ATG32_YEAST - dbPTM
ATG32_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG32_YEAST
UniProt AC P40458
Protein Name Autophagy-related protein 32
Gene Name ATG32
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 529
Subcellular Localization Mitochondrion outer membrane
Single-pass membrane protein. Vacuole membrane
Single-pass membrane protein. Preautophagosomal structure membrane
Single-pass membrane protein. Is recruited to the preautophagosomal structure during mitophagy and impor
Protein Description Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation..
Protein Sequence MVLEYQQREGKGSSSKSMPPDSSSTTIHTCSEAQTGEDKGLLDPHLSVLELLSKTGHSPSPMGQNLVTSIDISGNHNVNDSISGSWQAIQPLDLGASFIPERCSSQTTNGSILSSSDTSEEEQELLQAPAADIINIIKQGQEGANVVSPSHPFKQLQKIISLPLPGKEKTPFNEQDDDGDEDEAFEEDSVTITKSLTSSTNSFVMPKLSLTQKNPVFRLLILGRTGSSFYQSIPKEYQSLFELPKYHDSATFPQYTGIVIIFQELREMVSLLNRIVQYSQGKPVIPICQPGQVIQVKNVLKSFLRNKLVKLLFPPVVVTNKRDLKKMFQRLQDLSLEYGEDVNEEDNDDEAIHTKSRSYCRNKKAENSKKKSPKSNKKPKRKKQKFFTSWFTWGISITIGISFGCCVTYFVTAAYEHQTVKSLSLRPSILASLLSLDSSSDTINTPATASPSSTEQFLWFDKGTLQINFHSDGFIMKSLTIIKETWGKMNTFVLHALSKPLKFLENLNKSSEFSIDESNRILALGYILL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationGKGSSSKSMPPDSSS
CCCCCCCCCCCCCCC		38.1727017623
31PhosphorylationSTTIHTCSEAQTGED
CCEEEECCCCCCCCC		36.8027017623
35PhosphorylationHTCSEAQTGEDKGLL
EECCCCCCCCCCCCC		49.9727017623
114PhosphorylationTTNGSILSSSDTSEE
CCCCCCCCCCCCCHH		26.5728889911
119PhosphorylationILSSSDTSEEEQELL
CCCCCCCCHHHHHHH		48.2628889911
148PhosphorylationQEGANVVSPSHPFKQ
CCCCCCCCCCCHHHH		19.1923749301
161PhosphorylationKQLQKIISLPLPGKE
HHHHHHHCCCCCCCC		27.6628152593
199PhosphorylationITKSLTSSTNSFVMP
EEEHHHCCCCCEECC		26.7727214570
200PhosphorylationTKSLTSSTNSFVMPK
EEHHHCCCCCEECCC		34.3524961812
202PhosphorylationSLTSSTNSFVMPKLS
HHHCCCCCEECCCCC		21.2127214570
335PhosphorylationFQRLQDLSLEYGEDV
HHHHHHHHHHHCCCC		27.6927017623
358PhosphorylationAIHTKSRSYCRNKKA
HHHHHHHHHHHCHHH		35.3627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG32_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
114SPhosphorylation

21757540
119SPhosphorylation

21757540
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG32_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG8_YEASTATG8physical
19619494
ATG11_YEASTATG11physical
19619494
ATG11_YEASTATG11physical
21757540
ATG8_YEASTATG8physical
22308029
ATG11_YEASTATG11physical
22308029
HSP71_YEASTSSA1physical
22940862
YME1_YEASTYME1physical
24025448
ATG11_YEASTATG11physical
24025448
CCZ1_YEASTCCZ1genetic
24586198
ATG11_YEASTATG11physical
23810512
ATG8_YEASTATG8physical
26296886
ATG11_YEASTATG11physical
26296886
CSK21_YEASTCKA1physical
23897086
ATG11_YEASTATG11physical
23897086
CSK2B_YEASTCKB1physical
23897086
TBS1_YEASTTBS1genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
RBSK_YEASTRBK1genetic
27708008
PHM6_YEASTPHM6genetic
27708008
KEX1_YEASTKEX1genetic
27708008
YMB8_YEASTYML018Cgenetic
27708008
PSK1_YEASTPSK1genetic
27708008
GAL7_YEASTGAL7genetic
27708008
BAP2_YEASTBAP2genetic
27708008
ADPP_YEASTYSA1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
PBP2_YEASTPBP2genetic
27708008
CSM1_YEASTCSM1genetic
27708008
PUS9_YEASTPUS9genetic
27708008
GDIR_YEASTRDI1genetic
27708008
SERA_YEASTSER3genetic
27708008
RRT5_YEASTRRT5genetic
27708008
TYW3_YEASTTYW3genetic
27708008
HUL5_YEASTHUL5genetic
27708008
SPR3_YEASTSPR3genetic
27708008
PBP1_YEASTPBP1genetic
27708008
SOL4_YEASTSOL4genetic
27708008
YOR1_YEASTYOR1genetic
27708008
AIM17_YEASTAIM17genetic
27708008
STP2_YEASTSTP2genetic
27708008
SODM_YEASTSOD2genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
NVJ1_YEASTNVJ1genetic
27708008
ALB1_YEASTALB1genetic
27708008
RSF2_YEASTRSF2genetic
27708008
PXA2_YEASTPXA2genetic
27708008
EMP46_YEASTEMP46genetic
27708008
TO6BL_YEASTREC102genetic
27708008
LSM7_YEASTLSM7genetic
27708008
PHM7_YEASTPHM7genetic
27708008
HMI1_YEASTHMI1genetic
27708008
RMI1_YEASTRMI1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG32_YEAST

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Related Literatures of Post-Translational Modification

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