FRE7_YEAST - dbPTM
FRE7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRE7_YEAST
UniProt AC Q12333
Protein Name Ferric/cupric reductase transmembrane component 7
Gene Name FRE7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 620
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Cell surface metalloreductase. May be involved in copper homeostasis..
Protein Sequence MIEERDLVLSNGIHCIADIHSELYARLKKESQAATPWVYQKQYGKFVTYFVAVIIFLSLIKKLAFMYYDSSEEFLPEKKNSPTTPSVFLARIMTKLVAFNRYICYRKFPTLIFSYLGIPTSVGTFLVVMATTLYTLLYCFVPHPFYRPCAGFGSPPLSVRAGIMAISLVPFVFSLSGKINVIGWLVGLSYEKINIYHQWASILCLFFSWVHVIPFLRQARHEGGYERMHQRWKASDMWRSGVPPILFLNLLWLSSLPIARRHFYEIFLQLHWILAVGFYISLFYHVYPELNSHMYLVATIVVWFAQLFYRLAVKGYLRPGRSFMASTIANVSIVGEGCVELIVKDVEMAYSPGQHIFVRTIDKGIISNHPFSIFPSAKYPGGIKMLIRAQKGFSKRLYESNDDMKKILIDGPYGGIERDIRSFTNVYLICSGSGISTCLPFLQKYGPILHKTNLEVITLDWVVRHREDISWIRDEMCTLSNNLRQLFLDGKIVVRIYVCSDSTVPGIIKTFPQTIDTASDQSDLAKREKDTEFGQDDTESNSTFDKSNNEYKGLITIIPSKPDLNQVINDYQIGFRNCFICSGSDSLRYTVGNSVAGLQAKVFSNKNVEECYLHSESFGY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
367PhosphorylationTIDKGIISNHPFSIF
EECCCHHCCCCCEEC		27.4528889911
517PhosphorylationTFPQTIDTASDQSDL
HCCHHHCCCCCHHHH		24.9820377248
519PhosphorylationPQTIDTASDQSDLAK
CHHHCCCCCHHHHHH		37.9720377248
522PhosphorylationIDTASDQSDLAKREK
HCCCCCHHHHHHHHH		39.3120377248
526UbiquitinationSDQSDLAKREKDTEF
CCHHHHHHHHHCCCC		69.2722817900
529UbiquitinationSDLAKREKDTEFGQD
HHHHHHHHCCCCCCC		74.1822817900
540PhosphorylationFGQDDTESNSTFDKS
CCCCCCCCCCCCCCC		37.8728889911
542PhosphorylationQDDTESNSTFDKSNN
CCCCCCCCCCCCCCC		39.4728889911
543PhosphorylationDDTESNSTFDKSNNE
CCCCCCCCCCCCCCE		39.8528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRE7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRE7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRE7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NRG1_YEASTNRG1genetic
20093466
SWF1_YEASTSWF1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
SCS2_YEASTSCS2genetic
20093466
RS26B_YEASTRPS26Bgenetic
20093466
ATC1_YEASTPMR1genetic
20093466
FIS1_YEASTFIS1genetic
20093466
YM49_YEASTYMR187Cgenetic
20093466
MKS1_YEASTMKS1genetic
20093466
SIN3_YEASTSIN3genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
CSG2_YEASTCSG2genetic
27708008
RV161_YEASTRVS161genetic
27708008
BRE1_YEASTBRE1genetic
27708008
MED20_YEASTSRB2genetic
27708008
AIM34_YEASTAIM34genetic
27708008
MKS1_YEASTMKS1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SUR1_YEASTSUR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRE7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367, AND MASSSPECTROMETRY.

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