PMT6_YEAST - dbPTM
PMT6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PMT6_YEAST
UniProt AC P42934
Protein Name Dolichyl-phosphate-mannose--protein mannosyltransferase 6 {ECO:0000305}
Gene Name PMT6 {ECO:0000312|SGD:S000003431}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 759
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins..
Protein Sequence MSKAKGTGFSSIDTEDENLRERYVNQPKANASDIQDEQLDCFEQLEEKHRTKKNEEYTALKILRDVIGPLLLTITSFYLRFQHIDQNNYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKMLIALSEWMAGFDGQFDFSSNNAYPENVNFKLMRQFNATFGALCTPVAFFTAKWMGFNYFTVYLIATMVTLEHSYIVLSKFILLDSMLLFFSMTTFACMIKLYTLRKQQMTKKWSLWMLLTGLSIGCVCSVKWVGLFITVVVGLYTCIELFLLYCDKELPRIKYYKHWLIRIINLIVIPFLIYLYCFKIHFVLLYKSGTGDSTTNTLFQINLEGTQIEAGPRDVAFGSELTIRSHGLSPNLLHSHIQVYPEGSGQRQITGYGFADSNNVWKFEFSRSSGLELDQNGTLNGKIIPITDGVEVRLSHKNTGSNLHSHDVPSHVSRGNYEVSGYGSQSVGDEKDDWIVEIVKQMDSPNPVYSNENSTILHPVSTFFRLRHKVLGCYLASTGLTYPAWGFKQAEIVCKDSWSRRDKSTWWNVEDHWNHNLETAEDYVPPKSNFWTDFILTNFAMASSNNALVPDEDKYDSLSSDAWEWPTLHKGLRMCSWAGYITRYYLMGSPFNTWISTVSLIIFPFIILFILYRWRRQTLYLSDDQIWQITIQGIFPFISWMTHYLPFAMMGRVTYVHHYVPALYFAMLVFGFVLDFTLTRVHWMVKYPIYLSLFGGCIYIYNLFAPICQGMHGDKAEYLPLQWLSTWDIAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSKAKGTGF
------CCCCCCCCC		41.1222814378
10PhosphorylationKAKGTGFSSIDTEDE
CCCCCCCCCCCCCCH		27.9422369663
11PhosphorylationAKGTGFSSIDTEDEN
CCCCCCCCCCCCCHH		23.4022369663
14PhosphorylationTGFSSIDTEDENLRE
CCCCCCCCCCHHHHH		43.6022369663
32PhosphorylationNQPKANASDIQDEQL
CCCCCCHHHCCHHHH		34.7523749301
156N-linked_GlycosylationFKLMRQFNATFGALC
HHHHHHHCCHHHHCC		29.72-
321PhosphorylationYKSGTGDSTTNTLFQ
ECCCCCCCCCCEEEE		38.1827017623
322PhosphorylationKSGTGDSTTNTLFQI
CCCCCCCCCCEEEEE		28.8927017623
323PhosphorylationSGTGDSTTNTLFQIN
CCCCCCCCCEEEEEE		30.1127017623
404N-linked_GlycosylationSGLELDQNGTLNGKI
CCCEECCCCCCCCEE		45.12-
481N-linked_GlycosylationNPVYSNENSTILHPV
CCCCCCCCCCCCCCH		49.02-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PMT6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PMT6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PMT6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PMT2_YEASTPMT2genetic
16269340
PSD2_YEASTPSD2genetic
16269340
YPS7_YEASTYPS7genetic
16269340
GCS1_YEASTGCS1genetic
16269340
PFD4_YEASTGIM3genetic
16269340
ARF1_YEASTARF1genetic
16269340
COPE_YEASTSEC28genetic
16269340
BFR1_YEASTBFR1genetic
16269340
GET1_YEASTGET1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
PMT2_YEASTPMT2genetic
20093466
GAL7_YEASTGAL7genetic
20093466
RL4A_YEASTRPL4Agenetic
20093466
SHE3_YEASTSHE3genetic
20093466
SWD3_YEASTSWD3genetic
20093466
RGD1_YEASTRGD1genetic
20093466
PHO89_YEASTPHO89genetic
20093466
MRC1_YEASTMRC1genetic
20093466
DCC1_YEASTDCC1genetic
20093466
PHO87_YEASTPHO87genetic
20093466
RL41A_YEASTRPL41Agenetic
20093466
RL41B_YEASTRPL41Agenetic
20093466
RLA3_YEASTRPP1Bgenetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
MRX9_YEASTYDL027Cgenetic
20093466
UBC13_YEASTUBC13genetic
20093466
UBP3_YEASTUBP3genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
PALF_YEASTRIM8genetic
20093466
PACC_YEASTRIM101genetic
20093466
YH10_YEASTYHR210Cgenetic
20093466
3HAO_YEASTBNA1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
LHS1_YEASTLHS1genetic
20093466
PAN3_YEASTPAN3genetic
20093466
TVP38_YEASTTVP38genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
BUD8_YEASTBUD8genetic
20093466
TSL1_YEASTTSL1genetic
20093466
MKS1_YEASTMKS1genetic
20093466
COQ2_YEASTCOQ2genetic
20093466
PALA_YEASTRIM20genetic
20093466
RPN12_YEASTRPN12genetic
27708008
TECR_YEASTTSC13genetic
27708008
CDC37_YEASTCDC37genetic
27708008
SEC7_YEASTSEC7genetic
27708008
SNU56_YEASTSNU56genetic
27708008
STS1_YEASTSTS1genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
POB3_YEASTPOB3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
APC5_YEASTAPC5genetic
27708008
TBF1_YEASTTBF1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PMT2_YEASTPMT2genetic
27708008
GAL7_YEASTGAL7genetic
27708008
SHE3_YEASTSHE3genetic
27708008
NPL4_YEASTNPL4genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RV161_YEASTRVS161genetic
27708008
PHO87_YEASTPHO87genetic
27708008
MRX9_YEASTYDL027Cgenetic
27708008
RL41A_YEASTRPL41Agenetic
27708008
RL41B_YEASTRPL41Agenetic
27708008
RV167_YEASTRVS167genetic
27708008
UBP3_YEASTUBP3genetic
27708008
BUD27_YEASTBUD27genetic
27708008
MRM2_YEASTMRM2genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
PTH_YEASTPTH1genetic
27708008
YH10_YEASTYHR210Cgenetic
27708008
PEX2_YEASTPEX2genetic
27708008
3HAO_YEASTBNA1genetic
27708008
HIR3_YEASTHIR3genetic
27708008
TVP38_YEASTTVP38genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
BUD8_YEASTBUD8genetic
27708008
TSL1_YEASTTSL1genetic
27708008
MAC1_YEASTMAC1genetic
27708008
PET8_YEASTPET8genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
CY1_YEASTCYT1genetic
27708008
PALA_YEASTRIM20genetic
27708008
RU2A_YEASTLEA1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PMT6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, AND MASSSPECTROMETRY.

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