| UniProt ID | CSG2_YEAST | |
|---|---|---|
| UniProt AC | P35206 | |
| Protein Name | Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2 | |
| Gene Name | CSG2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 410 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis.. | |
| Protein Sequence | MSTTLLWFSSVIGYVIQTKCLSNIQSKKEISVGPNGTIATPETNGDNGNSSSLTFYLTFMYFASWLLLVPASRLWEKMRPMFVSDSDSNRNSQFDNNNSGSVTNEDVDTFSHVLDDPQPRIPAQQQKQKIISVATFKYVAKLTVLALIMIVADLTYNMALSLSPAFDVALMQNTAIFEIVTLLYGVCGISRKNYVFRNFLIMMNAVIGILIISYTKATCDMLAGKLSVNPNTGELSDPFLFDRLKGALICGLGALIMGPFAVLWNRWFCSNISKNENSAVVLVKQSTHMALIGIIGMVILLPFIPKFPSRESVESISLFYNDKSFWFSLLGSIIFGSLPSLISILELNRKAPAEYLTTCNLGAIIFMGLAEWVCEPTQTTIVRWEVIGYIMLTVSLLVLSVTLGEGKYHH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MSTTLLWFSS -----CCCHHHHHHH | 21.84 | 28889911 | |
| 9 | Phosphorylation | STTLLWFSSVIGYVI CCHHHHHHHHHHHHH | 16.47 | 28889911 | |
| 10 | Phosphorylation | TTLLWFSSVIGYVIQ CHHHHHHHHHHHHHH | 14.31 | 28889911 | |
| 14 | Phosphorylation | WFSSVIGYVIQTKCL HHHHHHHHHHHHHHH | 5.35 | 28889911 | |
| 18 | Phosphorylation | VIGYVIQTKCLSNIQ HHHHHHHHHHHHCCC | 16.76 | 28889911 | |
| 35 | N-linked_Glycosylation | KEISVGPNGTIATPE CEEEECCCCCCCCCC | 55.07 | - | |
| 49 | N-linked_Glycosylation | ETNGDNGNSSSLTFY CCCCCCCCCHHHHHH | 45.00 | - | |
| 77 | Ubiquitination | PASRLWEKMRPMFVS HHHHHHHHHHCCCCC | 28.73 | 17644757 | |
| 99 | Phosphorylation | SQFDNNNSGSVTNED CCCCCCCCCCCCHHH | 34.27 | 27017623 | |
| 101 | Phosphorylation | FDNNNSGSVTNEDVD CCCCCCCCCCHHHHH | 26.11 | 23749301 | |
| 127 | Ubiquitination | RIPAQQQKQKIISVA CCCHHHHHHCEEHHH | 49.58 | 23749301 | |
| 312 | Phosphorylation | PKFPSRESVESISLF CCCCCCCCCCEEEEE | 30.03 | 27017623 | |
| 320 | Phosphorylation | VESISLFYNDKSFWF CCEEEEEECCHHHHH | 27.95 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CSG2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSG2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSG2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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