UniProt ID | COQ2_YEAST | |
---|---|---|
UniProt AC | P32378 | |
Protein Name | 4-hydroxybenzoate polyprenyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000305} | |
Gene Name | COQ2 {ECO:0000255|HAMAP-Rule:MF_03189, ECO:0000303|PubMed:1740455} | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 372 | |
Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein Matrix side . |
|
Protein Description | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.. | |
Protein Sequence | MFIWQRKSILLGRSILGSGRVTVAGIIGSSRKRYTSSSSSSSSPSSKESAPVFTSKELEVARKERLDGLGPFVSRLPKKWIPYAELMRLEKPVGTWLLYLPCSWSILMGAMMQGATLSATAGMLGIFGVGALVMRGAGCTINDFLDRKLDQRVIRSVERPIASGRVSPRRALVFLGAQTLVGMGVLSLLPAQCWWLGLASLPIVFTYPLFKRFTYYPQAALSACFNWGALLGFPAMGVMSWPTMIPLYLSSYLWCMTYDTIYAHQDKKFDIKAGIKSTALAWGPRTKSIMKAMSASQIALLAVAGLNSGLLWGPGFIGGLGVFAYRLFSMIKKVDLDNPKNCWKYFNANINTGLYFTYALAVDYILRLFGFL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
14 | Phosphorylation | KSILLGRSILGSGRV CHHHHCCCHHCCCEE | 21.99 | 22890988 | |
18 | Phosphorylation | LGRSILGSGRVTVAG HCCCHHCCCEEEEEE | 21.71 | 22890988 | |
22 | Phosphorylation | ILGSGRVTVAGIIGS HHCCCEEEEEEEECC | 11.86 | 22890988 | |
29 | Phosphorylation | TVAGIIGSSRKRYTS EEEEEECCCCCEECC | 19.30 | 22890988 | |
30 | Phosphorylation | VAGIIGSSRKRYTSS EEEEECCCCCEECCC | 36.29 | 22890988 | |
47 | Ubiquitination | SSSSPSSKESAPVFT CCCCCCCCCCCCCCC | 61.09 | 23749301 | |
140 | Phosphorylation | VMRGAGCTINDFLDR HHCCCCCCHHHHHHH | 23.15 | 28889911 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COQ2_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COQ2_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COQ2_YEAST !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, AND MASSSPECTROMETRY. |