| UniProt ID | PSD1_YEAST | |
|---|---|---|
| UniProt AC | P39006 | |
| Protein Name | Phosphatidylserine decarboxylase proenzyme 1, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:8227017} | |
| Gene Name | PSD1 {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000303|PubMed:8227017} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 500 | |
| Subcellular Localization |
Phosphatidylserine decarboxylase 1 beta chain: Mitochondrion inner membrane Single-pass membrane protein Intermembrane side . Phosphatidylserine decarboxylase 1 alpha chain: Mitochondrion inner membrane Peripheral membrane protein Intermembrane s |
|
| Protein Description | Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. [PubMed: 8227017] | |
| Protein Sequence | MSIMPVKNALAQGRTLLMGRMPAVKFSTRMQLRNRTAVLWNRKFSTRLFVQQRRSSGEIVDRAKAAAANSGRKQVSMKWVVLTSFTIVLGTILLVSRNDSTEEDATEGKKGRRTRKIKIFNNNWLFFCYSTLPLNAMSRLWGQVNSLTLPIWVRPWGYRLYSFLFGVNLDEMEDPDLTHYANLSEFFYRNIKPGTRPVAQGEDVIASPSDGKILQVGIINSETGEIEQVKGMTYSIKEFLGTHSHPLMSKSASSLDLTSDEEKHREFARVNRIQLAGSEDTEQPLLNFKNEGDQSVREFKPSVSKNIHLLSQLSLNYFSNGFSCSEPHDTELFFAVIYLAPGDYHHFHSPVDWVCKVRRHFPGDLFSVAPYFQRNFPNLFVLNERVALLGSWKYGFFSMTPVGATNVGSIKLNFDQEFVTNSKSDKHLEPHTCYQAVYENASKILGGMPLVKGEEMGGFELGSTVVLCFEAPTEFKFDVRVGDKVKMGQKLGIIGKNDLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 192 | Ubiquitination | EFFYRNIKPGTRPVA HHHHHHCCCCCCCCC | 40.73 | 23749301 | |
| 212 | Ubiquitination | IASPSDGKILQVGII EECCCCCCEEEEEEE | 45.28 | 17644757 | |
| 230 | Ubiquitination | TGEIEQVKGMTYSIK CCCEEEEECCEEEHH | 42.53 | 17644757 | |
| 237 | Ubiquitination | KGMTYSIKEFLGTHS ECCEEEHHHHHCCCC | 36.15 | 17644757 | |
| 250 | Ubiquitination | HSHPLMSKSASSLDL CCCCCCCCCCCCCCC | 35.76 | 17644757 | |
| 251 | Phosphorylation | SHPLMSKSASSLDLT CCCCCCCCCCCCCCC | 26.52 | 22369663 | |
| 253 | Phosphorylation | PLMSKSASSLDLTSD CCCCCCCCCCCCCCC | 38.23 | 22369663 | |
| 254 | Phosphorylation | LMSKSASSLDLTSDE CCCCCCCCCCCCCCH | 26.14 | 22369663 | |
| 259 | Phosphorylation | ASSLDLTSDEEKHRE CCCCCCCCCHHHHHH | 50.77 | 21551504 | |
| 263 | Acetylation | DLTSDEEKHREFARV CCCCCHHHHHHHHCC | 46.01 | 24489116 | |
| 263 | Ubiquitination | DLTSDEEKHREFARV CCCCCHHHHHHHHCC | 46.01 | 17644757 | |
| 289 | Ubiquitination | EQPLLNFKNEGDQSV CCCCCCCCCCCCCCH | 53.68 | 23749301 | |
| 393 | Ubiquitination | VALLGSWKYGFFSMT EEECCCCCCEEEECC | 36.87 | 17644757 | |
| 411 | Ubiquitination | ATNVGSIKLNFDQEF CCCCCCEEEECCHHH | 38.79 | 17644757 | |
| 420 | Phosphorylation | NFDQEFVTNSKSDKH ECCHHHCCCCCCCCC | 38.81 | 27017623 | |
| 422 | Phosphorylation | DQEFVTNSKSDKHLE CHHHCCCCCCCCCCC | 24.95 | 27017623 | |
| 423 | Ubiquitination | QEFVTNSKSDKHLEP HHHCCCCCCCCCCCC | 65.82 | 23749301 | |
| 426 | Acetylation | VTNSKSDKHLEPHTC CCCCCCCCCCCCCCH | 58.12 | 24489116 | |
| 426 | Ubiquitination | VTNSKSDKHLEPHTC CCCCCCCCCCCCCCH | 58.12 | 17644757 | |
| 438 | Phosphorylation | HTCYQAVYENASKIL CCHHHHHHHCHHHHH | 13.38 | 27017623 | |
| 443 | Ubiquitination | AVYENASKILGGMPL HHHHCHHHHHCCCCC | 39.27 | 17644757 | |
| 463 | Pyruvate | MGGFELGSTVVLCFE ECCCCCCCEEEEEEE | 30.56 | - | |
| 463 | Pyruvic acid (Ser) | MGGFELGSTVVLCFE ECCCCCCCEEEEEEE | 30.56 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PSD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PSD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PSD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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