| UniProt ID | BFR1_YEAST | |
|---|---|---|
| UniProt AC | P38934 | |
| Protein Name | Nuclear segregation protein BFR1 | |
| Gene Name | BFR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 470 | |
| Subcellular Localization | ||
| Protein Description | Implicated in secretion, nuclear segregation and in maintenance of cell size.. | |
| Protein Sequence | MSSQQHKFKRPDVSVRDKKLDTLNVQLKKIDTEIGLIRKQIDQHQVNDTTQQERKKLQDKNKEIIKIQADLKTRRSNIHDSIKQLDAQIKRKNNQIEEKLGKKAKFSSTAEAKQRINEIEESIASGDLSLVQEKLLVKEMQSLNKLIKDLVNIEPIRKSVDADKAKINQLKEELNGLNPKDVSNQFEENQQKLNDIHSKTQGVYDKRQTLFNKRAALYKKRDELYSQIRQIRADFDNEFKSFRAKLDKERLKREEEQRLSKLLEQKDVDMGKLQEKLTHAKIPAFTYEIGAIENSLLVLDPTYVKPKKNILPDLSSNALETKPARKVVADDLVLVTPKKDDFVNVAPSKSKKYKKKNQQKNTENEQPASIFNKVDGKFTLEPTLIATLAELDVTVPINSDDVKITVEQLKKKHEELLSKQEEQTKQNIESVEKEIEKLNLDYSNKEQQVKKELEEKRLKEQEESEKDKEN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MSSQQHKFKRPDVS -CCCCCCCCCCCCCC | 48.52 | 25381059 | |
| 9 | Acetylation | SSQQHKFKRPDVSVR CCCCCCCCCCCCCHH | 68.75 | 25381059 | |
| 18 | Acetylation | PDVSVRDKKLDTLNV CCCCHHHCCCCHHHH | 44.67 | 24489116 | |
| 29 | Ubiquitination | TLNVQLKKIDTEIGL HHHHHHHHHHHHHHH | 55.17 | 24961812 | |
| 32 | Phosphorylation | VQLKKIDTEIGLIRK HHHHHHHHHHHHHHH | 32.73 | 22369663 | |
| 39 | Ubiquitination | TEIGLIRKQIDQHQV HHHHHHHHHHHHHCC | 44.61 | 24961812 | |
| 39 | Acetylation | TEIGLIRKQIDQHQV HHHHHHHHHHHHHCC | 44.61 | 25381059 | |
| 49 | Phosphorylation | DQHQVNDTTQQERKK HHHCCCHHHHHHHHH | 22.69 | 28889911 | |
| 66 | Acetylation | DKNKEIIKIQADLKT HHCHHHHHHHHHHHH | 34.13 | 24489116 | |
| 72 | Acetylation | IKIQADLKTRRSNIH HHHHHHHHHCHHCHH | 40.30 | 24489116 | |
| 73 | Phosphorylation | KIQADLKTRRSNIHD HHHHHHHHCHHCHHH | 38.32 | 29136822 | |
| 76 | Phosphorylation | ADLKTRRSNIHDSIK HHHHHCHHCHHHHHH | 36.52 | 29136822 | |
| 81 | Phosphorylation | RRSNIHDSIKQLDAQ CHHCHHHHHHHHHHH | 19.95 | 30377154 | |
| 83 | Acetylation | SNIHDSIKQLDAQIK HCHHHHHHHHHHHHH | 49.08 | 24489116 | |
| 90 | Succinylation | KQLDAQIKRKNNQIE HHHHHHHHHHHHHHH | 45.28 | 23954790 | |
| 99 | Acetylation | KNNQIEEKLGKKAKF HHHHHHHHHCCCCCC | 50.15 | 25381059 | |
| 105 | Acetylation | EKLGKKAKFSSTAEA HHHCCCCCCCCHHHH | 55.44 | 24489116 | |
| 113 | Ubiquitination | FSSTAEAKQRINEIE CCCHHHHHHHHHHHH | 31.45 | 23749301 | |
| 113 | Acetylation | FSSTAEAKQRINEIE CCCHHHHHHHHHHHH | 31.45 | 25381059 | |
| 113 | Succinylation | FSSTAEAKQRINEIE CCCHHHHHHHHHHHH | 31.45 | 23954790 | |
| 138 | Acetylation | VQEKLLVKEMQSLNK HHHHHHHHHHHHHHH | 47.65 | 24489116 | |
| 145 | Acetylation | KEMQSLNKLIKDLVN HHHHHHHHHHHHHCC | 57.81 | 24489116 | |
| 148 | Acetylation | QSLNKLIKDLVNIEP HHHHHHHHHHCCCHH | 56.28 | 24489116 | |
| 158 | Acetylation | VNIEPIRKSVDADKA CCCHHHCCCCCCCHH | 56.39 | 24489116 | |
| 159 | Phosphorylation | NIEPIRKSVDADKAK CCHHHCCCCCCCHHH | 18.51 | 28152593 | |
| 164 | Acetylation | RKSVDADKAKINQLK CCCCCCCHHHHHHHH | 53.99 | 24489116 | |
| 171 | Acetylation | KAKINQLKEELNGLN HHHHHHHHHHHCCCC | 39.10 | 24489116 | |
| 180 | Acetylation | ELNGLNPKDVSNQFE HHCCCCHHHHHHHHH | 70.46 | 24489116 | |
| 183 | Phosphorylation | GLNPKDVSNQFEENQ CCCHHHHHHHHHHHH | 34.74 | 30377154 | |
| 192 | Acetylation | QFEENQQKLNDIHSK HHHHHHHHHHHHHHH | 39.22 | 24489116 | |
| 198 | Phosphorylation | QKLNDIHSKTQGVYD HHHHHHHHHHCCHHH | 37.42 | 28889911 | |
| 199 | Acetylation | KLNDIHSKTQGVYDK HHHHHHHHHCCHHHH | 30.61 | 25381059 | |
| 200 | Phosphorylation | LNDIHSKTQGVYDKR HHHHHHHHCCHHHHH | 33.30 | 28889911 | |
