OSH6_YEAST - dbPTM
OSH6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OSH6_YEAST
UniProt AC Q02201
Protein Name Oxysterol-binding protein homolog 6
Gene Name OSH6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 448
Subcellular Localization Endoplasmic reticulum membrane . Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.
Protein Description Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. [PubMed: 23934110]
Protein Sequence MGSKKLTVGSDSHRLSKSSFSSNKSSHSATKDQPIDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQKKMIENEKQNPAKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MGSKKLTVGSDSHR
-CCCCEECCCCCCCC		31.5319823750
10PhosphorylationSKKLTVGSDSHRLSK
CCEECCCCCCCCCCH		31.4429136822
12PhosphorylationKLTVGSDSHRLSKSS
EECCCCCCCCCCHHH		16.5319823750
16PhosphorylationGSDSHRLSKSSFSSN
CCCCCCCCHHHCCCC		30.3719823750
18PhosphorylationDSHRLSKSSFSSNKS
CCCCCCHHHCCCCCC		32.9922369663
19PhosphorylationSHRLSKSSFSSNKSS
CCCCCHHHCCCCCCC		32.6522369663
21PhosphorylationRLSKSSFSSNKSSHS
CCCHHHCCCCCCCCC		34.6422369663
22PhosphorylationLSKSSFSSNKSSHSA
CCHHHCCCCCCCCCC		46.3922369663
28PhosphorylationSSNKSSHSATKDQPI
CCCCCCCCCCCCCCC		39.3130377154
273PhosphorylationIEGTVKDYDGNAYYE
EEEEEECCCCCEEEE		21.7419779198
278PhosphorylationKDYDGNAYYEISGKW
ECCCCCEEEEEEEEE		12.9619779198
279PhosphorylationDYDGNAYYEISGKWN
CCCCCEEEEEEEEEC		12.3619779198
300PhosphorylationDLKQPRSSPKVFLDT
CCCCCCCCCCEEECC		29.9827214570
307PhosphorylationSPKVFLDTHKESPLR
CCCEEECCCCCCCCC		36.6721440633
309AcetylationKVFLDTHKESPLRPK
CEEECCCCCCCCCCC		63.0824489116
321PhosphorylationRPKVRPLSEQGEYES
CCCCCCCHHCCCHHH		30.4721440633
328PhosphorylationSEQGEYESRKLWKKV
HHCCCHHHHHHHHHH		33.5429734811
351UbiquitinationHPVATEEKFQIEDHQ
CCCCCHHHCCCHHHH		36.0223749301
392AcetylationDLDYCIYKNIPVDED
CCCEEEEECCCCCCC		28.6124489116
402AcetylationPVDEDPEKQIRSILQ
CCCCCHHHHHHHHHH		57.3124489116
430AcetylationFFIPAFEKIKSQKKM
CCHHHHHHHHHHHHH		49.3224489116
442UbiquitinationKKMIENEKQNPAKQ-
HHHHHHHCCCCCCC-		67.9423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OSH6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OSH6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OSH6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LYS12_YEASTLYS12physical
16554755
TPO4_YEASTTPO4physical
18467557
PIS_YEASTPIS1physical
18467557
OSH7_YEASTOSH7genetic
11238399
KES1_YEASTKES1genetic
21819498
UBP4_YEASTDOA4genetic
21987634
IPK1_YEASTIPK1genetic
21987634
MDY2_YEASTMDY2genetic
21987634
TOR1_YEASTTOR1genetic
22622083
PP2C1_YEASTPTC1genetic
27708008
RU1A_YEASTMUD1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
UBX3_YEASTUBX3genetic
27708008
PEX5_YEASTPEX5genetic
27708008
PMP3_YEASTPMP3genetic
27708008
RV167_YEASTRVS167genetic
27708008
RTF1_YEASTRTF1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
UBCX_YEASTPEX4genetic
27708008
PHB2_YEASTPHB2genetic
27708008
BGL2_YEASTBGL2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
FMO1_YEASTFMO1genetic
27708008
NVJ1_YEASTNVJ1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
VPS35_YEASTVPS35genetic
27708008
MNN11_YEASTMNN11genetic
27708008
ILM1_YEASTILM1genetic
27708008
ENT3_YEASTENT3genetic
27708008
MNS1_YEASTMNS1genetic
27708008
DAN1_YEASTDAN1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
SIC1_YEASTSIC1genetic
27708008
NAH1_YEASTNHA1genetic
27708008
ATP10_YEASTATP10genetic
27708008
PSP2_YEASTPSP2genetic
27708008
COX7_YEASTCOX7genetic
27708008
LEU1_YEASTLEU4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
PT127_YEASTPET127genetic
27708008
NIP80_YEASTNIP100genetic
27708008
FUMH_YEASTFUM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OSH6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.

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