| UniProt ID | PIN4_YEAST | |
|---|---|---|
| UniProt AC | P34217 | |
| Protein Name | RNA-binding protein PIN4 | |
| Gene Name | PIN4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 668 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage.. | |
| Protein Sequence | METSSFENAPPAAINDAQDNNINTETNDQETNQQSIETRDAIDKENGVQTETGENSAKNAEQNVSSTNLNNAPTNGALDDDVIPNAIVIKNIPFAIKKEQLLDIIEEMDLPLPYAFNYHFDNGIFRGLAFANFTTPEETTQVITSLNGKEISGRKLKVEYKKMLPQAERERIEREKREKRGQLEEQHRSSSNLSLDSLSKMSGSGNNNTSNNQLFSTLMNGINANSMMNSPMNNTINNNSSNNNNSGNIILNQPSLSAQHTSSSLYQTNVNNQAQMSTERFYAPLPSTSTLPLPPQQLDFNDPDTLEIYSQLLLFKDREKYYYELAYPMGISASHKRIINVLCSYLGLVEVYDPRFIIIRRKILDHANLQSHLQQQGQMTSAHPLQPNSTGGSMNRSQSYTSLLQAHAAAAANSISNQAVNNSSNSNTINSNNGNGNNVIINNNSASSTPKISSQGQFSMQPTLTSPKMNIHHSSQYNSADQPQQPQPQTQQNVQSAAQQQQSFLRQQATLTPSSRIPSGYSANHYQINSVNPLLRNSQISPPNSQIPINSQTLSQAQPPAQSQTQQRVPVAYQNASLSSQQLYNLNGPSSANSQSQLLPQHTNGSVHSNFSYQSYHDESMLSAHNLNSADLIYKSLSHSGLDDGLEQGLNRSLSGLDLQNQNKKNLW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----METSSFENAP -----CCCCCCCCCC | 28.51 | 30377154 | |
| 5 | Phosphorylation | ---METSSFENAPPA ---CCCCCCCCCCCC | 43.96 | 30377154 | |
| 44 | Ubiquitination | ETRDAIDKENGVQTE HHHHHHHHHCCEECC | 47.14 | 23749301 | |
| 50 | Phosphorylation | DKENGVQTETGENSA HHHCCEECCCCCCHH | 32.86 | 22369663 | |
| 52 | Phosphorylation | ENGVQTETGENSAKN HCCEECCCCCCHHHC | 53.86 | 22369663 | |
| 56 | Phosphorylation | QTETGENSAKNAEQN ECCCCCCHHHCHHHC | 36.00 | 22369663 | |
| 65 | Phosphorylation | KNAEQNVSSTNLNNA HCHHHCCCCCCCCCC | 38.71 | 25521595 | |
| 66 | Phosphorylation | NAEQNVSSTNLNNAP CHHHCCCCCCCCCCC | 19.61 | 25521595 | |
| 67 | Phosphorylation | AEQNVSSTNLNNAPT HHHCCCCCCCCCCCC | 35.90 | 22369663 | |
| 74 | Phosphorylation | TNLNNAPTNGALDDD CCCCCCCCCCCCCCC | 43.82 | 25521595 | |
| 134 | Phosphorylation | GLAFANFTTPEETTQ CCEECCCCCHHHHHH | 41.05 | 22369663 | |
| 135 | Phosphorylation | LAFANFTTPEETTQV CEECCCCCHHHHHHH | 25.27 | 22369663 | |
| 139 | Phosphorylation | NFTTPEETTQVITSL CCCCHHHHHHHHHHC | 22.36 | 22369663 | |
| 140 | Phosphorylation | FTTPEETTQVITSLN CCCHHHHHHHHHHCC | 24.90 | 22369663 | |
| 144 | Phosphorylation | EETTQVITSLNGKEI HHHHHHHHHCCCCEE | 28.45 | 22369663 | |
| 145 | Phosphorylation | ETTQVITSLNGKEIS HHHHHHHHCCCCEEC | 14.55 | 22369663 | |
| 189 | Phosphorylation | QLEEQHRSSSNLSLD HHHHHHHHCCCCCHH | 35.67 | 22369663 | |
| 190 | Phosphorylation | LEEQHRSSSNLSLDS HHHHHHHCCCCCHHH | 24.17 | 22369663 | |
