SOK2_YEAST - dbPTM
SOK2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOK2_YEAST
UniProt AC P53438
Protein Name Protein SOK2
Gene Name SOK2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 785
Subcellular Localization Nucleus .
Protein Description Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth..
Protein Sequence MPIGNPINTNDIKSNRMRQESNMSAVSNSESTIGQSTQQQQQQQQYLGQSVQPLMPVSYQYVVPEQWPYPQYYQQPQSQSQQQLQSQPQMYQVQESFQSSGSDSNASNPPSTSVGVPSNATATALPNGSAITTKKSNNSTNISNNVPYYYYFPQMQAQQSMAYSYPQAYYYYPANGDGTTNGATPSVTSNQVQNPNLEKTYSTFEQQQQHQQQQQLQAQTYPAQPPKIGNAFSKFSKSGPPSDSSSGSMSPNSNRTSRNSNSISSLAQQPPMSNYPQPSTYQYPGFHKTSSIPNSHSPIPPRSLTTPTQGPTSQNGPLSYNLPQVGLLPPQQQQQVSPLYDGNSITPPVKPSTDQETYLTANRHGVSDQQYDSMAKTMNSFQTTTIRHPMPLIATTNATGSNTSGTSASIIRPRVTTTMWEDEKTLCYQVEANGISVVRRADNDMVNGTKLLNVTKMTRGRRDGILKAEKIRHVVKIGSMHLKGVWIPFERALAIAQREKIADYLYPLFIRDIQSVLKQNNPSNDSSSSSSSTGIKSISPRTYYQPINNYQNPNGPSNISAAQLTYSSMNLNNKIIPNNSIPAVSTIAAGEKPLKKCTMPNSNQLEGHTITNLQTLSATMPMKQQLMGNIASPLSYPRNATMNSASTLGITPADSKPLTPSPTTTNTNQSSESNVGSIHTGITLPRVESESASHSKWSKEADSGNTVPDNQTLKEPRSSQLPISALTSTDTDKIKTSTSDEATQPNEPSEAEPVKESESSKSQVDGAGDVSNEEIAADDTKKQEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
200PhosphorylationQNPNLEKTYSTFEQQ
CCCCHHHHHHHHHHH		17.2127017623
234AcetylationKIGNAFSKFSKSGPP
CCHHHCHHHCCCCCC		47.4024489116
236PhosphorylationGNAFSKFSKSGPPSD
HHHCHHHCCCCCCCC		29.6427017623
238PhosphorylationAFSKFSKSGPPSDSS
HCHHHCCCCCCCCCC		56.1627017623
245PhosphorylationSGPPSDSSSGSMSPN
CCCCCCCCCCCCCCC		43.6521440633
246PhosphorylationGPPSDSSSGSMSPNS
CCCCCCCCCCCCCCC		38.5522890988
248PhosphorylationPSDSSSGSMSPNSNR
CCCCCCCCCCCCCCC		20.3122890988
250PhosphorylationDSSSGSMSPNSNRTS
CCCCCCCCCCCCCCC		23.7221082442
253PhosphorylationSGSMSPNSNRTSRNS
CCCCCCCCCCCCCCC		30.9521440633
260PhosphorylationSNRTSRNSNSISSLA
CCCCCCCCCCHHHHH		30.7419779198
262PhosphorylationRTSRNSNSISSLAQQ
CCCCCCCCHHHHHCC		24.5421440633
265PhosphorylationRNSNSISSLAQQPPM
CCCCCHHHHHCCCCC		26.5019779198
289PhosphorylationQYPGFHKTSSIPNSH
CCCCCCCCCCCCCCC		21.0923749301
290PhosphorylationYPGFHKTSSIPNSHS
CCCCCCCCCCCCCCC		30.9522369663
291PhosphorylationPGFHKTSSIPNSHSP
CCCCCCCCCCCCCCC		47.5022369663
295PhosphorylationKTSSIPNSHSPIPPR
CCCCCCCCCCCCCCC		21.7122369663
297PhosphorylationSSIPNSHSPIPPRSL
CCCCCCCCCCCCCCC		25.0922369663
358PhosphorylationPSTDQETYLTANRHG
CCCCCCCEECCCCCC		10.9927017623
373PhosphorylationVSDQQYDSMAKTMNS
CCHHHHHHHHHHHHH		18.7327017623
380PhosphorylationSMAKTMNSFQTTTIR
HHHHHHHHHHCCCCC		14.1230377154
385PhosphorylationMNSFQTTTIRHPMPL
HHHHHCCCCCCCCEE		21.2830377154
395PhosphorylationHPMPLIATTNATGSN
CCCEEEEEECCCCCC		17.3722890988
