HUL5_YEAST - dbPTM
HUL5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HUL5_YEAST
UniProt AC P53119
Protein Name Probable E3 ubiquitin-protein ligase HUL5
Gene Name HUL5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 910
Subcellular Localization
Protein Description Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Non essential..
Protein Sequence MLNFTGQTRRRNVNLGNRTRNSKKDLLEKAKRERERRAQDKLKEDASKTIQKSIRRHFSNVRLFKNTFTSSQLVHMIPAYGGKLIYYISQYDLQQLLKLSHNFLSSYPNSLGNRQLLSLLKLYQDDALVAETLSDLNMDCPTVDEFLDSLSVYLCRASFLSYSSASKLADVIEAWEVMHSSASISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSHCSKGGQKNIAKLLIPNFNNHIAPSVLRSDNDYVLKFYEKAFIDEVIATTANYVSDEDHVKNLMCYIASSPNQSCKNSVLITLLSNKDFVRRLSWEFFHTKFNASKTEAHPLFSVLAQLIDMHLLISTDRELLDYNSVIPIEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEYEDLYREHLEEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISRDNVLEDAFNAFNSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLNFTGQT
-------CCCCCCCC		6.6122814378
24AcetylationNRTRNSKKDLLEKAK
CCCCCCHHHHHHHHH		54.1223572591
31AcetylationKDLLEKAKRERERRA
HHHHHHHHHHHHHHH		66.9023572591
47PhosphorylationDKLKEDASKTIQKSI
HHHHHHHHHHHHHHH		42.5328889911
53PhosphorylationASKTIQKSIRRHFSN
HHHHHHHHHHHHHCC		12.6428889911
244UbiquitinationGGQKNIAKLLIPNFN
CCCCCHHHHHCCCCC		39.7817644757
272UbiquitinationYVLKFYEKAFIDEVI
HHHHHHHHHCHHHHH		36.9017644757
293UbiquitinationVSDEDHVKNLMCYIA
CCCHHHHHHHHHHHH		40.7317644757
308UbiquitinationSSPNQSCKNSVLITL
CCCCHHCCCHHHEEH		58.4617644757
319UbiquitinationLITLLSNKDFVRRLS
HEEHHCCHHHHHHHC		49.5217644757
411PhosphorylationKEAVPLLSKVYERDS
HHHHHHHHHHHHHCC		27.9719795423
437UbiquitinationTYWENSEKQFLNLRF
CCCCCCHHHHHHHHH		46.2817644757
463PhosphorylationREHLEEESDEDMEKE
HHHHHHCCCHHHHHH		49.9728889911
628PhosphorylationLFRTNDRYELYPSVV
CCCCCCCEECCCHHH		17.1030377154
631PhosphorylationTNDRYELYPSVVYDA
CCCCEECCCHHHEEC		4.9830377154
636PhosphorylationELYPSVVYDATKLKY
ECCCHHHEECCHHHH		9.5630377154
639PhosphorylationPSVVYDATKLKYIWF
CHHHEECCHHHHHHH		33.7330377154
869UbiquitinationIRNAGTEKYRLPTAS
CCCCCCCCCCCCCHH		35.1917644757
883UbiquitinationSTCVNLLKLPDYRNK
HHHHHHHCCCCCCCC		62.2317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HUL5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HUL5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HUL5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUF2_YEASTNUF2physical
18467557
OAF3_YEASTOAF3physical
18719252
TPS2_YEASTTPS2genetic
27708008
HRB1_YEASTHRB1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
ODO2_YEASTKGD2genetic
27708008
RPA14_YEASTRPA14genetic
27708008
SEM1_YEASTSEM1genetic
27708008
AVT7_YEASTAVT7genetic
27708008
CYT2_YEASTCYT2genetic
27708008
MTC2_YEASTMTC2genetic
27708008
CTK1_YEASTCTK1genetic
27708008
BPT1_YEASTBPT1genetic
27708008
ADY4_YEASTADY4genetic
27708008
TSR2_YEASTTSR2genetic
27708008
CYB5_YEASTCYB5genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
VPS68_YEASTVPS68genetic
27708008
CHL1_YEASTCHL1genetic
27708008
YP147_YEASTYPR147Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HUL5_YEAST

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Related Literatures of Post-Translational Modification

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