| 191 | Phosphorylation | EEQHRSSSNLSLDSL HHHHHHCCCCCHHHH | 42.93 | 22369663 | |
| 194 | Phosphorylation | HRSSSNLSLDSLSKM HHHCCCCCHHHHHCC | 34.09 | 22369663 | |
| 197 | Phosphorylation | SSNLSLDSLSKMSGS CCCCCHHHHHCCCCC | 39.57 | 22369663 | |
| 199 | Phosphorylation | NLSLDSLSKMSGSGN CCCHHHHHCCCCCCC | 30.20 | 22369663 | |
| 262 | Phosphorylation | SLSAQHTSSSLYQTN CCCCCCCCCCCEECC | 18.79 | 28889911 | |
| 305 | Phosphorylation | LDFNDPDTLEIYSQL CCCCCHHHHHHHHHH | 31.51 | 19823750 | |
| 309 | Phosphorylation | DPDTLEIYSQLLLFK CHHHHHHHHHHHHHC | 4.87 | 19795423 | |
| 310 | Phosphorylation | PDTLEIYSQLLLFKD HHHHHHHHHHHHHCC | 21.73 | 19795423 | |
| 320 | Acetylation | LLFKDREKYYYELAY HHHCCHHHHHHHHHC | 39.17 | 24489116 | |
| 321 | Phosphorylation | LFKDREKYYYELAYP HHCCHHHHHHHHHCC | 13.41 | 30377154 | |
| 322 | Phosphorylation | FKDREKYYYELAYPM HCCHHHHHHHHHCCC | 11.09 | 30377154 | |
| 327 | Phosphorylation | KYYYELAYPMGISAS HHHHHHHCCCCCCCC | 13.33 | 30377154 | |
| 332 | Phosphorylation | LAYPMGISASHKRII HHCCCCCCCCHHHHH | 20.28 | 30377154 | |
| 371 | Phosphorylation | LDHANLQSHLQQQGQ HHHHHHHHHHHHCCC | 29.36 | 28889911 | |
| 389 | Phosphorylation | AHPLQPNSTGGSMNR CCCCCCCCCCCCCCC | 34.80 | 17330950 | |
| 390 | Phosphorylation | HPLQPNSTGGSMNRS CCCCCCCCCCCCCCC | 52.80 | 23607784 | |
| 393 | Phosphorylation | QPNSTGGSMNRSQSY CCCCCCCCCCCCHHH | 17.77 | 23607784 | |
| 397 | Phosphorylation | TGGSMNRSQSYTSLL CCCCCCCCHHHHHHH | 20.62 | 28889911 | |
| 399 | Phosphorylation | GSMNRSQSYTSLLQA CCCCCCHHHHHHHHH | 31.46 | 28889911 | |
| 400 | Phosphorylation | SMNRSQSYTSLLQAH CCCCCHHHHHHHHHH | 7.85 | 28889911 | |
| 402 | Phosphorylation | NRSQSYTSLLQAHAA CCCHHHHHHHHHHHH | 20.89 | 28889911 | |
| 453 | Phosphorylation | ASSTPKISSQGQFSM CCCCCCCCCCCCCCC | 23.80 | 22890988 | |
| 454 | Phosphorylation | SSTPKISSQGQFSMQ CCCCCCCCCCCCCCC | 41.63 | 22890988 | |
| 459 | Phosphorylation | ISSQGQFSMQPTLTS CCCCCCCCCCCCCCC | 14.50 | 21440633 | |
| 463 | Phosphorylation | GQFSMQPTLTSPKMN CCCCCCCCCCCCCCC | 26.27 | 22890988 | |
| 465 | Phosphorylation | FSMQPTLTSPKMNIH CCCCCCCCCCCCCCC | 45.52 | 25521595 | |
| 466 | Phosphorylation | SMQPTLTSPKMNIHH CCCCCCCCCCCCCCC | 26.15 | 22369663 | |
| 510 | Phosphorylation | SFLRQQATLTPSSRI HHHHHHCCCCCHHCC | 27.16 | 22369663 | |
| 512 | Phosphorylation | LRQQATLTPSSRIPS HHHHCCCCCHHCCCC | 19.44 | 22369663 | |
| 514 | Phosphorylation | QQATLTPSSRIPSGY HHCCCCCHHCCCCCC | 27.32 | 22369663 | |