396PhosphorylationPMPLIATTNATGSNT
CCEEEEEECCCCCCC		17.5222890988
399PhosphorylationLIATTNATGSNTSGT
EEEEECCCCCCCCCC		43.1222890988
401PhosphorylationATTNATGSNTSGTSA
EEECCCCCCCCCCCC		32.3622890988
403PhosphorylationTNATGSNTSGTSASI
ECCCCCCCCCCCCEE		30.1722890988
404PhosphorylationNATGSNTSGTSASII
CCCCCCCCCCCCEEE		44.3022890988
406PhosphorylationTGSNTSGTSASIIRP
CCCCCCCCCCEEECC		22.3822890988
407PhosphorylationGSNTSGTSASIIRPR
CCCCCCCCCEEECCE		24.4422890988
409PhosphorylationNTSGTSASIIRPRVT
CCCCCCCEEECCEEE		20.5122890988
515PhosphorylationLFIRDIQSVLKQNNP
HHHHHHHHHHHHCCC		29.7430377154
523PhosphorylationVLKQNNPSNDSSSSS
HHHHCCCCCCCCCCC		56.2322369663
526PhosphorylationQNNPSNDSSSSSSST
HCCCCCCCCCCCCCC		36.0522369663
527PhosphorylationNNPSNDSSSSSSSTG
CCCCCCCCCCCCCCC		36.7822369663
528PhosphorylationNPSNDSSSSSSSTGI
CCCCCCCCCCCCCCC		37.8923749301
529PhosphorylationPSNDSSSSSSSTGIK
CCCCCCCCCCCCCCC		35.8722369663
530PhosphorylationSNDSSSSSSSTGIKS
CCCCCCCCCCCCCCC		30.2022369663
531PhosphorylationNDSSSSSSSTGIKSI
CCCCCCCCCCCCCCC		33.5923749301
532PhosphorylationDSSSSSSSTGIKSIS
CCCCCCCCCCCCCCC		32.3822369663
533PhosphorylationSSSSSSSTGIKSISP
CCCCCCCCCCCCCCC		44.8922369663
537PhosphorylationSSSTGIKSISPRTYY
CCCCCCCCCCCCCEE		26.7822369663
539PhosphorylationSTGIKSISPRTYYQP
CCCCCCCCCCCEEEC		18.5420377248
542PhosphorylationIKSISPRTYYQPINN
CCCCCCCCEEECCCC		29.9321440633
543PhosphorylationKSISPRTYYQPINNY
CCCCCCCEEECCCCC		11.0320377248
544PhosphorylationSISPRTYYQPINNYQ
CCCCCCEEECCCCCC		13.7520377248
632PhosphorylationQLMGNIASPLSYPRN
HHHCCCCCCCCCCCC		23.6825752575
661PhosphorylationDSKPLTPSPTTTNTN
CCCCCCCCCCCCCCC		29.6428132839
689PhosphorylationITLPRVESESASHSK
CCCCCCCCCCCCCCC		33.7130377154
696AcetylationSESASHSKWSKEADS
CCCCCCCCCCCCCCC		50.4922865919
699AcetylationASHSKWSKEADSGNT
CCCCCCCCCCCCCCC		56.6724489116
718PhosphorylationQTLKEPRSSQLPISA
CCCCCCCCCCCCCCC		32.9022369663
719PhosphorylationTLKEPRSSQLPISAL
CCCCCCCCCCCCCCC		36.7022369663
731PhosphorylationSALTSTDTDKIKTST
CCCCCCCCCCCCCCC		39.0030377154
733AcetylationLTSTDTDKIKTSTSD
CCCCCCCCCCCCCCC		48.4724489116
743PhosphorylationTSTSDEATQPNEPSE
CCCCCCCCCCCCCCC		42.3823749301
749PhosphorylationATQPNEPSEAEPVKE
CCCCCCCCCCCCCCC		43.1723749301
762PhosphorylationKESESSKSQVDGAGD
CCCCCCCCCCCCCCC		37.0728132839
771PhosphorylationVDGAGDVSNEEIAAD
CCCCCCCCHHHHCCC		43.1722369663
780PhosphorylationEEIAADDTKKQEK--
HHHCCCCCHHHCC--		40.4628132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
719SPhosphorylationKinaseATM/ATR-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOK2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOK2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MSN2_YEASTMSN2physical
