LIP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIP1_YEAST
• UniProt AC: Q03579
• Protein Name: Ceramide synthase subunit LIP1
• Gene Name: LIP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 150
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Component of the ceramide synthase complex required for synthesis of ceramides..
• Protein Sequence: MSQPTPIITTKSAAKPKPKIFNLFRVCFISLLLIAAVEYFKYGTRINYEWFHCTPIKEPQSGSVIKLWARGGPSCDKRGEYKTIVKRITRDYEPNDEHLSFCIIENDNVPPVHYPIHEDKGEPGYVAYVGYDTDSELVQELCADSTIYHM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQPTPIIT ------CCCCCCEEE	44.88	28152593
5	Phosphorylation	---MSQPTPIITTKS ---CCCCCCEEECCC	21.34	19823750
61	Phosphorylation	TPIKEPQSGSVIKLW EECCCCCCCCEEEEE	43.69	27017623
63	Phosphorylation	IKEPQSGSVIKLWAR CCCCCCCCEEEEEEC	26.39	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAG1_YEAST	LAG1	physical	15692566
LAC1_YEAST	LAC1	physical	15692566
LIP1_YEAST	LIP1	physical	15692566
LAG1_YEAST	LAG1	physical	11283351
LAC1_YEAST	LAC1	physical	11283351
LAG1_YEAST	LAG1	physical	18719252
SEC62_YEAST	SEC62	physical	18719252
ELO3_YEAST	ELO3	genetic	20709688
SUR2_YEAST	SUR2	genetic	22166213
LCB4_YEAST	LCB4	genetic	22166213
LCB2_YEAST	LCB2	genetic	23891562
SPO7_YEAST	SPO7	genetic	23891562
ATC1_YEAST	PMR1	genetic	23891562
GUP1_YEAST	GUP1	genetic	23891562
HAC1_YEAST	HAC1	genetic	23891562
PSD1_YEAST	PSD1	genetic	23891562
VPS1_YEAST	VPS1	genetic	23891562
SRO7_YEAST	SRO7	genetic	23891562
ELO3_YEAST	ELO3	genetic	23891562
SEC7_YEAST	SEC7	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
BIG1_YEAST	BIG1	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
RL8A_YEAST	RPL8A	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
CKS1_YEAST	CKS1	genetic	27708008
KRR1_YEAST	KRR1	genetic	27708008
SCC1_YEAST	MCD1	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
SC61G_YEAST	SSS1	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
PANK_YEAST	CAB1	genetic	27708008
RFC2_YEAST	RFC2	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
ORC4_YEAST	ORC4	genetic	27708008
MED10_YEAST	NUT2	genetic	27708008
DEP1_YEAST	DEP1	genetic	27708008
FAT1_YEAST	FAT1	genetic	27708008
ELO2_YEAST	ELO2	genetic	27708008
TPS2_YEAST	TPS2	genetic	27708008
SGPL_YEAST	DPL1	genetic	27708008
SUR2_YEAST	SUR2	genetic	27708008
LCMT1_YEAST	PPM1	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
ATC1_YEAST	PMR1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
DS1P1_YEAST	LCB3	genetic	27708008
LAC1_YEAST	LAC1	genetic	27708008
NKP2_YEAST	NKP2	genetic	27708008
ELO3_YEAST	ELO3	genetic	27708008
YL407_YEAST	YLR407W	genetic	27708008
SST2_YEAST	SST2	genetic	27708008
SOK2_YEAST	SOK2	genetic	27708008
EOS1_YEAST	EOS1	genetic	27708008
PHO80_YEAST	PHO80	genetic	27708008
CSK22_YEAST	CKA2	genetic	27708008
LEO1_YEAST	LEO1	genetic	27708008
MGR2_YEAST	MGR2	genetic	27708008
ATPN_YEAST	ATP20	genetic	27708008
MED1_YEAST	MED1	genetic	27708008
SUE1_YEAST	SUE1	genetic	27708008
KASH5_HUMAN	CCDC155	physical	27107014
HOG1_YEAST	HOG1	genetic	29215176

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.