| 206 | 2-Hydroxyisobutyrylation | KTQGVYDKRQTLFNK HHCCHHHHHHHHHHH | 28.81 | - | |
| 206 | Acetylation | KTQGVYDKRQTLFNK HHCCHHHHHHHHHHH | 28.81 | 24489116 | |
| 240 | Ubiquitination | ADFDNEFKSFRAKLD HHCCHHHHHHHHHHH | 42.37 | 24961812 | |
| 240 | Succinylation | ADFDNEFKSFRAKLD HHCCHHHHHHHHHHH | 42.37 | 23954790 | |
| 240 | Acetylation | ADFDNEFKSFRAKLD HHCCHHHHHHHHHHH | 42.37 | 24489116 | |
| 241 | Phosphorylation | DFDNEFKSFRAKLDK HCCHHHHHHHHHHHH | 25.86 | 27214570 | |
| 245 | Acetylation | EFKSFRAKLDKERLK HHHHHHHHHHHHHHH | 53.62 | 24489116 | |
| 260 | Phosphorylation | REEEQRLSKLLEQKD HHHHHHHHHHHHHCC | 24.36 | 17287358 | |
| 261 | Acetylation | EEEQRLSKLLEQKDV HHHHHHHHHHHHCCC | 62.78 | 24489116 | |
| 266 | 2-Hydroxyisobutyrylation | LSKLLEQKDVDMGKL HHHHHHHCCCCHHHH | 50.79 | - | |
| 266 | Acetylation | LSKLLEQKDVDMGKL HHHHHHHCCCCHHHH | 50.79 | 24489116 | |
| 272 | Ubiquitination | QKDVDMGKLQEKLTH HCCCCHHHHHHHHHH | 40.12 | 22817900 | |
| 272 | Acetylation | QKDVDMGKLQEKLTH HCCCCHHHHHHHHHH | 40.12 | 24489116 | |
| 276 | Ubiquitination | DMGKLQEKLTHAKIP CHHHHHHHHHHCCCC | 45.80 | 23749301 | |
| 281 | Ubiquitination | QEKLTHAKIPAFTYE HHHHHHCCCCCEEEE | 41.43 | 22817900 | |
| 315 | Phosphorylation | KNILPDLSSNALETK CCCCCCCCCCCCCCC | 29.00 | 24909858 | |
| 316 | Phosphorylation | NILPDLSSNALETKP CCCCCCCCCCCCCCC | 33.16 | 24909858 | |
| 321 | Phosphorylation | LSSNALETKPARKVV CCCCCCCCCCCCCEE | 43.08 | 24961812 | |
| 322 | Acetylation | SSNALETKPARKVVA CCCCCCCCCCCCEEC | 27.57 | 24489116 | |
| 322 | Ubiquitination | SSNALETKPARKVVA CCCCCCCCCCCCEEC | 27.57 | 24961812 | |
| 336 | Phosphorylation | ADDLVLVTPKKDDFV CCCEEEECCCCCCCC | 25.81 | 22369663 | |
| 338 | Acetylation | DLVLVTPKKDDFVNV CEEEECCCCCCCCCC | 60.51 | 24489116 | |
| 339 | Acetylation | LVLVTPKKDDFVNVA EEEECCCCCCCCCCC | 64.83 | 24489116 | |
| 348 | Phosphorylation | DFVNVAPSKSKKYKK CCCCCCCCCCHHHHH | 39.56 | 22369663 | |
| 349 | Acetylation | FVNVAPSKSKKYKKK CCCCCCCCCHHHHHH | 66.30 | 24489116 | |
| 350 | Phosphorylation | VNVAPSKSKKYKKKN CCCCCCCCHHHHHHH | 38.42 | 21440633 | |
| 362 | Phosphorylation | KKNQQKNTENEQPAS HHHCCCCCCCCCCCH | 47.42 | 22369663 | |
| 369 | Phosphorylation | TENEQPASIFNKVDG CCCCCCCHHHHHCCC | 34.10 | 22369663 | |
| 373 | Acetylation | QPASIFNKVDGKFTL CCCHHHHHCCCCEEC | 30.84 | 24489116 | |
| 373 | Ubiquitination | QPASIFNKVDGKFTL CCCHHHHHCCCCEEC | 30.84 | 23749301 | |
| 410 | Acetylation | KITVEQLKKKHEELL EEEHHHHHHHHHHHH | 60.51 | 22865919 | |
| 419 | Acetylation | KHEELLSKQEEQTKQ HHHHHHHHHHHHHHH | 62.79 | 22865919 | |
| 425 | Ubiquitination | SKQEEQTKQNIESVE HHHHHHHHHHHHHHH | 40.83 | 23749301 | |
| 433 | Acetylation | QNIESVEKEIEKLNL HHHHHHHHHHHHCCC | 62.93 | 24489116 | |
| 437 | Acetylation | SVEKEIEKLNLDYSN HHHHHHHHCCCCCCC | 48.62 | 24489116 | |
| 445 | Acetylation | LNLDYSNKEQQVKKE CCCCCCCHHHHHHHH | 51.46 | 24489116 | |
| 445 | Ubiquitination | LNLDYSNKEQQVKKE CCCCCCCHHHHHHHH | 51.46 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BFR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BFR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BFR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32; SER-315 AND THR-336,AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32 AND THR-336, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-336, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-336, AND MASSSPECTROMETRY. | |
