COQ2_YEAST - dbPTM
COQ2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COQ2_YEAST
UniProt AC P32378
Protein Name 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000305}
Gene Name COQ2 {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000303|PubMed:1740455}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 372
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein
Matrix side .
Protein Description Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate..
Protein Sequence MFIWQRKSILLGRSILGSGRVTVAGIIGSSRKRYTSSSSSSSSPSSKESAPVFTSKELEVARKERLDGLGPFVSRLPKKWIPYAELMRLEKPVGTWLLYLPCSWSILMGAMMQGATLSATAGMLGIFGVGALVMRGAGCTINDFLDRKLDQRVIRSVERPIASGRVSPRRALVFLGAQTLVGMGVLSLLPAQCWWLGLASLPIVFTYPLFKRFTYYPQAALSACFNWGALLGFPAMGVMSWPTMIPLYLSSYLWCMTYDTIYAHQDKKFDIKAGIKSTALAWGPRTKSIMKAMSASQIALLAVAGLNSGLLWGPGFIGGLGVFAYRLFSMIKKVDLDNPKNCWKYFNANINTGLYFTYALAVDYILRLFGFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationKSILLGRSILGSGRV
CHHHHCCCHHCCCEE
21.9922890988
18PhosphorylationLGRSILGSGRVTVAG
HCCCHHCCCEEEEEE
21.7122890988
22PhosphorylationILGSGRVTVAGIIGS
HHCCCEEEEEEEECC
11.8622890988
29PhosphorylationTVAGIIGSSRKRYTS
EEEEEECCCCCEECC
19.3022890988
30PhosphorylationVAGIIGSSRKRYTSS
EEEEECCCCCEECCC
36.2922890988
47UbiquitinationSSSSPSSKESAPVFT
CCCCCCCCCCCCCCC
61.0923749301
140PhosphorylationVMRGAGCTINDFLDR
HHCCCCCCHHHHHHH
23.1528889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COQ2_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COQ2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COQ2_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CALX_YEASTCNE1genetic
20093466
FLO1_YEASTFLO1genetic
20093466
UBX3_YEASTUBX3genetic
20093466
SPO71_YEASTSPO71genetic
20093466
EMI1_YEASTEMI1genetic
20093466
GLRX2_YEASTGRX2genetic
20093466
PTP3_YEASTPTP3genetic
20093466
FET5_YEASTFET5genetic
20093466
PMT6_YEASTPMT6genetic
20093466
ENO1_YEASTENO1genetic
20093466
LAM1_YEASTYSP1genetic
20093466
VID28_YEASTVID28genetic
20093466
YJH0_YEASTYJL070Cgenetic
20093466
GYP6_YEASTGYP6genetic
20093466
LTHAD_YEASTSRY1genetic
20093466
TOF2_YEASTTOF2genetic
20093466
APTH1_YEASTYLR118Cgenetic
20093466
UPS1_YEASTUPS1genetic
20093466
RCO1_YEASTRCO1genetic
20093466
CIK1_YEASTCIK1genetic
20093466
RAD14_YEASTRAD14genetic
20093466
IRA2_YEASTIRA2genetic
20093466
PDE2_YEASTPDE2genetic
20093466
TYW1_YEASTTYW1genetic
20093466
DDC1_YEASTDDC1genetic
20093466
CTI6_YEASTCTI6genetic
20093466
YP162_YEASTYPL162Cgenetic
20093466
PET20_YEASTPET20genetic
20093466
YP109_YEASTYPL109Cgenetic
20093466
RAD1_YEASTRAD1genetic
20093466
ZDS1_YEASTZDS1genetic
20345901
2A5D_YEASTRTS1genetic
20345901
ELP1_YEASTIKI3genetic
20345901
ELP4_YEASTELP4genetic
20345901
QCR9_YEASTQCR9genetic
20345901
ACON_YEASTACO1genetic
20345901
MDL2_YEASTMDL2genetic
20345901
SAC1_YEASTSAC1genetic
20345901
SWF1_YEASTSWF1genetic
20345901
ARV1_YEASTARV1genetic
20345901
CDC10_YEASTCDC10genetic
20345901
KCS1_YEASTKCS1genetic
20345901
EMI1_YEASTEMI1genetic
20345901
MET18_YEASTMET18genetic
20345901
RL31A_YEASTRPL31Agenetic
20345901
H2A1_YEASTHTA1genetic
20345901
ADH3_YEASTADH3genetic
21623372
ELO2_YEASTELO2genetic
21623372
METX_YEASTYML082Wgenetic
21623372
CBS_YEASTCYS4genetic
21623372
CYS3_YEASTCYS3genetic
21623372
PDE2_YEASTPDE2genetic
21623372
ADK_YEASTADO1genetic
21623372
IPYR_YEASTIPP1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
NSE3_YEASTNSE3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
MCE1_YEASTCEG1genetic
27708008
ESP1_YEASTESP1genetic
27708008
ORC6_YEASTORC6genetic
27708008
GRP78_YEASTKAR2genetic
27708008
DPB11_YEASTDPB11genetic
27708008
TIM16_YEASTPAM16genetic
27708008
NOP56_YEASTNOP56genetic
27708008
GSP1_YEASTGSP1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
GPI12_YEASTGPI12genetic
27708008
CLP1_YEASTCLP1genetic
27708008
HSP71_YEASTSSA1genetic
27708008
FLO1_YEASTFLO1genetic
27708008
RV161_YEASTRVS161genetic
27708008
GPR1_YEASTGPR1genetic
27708008
CRD1_YEASTCRD1genetic
27708008
AIM6_YEASTAIM6genetic
27708008
ENO1_YEASTENO1genetic
27708008
KTR7_YEASTKTR7genetic
27708008
PMA2_YEASTPMA2genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
YP162_YEASTYPL162Cgenetic
27708008
CTI6_YEASTCTI6genetic
27708008
CISY3_YEASTCIT3genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COQ2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, AND MASSSPECTROMETRY.

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