| 515 | Phosphorylation | QATLTPSSRIPSGYS HCCCCCHHCCCCCCC | 35.12 | 24909858 | |
| 519 | Phosphorylation | TPSSRIPSGYSANHY CCHHCCCCCCCCCCE | 48.25 | 22369663 | |
| 521 | Phosphorylation | SSRIPSGYSANHYQI HHCCCCCCCCCCEEE | 14.67 | 22369663 | |
| 522 | Phosphorylation | SRIPSGYSANHYQIN HCCCCCCCCCCEEEC | 26.56 | 21440633 | |
| 526 | Phosphorylation | SGYSANHYQINSVNP CCCCCCCEEECCCCH | 15.76 | 22369663 | |
| 530 | Phosphorylation | ANHYQINSVNPLLRN CCCEEECCCCHHHHC | 25.54 | 22369663 | |
| 538 | Phosphorylation | VNPLLRNSQISPPNS CCHHHHCCCCCCCCC | 23.58 | 22369663 | |
| 541 | Phosphorylation | LLRNSQISPPNSQIP HHHCCCCCCCCCCCC | 27.03 | 22369663 | |
| 545 | Phosphorylation | SQISPPNSQIPINSQ CCCCCCCCCCCCCCC | 34.95 | 22369663 | |
| 551 | Phosphorylation | NSQIPINSQTLSQAQ CCCCCCCCCCHHCCC | 25.84 | 23749301 | |
| 553 | Phosphorylation | QIPINSQTLSQAQPP CCCCCCCCHHCCCCC | 28.35 | 22369663 | |
| 555 | Phosphorylation | PINSQTLSQAQPPAQ CCCCCCHHCCCCCCC | 27.19 | 23749301 | |
| 563 | Phosphorylation | QAQPPAQSQTQQRVP CCCCCCCCCCCCCCC | 36.98 | 22369663 | |
| 565 | Phosphorylation | QPPAQSQTQQRVPVA CCCCCCCCCCCCCCE | 31.73 | 22369663 | |
| 579 | Phosphorylation | AYQNASLSSQQLYNL EEECCCCCHHHHHCC | 24.49 | 28889911 | |
| 629 | Phosphorylation | LSAHNLNSADLIYKS HHHCCCCHHHHHHHH | 26.73 | 28889911 | |
| 636 | Phosphorylation | SADLIYKSLSHSGLD HHHHHHHHHCCCCCC | 20.38 | 22369663 | |
| 638 | Phosphorylation | DLIYKSLSHSGLDDG HHHHHHHCCCCCCHH | 23.77 | 22369663 | |
| 640 | Phosphorylation | IYKSLSHSGLDDGLE HHHHHCCCCCCHHHH | 37.36 | 22369663 | |
| 653 | Phosphorylation | LEQGLNRSLSGLDLQ HHHHHHHHHCCCCCC | 26.30 | 22369663 | |
| 655 | Phosphorylation | QGLNRSLSGLDLQNQ HHHHHHHCCCCCCCC | 38.26 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 305 | T | Phosphorylation | Kinase | ATR | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIN4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIN4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-65; SER-190;SER-191; SER-194; SER-197; SER-199; SER-262; SER-397; SER-399;TYR-400; SER-402; SER-454; SER-466; TYR-526; SER-579; SER-629;SER-636; SER-638; SER-640; SER-653 AND SER-655, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-194; SER-636;SER-638; SER-640; SER-653 AND SER-655, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND SER-190, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND SER-466, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-541; SER-638AND SER-655, AND MASS SPECTROMETRY. | |