11238897
KAPB_YEASTTPK2genetic
8524252
KIP1_YEASTKIP1physical
16554755
CYPD_YEASTCPR5physical
16554755
PRP22_YEASTPRP22physical
16554755
PRS8_YEASTRPT6physical
16554755
ADY1_YEASTPFS1physical
18719252
SOK2_YEASTSOK2physical
19345193
RSF2_YEASTRSF2genetic
21127252
YAK1_YEASTYAK1genetic
21127252
MIG1_YEASTMIG1genetic
21127252
CBF1_YEASTCBF1genetic
21127252
FMP48_YEASTFMP48genetic
21127252
SWI4_YEASTSWI4genetic
21127252
SET1_YEASTSET1genetic
21127252
IXR1_YEASTIXR1genetic
21127252
RAD52_YEASTRAD52genetic
21127252
NRG1_YEASTNRG1genetic
21127252
PTK2_YEASTPTK2genetic
21127252
LCB5_YEASTLCB5genetic
21127252
PHD1_YEASTPHD1genetic
21127252
MBP1_YEASTMBP1genetic
21127252
VIP1_YEASTVIP1genetic
21127252
KAPC_YEASTTPK3genetic
21127252
CHA4_YEASTCHA4genetic
21127252
MDS3_YEASTMDS3genetic
21127252
KNS1_YEASTKNS1genetic
21127252
PPZ1_YEASTPPZ1genetic
21127252
ELM1_YEASTELM1genetic
21127252
MET18_YEASTMET18genetic
21127252
KAPA_YEASTTPK1genetic
21127252
RPI1_YEASTRPI1genetic
21127252
STB5_YEASTSTB5genetic
21127252
KC13_YEASTYCK3genetic
21127252
RTK1_YEASTRTK1genetic
21127252
YOX1_YEASTYOX1genetic
21127252
CG13_YEASTCLN3genetic
21127252
FUS3_YEASTFUS3genetic
21127252
OPI1_YEASTOPI1genetic
21127252
PVH1_YEASTYVH1genetic
21127252
PACC_YEASTRIM101genetic
21127252
VPS71_YEASTVPS71genetic
21127252
SET2_YEASTSET2genetic
21127252
MRC1_YEASTMRC1genetic
21127252
ASH1_YEASTASH1genetic
22984072
TEC1_YEASTTEC1genetic
22984072
PACC_YEASTRIM101genetic
22984072
FLO8_YEASTFLO8genetic
22984072
MFG1_YEASTMFG1genetic
22984072
MSS1_YEASTMSS1genetic
22984072
FLO11_YEASTFLO11genetic
22984072
NHP10_YEASTNHP10genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
FADH_YEASTSFA1genetic
27708008
NRG1_YEASTNRG1genetic
27708008
ARO1_YEASTARO1genetic
27708008
SNX41_YEASTSNX41genetic
27708008
RAD4_YEASTRAD4genetic
27708008
PES4_YEASTPES4genetic
27708008
YBP2_YEASTYBP2genetic
27708008
ACBP_YEASTACB1genetic
27708008
MPC2_YEASTMPC2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
IRC8_YEASTIRC8genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
SIC1_YEASTSIC1genetic
27708008
ARP6_YEASTARP6genetic
27708008
VIP1_YEASTVIP1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
PEX15_YEASTPEX15genetic
27708008
OST3_YEASTOST3genetic
27708008
YO304_YEASTBIL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOK2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-297; SER-632AND SER-771, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-719, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, AND MASSSPECTROMETRY.

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