Name | Nucleolar protein 3 | |
| Gene Name | NPL3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 414 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for pre-rRNA processing and nuclear import as well as mitochondrial protein targeting. Binds to poly(A).. | |
| Protein Sequence | MSEAQETHVEQLPESVVDAPVEEQHQEPPQAPDAPQEPQVPQESAPQESAPQEPPAPQEQNDVPPPSNAPIYEGEESHSVQDYQEAHQHHQPPEPQPYYPPPPPGEHMHGRPPMHHRQEGELSNTRLFVRPFPLDVQESELNEIFGPFGPMKEVKILNGFAFVEFEEAESAAKAIEEVHGKSFANQPLEVVYSKLPAKRYRITMKNLPEGCSWQDLKDLARENSLETTFSSVNTRDFDGTGALEFPSEEILVEALERLNNIEFRGSVITVERDDNPPPIRRSNRGGFRGRGGFRGGFRGGFRGGFSRGGFGGPRGGFGGPRGGYGGYSRGGYGGYSRGGYGGSRGGYDSPRGGYDSPRGGYSRGGYGGPRNDYGPPRGSYGGSRGGYDGPRGDYGPPRDAYRTRDAPRERSPTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 123 | Phosphorylation | HRQEGELSNTRLFVR CCCCCCCCCEEEEEE | 31.67 | 28889911 | |
| 181 | Acetylation | AIEEVHGKSFANQPL HHHHHHCCHHCCCCC | 27.76 | 24489116 | |
| 182 | Phosphorylation | IEEVHGKSFANQPLE HHHHHCCHHCCCCCC | 33.90 | 25752575 | |
| 194 | Succinylation | PLEVVYSKLPAKRYR CCCHHHCCCCCCCEE | 40.58 | 23954790 | |
| 194 | Acetylation | PLEVVYSKLPAKRYR CCCHHHCCCCCCCEE | 40.58 | 24489116 | |
| 194 | Ubiquitination | PLEVVYSKLPAKRYR CCCHHHCCCCCCCEE | 40.58 | 24961812 | |
| 212 | Phosphorylation | KNLPEGCSWQDLKDL CCCCCCCCHHHHHHH | 38.33 | 21440633 | |
| 217 | Acetylation | GCSWQDLKDLARENS CCCHHHHHHHHHHCC | 60.01 | 24489116 | |
| 224 | Phosphorylation | KDLARENSLETTFSS HHHHHHCCCEEECCC | 23.88 | 22369663 | |
| 227 | Phosphorylation | ARENSLETTFSSVNT HHHCCCEEECCCCCC | 38.13 | 22890988 | |
| 228 | Phosphorylation | RENSLETTFSSVNTR HHCCCEEECCCCCCC | 16.49 | 22890988 | |
| 230 | Phosphorylation | NSLETTFSSVNTRDF CCCEEECCCCCCCCC | 31.14 | 22369663 | |
| 231 | Phosphorylation | SLETTFSSVNTRDFD CCEEECCCCCCCCCC | 18.39 | 22369663 | |
| 234 | Phosphorylation | TTFSSVNTRDFDGTG EECCCCCCCCCCCCC | 29.47 | 22369663 | |
| 343 | Phosphorylation | SRGGYGGSRGGYDSP CCCCCCCCCCCCCCC | 24.32 | 27017623 | |
| 347 | Phosphorylation | YGGSRGGYDSPRGGY CCCCCCCCCCCCCCC | 18.97 | 28889911 | |
| 349 | Phosphorylation | GSRGGYDSPRGGYDS CCCCCCCCCCCCCCC | 14.17 | 11875433 | |
| 354 | Phosphorylation | YDSPRGGYDSPRGGY CCCCCCCCCCCCCCC | 18.97 | 27017623 | |
| 356 | Phosphorylation | SPRGGYDSPRGGYSR CCCCCCCCCCCCCCC | 14.17 | 23749301 | |
| 380 | Phosphorylation | YGPPRGSYGGSRGGY CCCCCCCCCCCCCCC | 28.47 | 19779198 | |
| 411 | Phosphorylation | RDAPRERSPTR---- CCCCCCCCCCC---- | 26.35 | 24909858 | |
| 413 | Phosphorylation | APRERSPTR------ CCCCCCCCC------ | 50.70 | 24909858 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOP3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOP3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; SER-224 ANDTHR-228, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND THR-227, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND MASSSPECTROMETRY. | |
