OSH7_YEAST - dbPTM
OSH7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OSH7_YEAST
UniProt AC P38755
Protein Name Oxysterol-binding protein homolog 7
Gene Name OSH7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 437
Subcellular Localization Endoplasmic reticulum membrane . Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.
Protein Description Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner..
Protein Sequence MALNKLKNIPSLTNSSHSSINGIASNAANSKPSGADTDDIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLPNKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPKYQVDIEFKTKGFISGTYDAIEGTIKDYDGKEYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFPLAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEGTDKHEEQIRSILETAPILPGQTFTEKFSIPAYKKHGIQKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationNKLKNIPSLTNSSHS
HHHCCCCCCCCCCCH		43.9922369663
13PhosphorylationLKNIPSLTNSSHSSI
HCCCCCCCCCCCHHH		37.0722369663
15PhosphorylationNIPSLTNSSHSSING
CCCCCCCCCCHHHHH		24.9622369663
16PhosphorylationIPSLTNSSHSSINGI
CCCCCCCCCHHHHHH		29.4722369663
18PhosphorylationSLTNSSHSSINGIAS
CCCCCCCHHHHHHHH		34.5622369663
19PhosphorylationLTNSSHSSINGIASN
CCCCCCHHHHHHHHC		18.0422369663
25PhosphorylationSSINGIASNAANSKP
HHHHHHHHCHHCCCC		25.6919795423
30PhosphorylationIASNAANSKPSGADT
HHHCHHCCCCCCCCC		41.0119795423
76AcetylationLPTFILEKKSMLERI
CCHHHHCHHHHHHHH		46.8624489116
100AcetylationLLEAHSNKDGLQRFV
HHHHHCCCHHHHHHH		57.0724489116
150PhosphorylationPNKQQAFYIAEQTSH
CCHHHEEEEEECCCC		11.3919823750
155PhosphorylationAFYIAEQTSHHPPES
EEEEEECCCCCCCCC		22.8719823750
156PhosphorylationFYIAEQTSHHPPESA
EEEEECCCCCCCCCC		21.3519823750
162PhosphorylationTSHHPPESAYFYMIP
CCCCCCCCCEEEECC		33.7619823750
164PhosphorylationHHPPESAYFYMIPES
CCCCCCCEEEECCCC		12.4319823750
166PhosphorylationPPESAYFYMIPESNI
CCCCCEEEECCCCCE		4.9719823750
171PhosphorylationYFYMIPESNIRVDGV
EEEECCCCCEEECEE		32.0019823750
183PhosphorylationDGVVVPKSKFLGNSS
CEEEEECHHHCCCCH		23.6719823750
271UbiquitinationDAIEGTIKDYDGKEY
EEEEEEEECCCCCEE		50.5022817900
276AcetylationTIKDYDGKEYYQISG
EEECCCCCEEEEEEE		39.3824489116
276UbiquitinationTIKDYDGKEYYQISG
EEECCCCCEEEEEEE		39.3823749301
292AcetylationWNDIMYIKDLREKSS
CCCEEEEHHHHHHHC		32.9724489116
375AcetylationDGVEFHSKLFRRAEP
HHHHHHHHHHHCCCC		42.9724489116
419PhosphorylationAPILPGQTFTEKFSI
CCCCCCCCCEECCCC		38.1425752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OSH7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OSH7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OSH7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS4_YEASTVPS4physical
16096648
MID2_YEASTMID2physical
18467557
WSC2_YEASTWSC2physical
18467557
FLC1_YEASTFLC1physical
18467557
PDR12_YEASTPDR12physical
18467557
OSH6_YEASTOSH6physical
18467557
TCB3_YEASTTCB3physical
18467557
TPO4_YEASTTPO4physical
18467557
OSH1_YEASTSWH1genetic
11238399
SAC1_YEASTSAC1physical
21295699
KES1_YEASTKES1genetic
21819498
MID2_YEASTMID2physical
22615397
MTC4_YEASTMTC4genetic
23891562
GAS1_YEASTGAS1genetic
23891562
PSD1_YEASTPSD1genetic
23891562
MOB2_YEASTMOB2genetic
27708008
NU192_YEASTNUP192genetic
27708008
THRC_YEASTTHR4genetic
27708008
ODO2_YEASTKGD2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
KPYK1_YEASTCDC19genetic
27708008
CDC24_YEASTCDC24genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
AME1_YEASTAME1genetic
27708008
NOP14_YEASTNOP14genetic
27708008
MAK21_YEASTMAK21genetic
27708008
LCB2_YEASTLCB2genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC1_YEASTCDC1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
SEC20_YEASTSEC20genetic
27708008
GDI1_YEASTGDI1genetic
27708008
SEC4_YEASTSEC4genetic
27708008
ALG2_YEASTALG2genetic
27708008
GPI10_YEASTGPI10genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
OKP1_YEASTOKP1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
RHO3_YEASTRHO3genetic
27708008
EXO70_YEASTEXO70genetic
27708008
GWT1_YEASTGWT1genetic
27708008
PRP21_YEASTPRP21genetic
27708008
UGPA1_YEASTUGP1genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC39_YEASTSEC39genetic
27708008
BET5_YEASTBET5genetic
27708008
PGA3_YEASTPGA3genetic
27708008
MCM1_YEASTMCM1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
APC5_YEASTAPC5genetic
27708008
SEC62_YEASTSEC62genetic
27708008
SKT5_YEASTSKT5genetic
27708008
ECM33_YEASTECM33genetic
27708008
SMY2_YEASTSMY2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CWH43_YEASTCWH43genetic
27708008
YCV1_YEASTYCR061Wgenetic
27708008
GIS1_YEASTGIS1genetic
27708008
ARO1_YEASTARO1genetic
27708008
BEM2_YEASTBEM2genetic
27708008
BCK2_YEASTBCK2genetic
27708008
IES1_YEASTIES1genetic
27708008
COG7_YEASTCOG7genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
GUP1_YEASTGUP1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
PEP8_YEASTPEP8genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
HS150_YEASTHSP150genetic
27708008
NFU1_YEASTNFU1genetic
27708008
MTC2_YEASTMTC2genetic
27708008
DBP7_YEASTDBP7genetic
27708008
CSF1_YEASTCSF1genetic
27708008
COG8_YEASTCOG8genetic
27708008
SWS2_YEASTSWS2genetic
27708008
INO4_YEASTINO4genetic
27708008
2A5D_YEASTRTS1genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
RUD3_YEASTRUD3genetic
27708008
MNE1_YEASTMNE1genetic
27708008
YO378_YEASTAMF1genetic
27708008
ARL3_YEASTARL3genetic
27708008
BEM4_YEASTBEM4genetic
27708008
NIP80_YEASTNIP100genetic
27708008
YME1_YEASTYME1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
BSP1_YEASTBSP1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OSH7_YEAST

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Related Literatures of Post-Translational Modification

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